scholarly journals Catalytic antibodies and enzyme inhibitors

1994 ◽  
Vol 66 (4) ◽  
pp. 703-708 ◽  
Author(s):  
K. D. Janda
Keyword(s):  
Enzyme Inhibitors ◽  
Catalytic Antibodies

scholarly journals Synthetic Methods of Phosphonopeptides

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5894
Author(s):  
Jiaxi Xu
Keyword(s):  
Enzyme Inhibitors ◽  
Condensation Reaction ◽  
Catalytic Antibodies ◽  
Synthetic Methods ◽  
Coupling Reagents ◽  
Efficient Strategy ◽  
Peptide Esters ◽  
Aminoalkylphosphonic Acid

Phosphonopeptides are phosphorus analogues of peptides and have been widely applied as enzyme inhibitors and antigens to induce catalytic antibodies. Phosphonopeptides generally contain one aminoalkylphosphonic acid residue and include phosphonopeptides with C-terminal aminoalkylphosphonic acids and phosphonopeptides with a phosphonamidate bond. The phosphonamidate bond in the phosphonopeptides is generally formed via phosphonylation with phosphonochloridates, condensation with coupling reagents and enzymes, and phosphinylation followed by oxidation. Pseudo four-component condensation reaction of amides, aldehydes, alkyl dichlorophosphites, and amino/peptide esters is an alternative, convergent, and efficient strategy for synthesis of phosphonopeptides through simultaneous construction of aminoalkylphosphonic acids and formation of the phosphonamidate bond. This review focuses on the synthetic methods of phosphonopeptides containing a phosphonamidate bond.

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