Growth Hormone Increases Bone Mineral Content in Postmenopausal Osteoporosis: A Randomized Placebo-Controlled Trial

2003 ◽  
Vol 18 (3) ◽  
pp. 393-405 ◽  
Author(s):  
Kerstin Landin-Wilhelmsen ◽  
Anders Nilsson ◽  
Ingvar Bosaeus ◽  
Bengt-Åke Bengtsson
Keyword(s):  
Growth Hormone ◽  
Bone Mineral Content ◽  
Postmenopausal Osteoporosis ◽  
Bone Mineral ◽  
Mineral Content ◽  
Controlled Trial

Physical Exercise as Prophylaxis against Involutional Vertebral Bone Loss: A Controlled Trial

1983 ◽  
Vol 64 (5) ◽  
pp. 541-546 ◽  
Author(s):  
Bjørn Krølner ◽  
Birte Toft ◽  
Stig Pors Nielsen ◽  
Erik Tøndevold
Keyword(s):  
Lumbar Spine ◽  
Bone Loss ◽  
Physical Exercise ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Controlled Trial ◽  
Exercise Group ◽  
Control Group ◽  
Normal Women

1. The skeletal effects of physical training were studied in a controlled trial involving 31 healthy women (aged 50–73 years) with previous Colles' fracture of the forearm. The bone mineral content of the lumbar spine and both distal forearms was measured by dual-photon (153Gd) absorptiometry. 2. The participants were allocated to either a physical exercise group or a control group. The former group followed a standardized exercise programme, exercising for 1 h twice weekly during 8 months. 3. Twenty-seven women completed the study. Lumbar spine bone mineral content of the exercise group increased by 3.5%, whereas that of the control group decreased by 2.7%. The rate of bone loss in the control group equalled that of age-matched normal women. 4. The changes in forearm bone mineral content appeared to be independent of the exercise. The bone mineral content of the previously fractured forearm remained nearly unchanged. The bone mineral content of the uninjured forearm decreased on average by 3.5%. 5. The data suggest that physical exercise can inhibit or reverse the involutional bone loss from the lumbar vertebrae in normal women. Physical exercise may prevent spinal osteoporosis.

scholarly journals Elevated levels of growth hormone increase bone mineral content in normal young mice, but not in ovariectomized mice.

Endocrinology ◽  
1996 ◽  
Vol 137 (8) ◽  
pp. 3368-3374 ◽  
Author(s):  
J Sandstedt ◽  
J Törnell ◽  
E Norjavaara ◽  
O G Isaksson ◽  
C Ohlsson
Keyword(s):  
Growth Hormone ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Ovariectomized Mice ◽  
Young Mice

Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density

2009 ◽  
Vol 10 (9) ◽  
pp. 1352-1358 ◽  
Author(s):  
Harold N. Rosen ◽  
Vicki Chen ◽  
Antonio Cittadini ◽  
Susan L. Greenspan ◽  
Pamela S. Douglas ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Mineral Density ◽  
Growing Rats ◽  
Igf I

scholarly journals Body Composition Changes Following a Concurrent Exercise Intervention in Perimenopausal Women: The FLAMENCO Project Randomized Controlled Trial

2019 ◽  
Vol 8 (10) ◽  
pp. 1678
Author(s):  
Irene Coll-Risco ◽  
Pedro Acosta-Manzano ◽  
Milkana Borges-Cosic ◽  
Daniel Camiletti-Moiron ◽  
Pilar Aranda ◽  
...  
Keyword(s):  
Body Composition ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Exercise Program ◽  
Exercise Group ◽  
Control Group ◽  
Perimenopausal Women

We assessed the effects of a 16-week primary-care-based exercise program on body composition in perimenopausal women. The women (n = 150) were randomized into control (n = 75) or exercise (n = 75) groups. Exercise was provided in a 16-week (60 min/session, 3 days/week) concurrent program. Body composition was measured using dual-energy X-ray absorptiometry. These are secondary analyses of the FLAMENCO Project (Clinical Trials Reference NCT02358109). In the intention-to-treat analyses, the control group showed no changes in body mass index (BMI) between post- and pre-test, whereas the exercise group showed a 0.75 kg/m2 decrease in BMI (95% CI: −1.29 to −0.22; p = 0.006). Gynoid and android fat mass in control group decreased by 98.3 g and 46.1 g after the 16 weeks, whereas they decreased by 213 g and 139 g in the exercise group, respectively (95% CI: −209 to −3.86; p = 0.042 and 95% CI: −164 to −26.9; p = 0.007, respectively). The control group decreased their pelvis bone mineral content by 2.85 g in the post-test compared with the pre-test, whereas the exercise group increased it by 1.13 g (95% CI: 0.93 to 7.81; p = 0.013). Per-protocol analyses showed similar results. These analyses suggest that the exercise intervention decreased fat depositions and BMI. Exercise might improve bone mineral content in specific areas such as the pelvis.

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