High-Performance Label-Free Biosensing by Long Period Gratings

Author(s):  
F. Baldini ◽  
F. Chiavaioli ◽  
A. Giannetti ◽  
S. Tombelli ◽  
C. Trono
2011 ◽  
Vol 26 (12) ◽  
pp. 4774-4778 ◽  
Author(s):  
Zonghu He ◽  
Fei Tian ◽  
Yinian Zhu ◽  
Nina Lavlinskaia ◽  
Henry Du

2015 ◽  
Vol 23 (7) ◽  
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Mateusz Smietana ◽  
Marcin Koba ◽  
Ewa Brzozowska ◽  
Krzysztof Krogulski ◽  
Jakub Nakonieczny ◽  
...  

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Marcin Koba ◽  
Mateusz Śmietana ◽  
Sabina Górska ◽  
Monika Janik ◽  
...  

2012 ◽  
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pp. 486-491 ◽  
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Annamaria Sandomenico ◽  
Viera Malachovská ◽  
Anna Borriello ◽  
Michele Giordano ◽  
...  

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Umesh Tiwari ◽  
Nilima ◽  
Shivendu Prashar ◽  
Bhargab Das ◽  
...  

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L. Dong ◽  
W.F. Liu ◽  
J.P. de Sandro ◽  
L. Reekie ◽  
...  

Sensors ◽  
2020 ◽  
Vol 20 (13) ◽  
pp. 3772 ◽  
Author(s):  
Tinko Eftimov ◽  
Monika Janik ◽  
Marcin Koba ◽  
Mateusz Śmietana ◽  
Predrag Mikulic ◽  
...  

Selected optical fiber sensors offer extraordinary sensitivity to changes in external refractive (RI), which make them promising for label-free biosensing. In this work the most sensitive ones, namely long-period gratings working at (DTP-LPG) and micro-cavity in-line Mach-Zehnder interferometers (µIMZI) are discussed for application in bacteria sensing. We describe their working principles and RI sensitivity when operating in water environments, which is as high as 20,000 nm/RIU (Refractive index unit) for DTP-LPGs and 27,000 nm/RIU for µIMZIs. Special attention is paid to the methods to enhance the sensitivity by etching and nano-coatings. While the DTP-LPGs offer a greater interaction length and sensitivity to changes taking place at their surface, the µIMZIs are best suited for investigations of sub-nanoliter and picoliter volumes. The capabilities of both the platforms for bacteria sensing are presented and compared for strains of Escherichia coli, lipopolysaccharide E. coli, outer membrane proteins of E. coli, and Staphylococcus aureus. While DTP-LPGs have been more explored for bacteria detection in 102–106 Colony Forming Unit (CFU)/mL for S. aureus and 103–109 CFU/mL for E. coli, the µIMZIs reached 102–108 CFU/mL for E. coli and have a potential for becoming picoliter bacteria sensors.


2003 ◽  
Vol 22 (4) ◽  
pp. 225-237
Author(s):  
K. J. GRANT ◽  
ROBERTS A. ◽  
D. N. JAMIESON ◽  
B. ROUT ◽  
C. CHER

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 1977
Author(s):  
Ricardo Oliveira ◽  
Liliana M. Sousa ◽  
Ana M. Rocha ◽  
Rogério Nogueira ◽  
Lúcia Bilro

In this work, we demonstrate for the first time the capability to inscribe long-period gratings (LPGs) with UV radiation using simple and low cost amplitude masks fabricated with a consumer grade 3D printer. The spectrum obtained for a grating with 690 µm period and 38 mm length presented good quality, showing sharp resonances (i.e., 3 dB bandwidth < 3 nm), low out-of-band loss (~0.2 dB), and dip losses up to 18 dB. Furthermore, the capability to select the resonance wavelength has been demonstrated using different amplitude mask periods. The customization of the masks makes it possible to fabricate gratings with complex structures. Additionally, the simplicity in 3D printing an amplitude mask solves the problem of the lack of amplitude masks on the market and avoids the use of high resolution motorized stages, as is the case of the point-by-point technique. Finally, the 3D printed masks were also used to induce LPGs using the mechanical pressing method. Due to the better resolution of these masks compared to ones described on the state of the art, we were able to induce gratings with higher quality, such as low out-of-band loss (0.6 dB), reduced spectral ripples, and narrow bandwidths (~3 nm).


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