Determination of Depleted Uranium in Urine via Isotope Ratio Measurements Using Large-Bore Direct Injection High Efficiency Nebulizer—Inductively Coupled Plasma Mass Spectrometry

2004 ◽  
Vol 58 (9) ◽  
pp. 1044-1050 ◽  
Author(s):  
Craig S. Westphal ◽  
John A. McLean ◽  
Shelly J. Hakspiel ◽  
William E. Jackson ◽  
David E. McClain ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Isotope Ratio ◽  
High Efficiency ◽  
Direct Injection ◽  
Depleted Uranium ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Isotope Ratio Measurements

Determination of Memory-Prone Elements Using Direct Injection High Efficiency Nebulizer Inductively Coupled Plasma Mass Spectrometry

2002 ◽  
Vol 56 (8) ◽  
pp. 1006-1012 ◽  
Author(s):  
Su-Ann E. O'Brien ◽  
John A. McLean ◽  
Billy W. Acon ◽  
Barbara J. Eshelman ◽  
William F. Bauer ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
High Efficiency ◽  
Direct Injection ◽  
Dead Volume ◽  
Spray Chamber ◽  
Inductively Coupled ◽  
Freeze Dried ◽  
Plasma Mass Spectrometry

A direct injection high efficiency nebulizer (DIHEN) and a large-bore DIHEN (LB-DIHEN) are investigated for the determination of difficult-to-analyze and memory-prone elements (mercury, iodine, and boron). The determination of such elements is problematic using conventional sample introduction systems incorporating spray chambers and/or desolvation devices owing to their large surface area and hence long wash-out characteristics. With the DIHEN or LB-DIHEN, the spray chamber is eliminated and the dead volume is reduced to <10 μL, thus reducing memory effects. In comparison with the crossflow-spray chamber combination, wash-in and wash-out times are reduced to less than 10 s when a DIHEN or LB-DIHEN is used for mercury, iodine, and boron at a concentration of 100 ng/mL. The accuracy of the DIHEN-ICPMS (inductively coupled plasma mass spectrometry) technique is evaluated in the analysis of the National Institute of Standards and Technology standard reference material (NIST SRM) 2670 (Toxic Metals in Freeze-Dried Urine) and NIST SRM 8414 (Bovine Muscle Powder). Further, the effectiveness of the DIHEN-ICPMS technique is examined in the determination of mercury and iodine in an alternative remedy medicine (seahorse genital tonic pills) and boron in rodent liver samples as part of a pharmacokinetic screening study for boron neutron capture therapy.

scholarly journals tudy on the determination of ¹⁰B/¹¹B isotope ratio in water samples by isotope dilution – inductively coupled plasma mass spectrometry (ID-ICPMS)

2021 ◽  
Vol 7 (3) ◽  
pp. 8-16
Author(s):  
Kim Dung Nguyen Thi ◽  
Thi Lien Nguyen
Keyword(s):  
Mass Spectrometry ◽  
Isotope Dilution ◽  
Water Samples ◽  
Inductively Coupled Plasma ◽  
Isotope Ratio ◽  
Isotopic Ratio ◽  
Primary Coolant ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

The determination of 10B/11B isotope ratio and boron concentration in various watersamples using isotope dilution technique with inductively coupled plasma mass spectrometry (ICPMS) was studied. The interferences on precision and accuracy in isotopic ratio determination by ICPMS such as memory effects, dead time, spectral overlap of 12C were investigated for the selection of optimum conditions. By the addition of certain amounts of enriched 10B into samples, the 10B/11B ratio was determined through ICP-MS signal of 10B and 11B. The detection limit for 10B and 11B was experimentally obtained as 0.26 µg/L and 0.92 µg/L, respectively. The ratios of 10B/11B in measured water samples varied in the ranged between 0.1905 and 0.2484 for different matrices. This method has been then applied for the determination of boron isotopic ratio in VVER-1000 reactor-type simulated primary coolant water and in some environmental water samples.

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