scholarly journals Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, placebo-controlled trial

PLoS Medicine ◽  
2017 ◽  
Vol 14 (9) ◽  
pp. e1002390 ◽  
Author(s):  
Caroline A. Crowther ◽  
Pat Ashwood ◽  
Andrew J. McPhee ◽  
Vicki Flenady ◽  
Thach Tran ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Pregnant Women ◽  
Distress Syndrome ◽  
Controlled Trial ◽  
Neonatal Respiratory Distress Syndrome ◽  
Vaginal Progesterone ◽  
Neonatal Respiratory Distress

Novel Adjuvant Therapy with Zinc Supplementation in Neonatal Respiratory Distress Syndrome

2021 ◽  
Vol 21 ◽  
Author(s):  
Mohamed Shawky Elfarargy ◽  
Ghada M Al-Ashmawy ◽  
Sally Abu-Risha ◽  
Haidy Khattab
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Controlled Trial ◽  
Neonatal Respiratory Distress Syndrome ◽  
Prospective Randomized Controlled Trial ◽  
Neonatal Respiratory Distress ◽  
Duration Of Hospitalization ◽  
Group 2 ◽  
Group 1

Background: Neonatal respiratory distress syndrome (RDS) is a common dangerous chest problem that is caused by a lack of surfactant. Aim: The aim of this study was to show the role of zinc as an adjuvant anti-inflammatory therapy in neonatal RDS. Methods: A prospective randomized controlled trial (RCT) study was done on 90 neonates suffering from respiratory distress (RD) who had been diagnosed as RDS. The included neonates were classified into two groups: group 1, which received Zinc (Zn) supplementation, and group 2, which received a placebo. Down score, grades of RDS Malondialdehyde (MDA), Superoxide Dismutase (SOD) andInterleukin-8 (IL-8) were estimated on the 1st and 5th day in the presence of incubators. Results: There were statistically significant differences (SSD) in grades of RDS, Down score, MDA, SOD and IL-8 on the 5th day between group 1 and 2(p = 0.001), and between 1st and 5th day in group 1 (p = 0.001) in the presence of an incubator. There was an SSD between groups 1 and 2 in the duration of hospitalization (p = 0.001) and the number of cases that needed mechanical ventilation (MV) (p = 0.049). Conclusion: Zn supplementation is associated with clinical and laboratory improvement in cases of neonatal RDS. Recommendation: Zn supplementation for RDS neonates.

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