scholarly journals Altered Markers of Brain Development in Crohn’s Disease with Extraintestinal Manifestations – A Pilot Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163202 ◽  
Author(s):  
Anne K. Thomann ◽  
Philipp A. Thomann ◽  
Robert C. Wolf ◽  
Dusan Hirjak ◽  
Christian Schmahl ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Pilot Study ◽  
Crohn's Disease ◽  
Brain Development ◽  
Extraintestinal Manifestations

scholarly journals Creatine Supplementation for Patients with Inflammatory Bowl Diseases: A Scientific Rationale for a Clinical Trial

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1429
Author(s):  
Theo Wallimann ◽  
Caroline H. T. Hall ◽  
Sean P. Colgan ◽  
Louise E. Glover
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Trial ◽  
Crohn’S Disease ◽  
Pilot Study ◽  
Crohn's Disease ◽  
Single Case ◽  
Initial Period ◽  
Creatine Supplementation

Based on theoretical considerations, experimental data with cells in vitro, animal studies in vivo, as well as a single case pilot study with one colitis patient, a consolidated hypothesis can be put forward, stating that “oral supplementation with creatine monohydrate (Cr), a pleiotropic cellular energy precursor, is likely to be effective in inducing a favorable response and/or remission in patients with inflammatory bowel diseases (IBD), like ulcerative colitis and/or Crohn’s disease”. A current pilot clinical trial that incorporates the use of oral Cr at a dose of 2 × 7 g per day, over an initial period of 2 months in conjunction with ongoing therapies (NCT02463305) will be informative for the proposed larger, more long-term Cr supplementation study of 2 × 3–5 g of Cr per day for a time of 3–6 months. This strategy should be insightful to the potential for Cr in reducing or alleviating the symptoms of IBD. Supplementation with chemically pure Cr, a natural nutritional supplement, is well tolerated not only by healthy subjects, but also by patients with diverse neuromuscular diseases. If the outcome of such a clinical pilot study with Cr as monotherapy or in conjunction with metformin were positive, oral Cr supplementation could then be used in the future as potentially useful adjuvant therapeutic intervention for patients with IBD, preferably together with standard medication used for treating patients with chronic ulcerative colitis and/or Crohn’s disease.

scholarly journals DOP019 Effect of vedolizumab treatment on extraintestinal manifestations in patients with Crohn’s disease: a GEMINI 2 post hoc analysis

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S36-S38
Author(s):  
B.G. Feagan ◽  
W.J. Sandborn ◽  
J.-F. Colombel ◽  
S. O’Byrne ◽  
J.M. Khalid ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Extraintestinal Manifestations ◽  
Post Hoc Analysis ◽  
Post Hoc

Extraintestinal Manifestations of Crohn’s Disease

Digestion ◽  
2007 ◽  
Vol 76 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Pascal Juillerat ◽  
Christian Mottet ◽  
Valérie Pittet ◽  
Florian Froehlich ◽  
Christian Felley ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Extraintestinal Manifestations

scholarly journals Vascular anomalies in the mesenteric circulation of patients with Crohn’s disease: a pilot study

2017 ◽  
Vol 6 (2) ◽  
Author(s):  
Matilde Zamboni ◽  
Maria Grazia Sibilla ◽  
Roberto Galeotti ◽  
Massimo Pedriali ◽  
Simona Ascanelli
Keyword(s):  
Crohn’S Disease ◽  
Pilot Study ◽  
Crohn's Disease ◽  
Vascular System ◽  
Current Treatment ◽  
Small Sample ◽  
Vascular Anomalies ◽  
Chronic Inflammatory Bowel Disease ◽  
Mesenteric Circulation ◽  
Inflammatory Bowel

Crohn’s disease (CD) is a chronic inflammatory bowel disease and its pathogenesis is still not well understood. Previous studies suggested the possibility of the involvement of vascular system, but, todate, the mesenteric circulation has poor been investigated, especially in complicated CD cases requiring colectomy. We investigated the mesenteric circulation in a case-control pilot study, including 19 controls and 7 patients affected by complicated cases of CD. Cases and controls underwent selective angiography of both superior and inferior mesenteric district. Transit time was found either significantly shortened in 2/7 cases (29%), or prolonged 5/7 (71%) (P=0.0034 in the superior mesenteric district; P=0.0079 in the inferior mesenteric district), respectively due to the presence of A-V malformations and of a miscellaneous of venous abnormalities, which included thrombosis, hypoplasia and extra-truncular venous malformations. Our study demonstrates the presence of congenital or acquired vascular anomalies in a small sample of CD patients not responder to current treatment and with severe complications. The present pilot study warrants further investigations.

scholarly journals Extraintestinal manifestations of Crohn’s disease

2016 ◽  
Vol 3 ◽  
pp. 218-221
Author(s):  
Bartosz Wójcik ◽  
Karolina Loga ◽  
Marcin Włodarczyk ◽  
Aleksandra Sobolewska-Włodarczyk ◽  
Milena Padysz ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Extraintestinal Manifestations

Effect of natural polyphenols (Pycnogenol) on oxidative stress markers in children suffering from Crohn's disease – a pilot study

2013 ◽  
Vol 47 (8) ◽  
pp. 624-634 ◽  
Author(s):  
M. Koláček ◽  
J. Muchová ◽  
M. Dvořáková ◽  
Z. Paduchová ◽  
I. Žitňanová ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Crohn’S Disease ◽  
Pilot Study ◽  
Crohn's Disease ◽  
Oxidative Stress Markers ◽  
Natural Polyphenols ◽  
Stress Markers

scholarly journals Keep an Eye Out for Crohn’s Disease: Orbital Myositis as the Initial Sign before Gastrointestinal Manifestations

2020 ◽  
Author(s):  
Gilles Jadd Hoilat ◽  
Abinash Subedi ◽  
Mohamad Fekredeen Ayas ◽  
Nuri Ozden
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Pseudotumor Cerebri ◽  
Extraintestinal Manifestations ◽  
Gastrointestinal Manifestations ◽  
Orbital Myositis ◽  
Ocular Manifestations ◽  
Initial Sign ◽  
Intestinal Symptoms ◽  
Work Up

Extraintestinal manifestations of Crohn's disease sometimes occur and can present prior to intestinal symptoms. Ocular manifestations of Crohn's disease are considered rare, with orbital myositis an even rarer manifestation with only a handful of cases reported in the literature. We present the case of a young woman who was diagnosed with orbital myositis, which was initially attributed to pseudotumor cerebri after an extensive negative work-up. Months later, the patient presented with haematochezia, and was subsequently diagnosed with Crohn's disease.

Sa1922 Pilot Study on the Safety and Efficacy of Faecal Microbiota Transplantation in Refractory Crohn's Disease

2012 ◽  
Vol 142 (5) ◽  
pp. S-360 ◽  
Author(s):  
Severine Vermeire ◽  
Marie Joossens ◽  
Kristin Verbeke ◽  
Falk Hildebrand ◽  
Kathleen Machiels ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Pilot Study ◽  
Crohn's Disease ◽  
Faecal Microbiota ◽  
Safety And Efficacy ◽  
Faecal Microbiota Transplantation

scholarly journals Serum Proteome Profile of Crohn's Disease Patients Treated With Infliximab: A Pilot Study

2011 ◽  
Vol 140 (5) ◽  
pp. S-274-S-275
Author(s):  
Maria Gazouli ◽  
Gerassimos J. Mantzaris ◽  
Konstantinos Papamichael ◽  
Aggeliki Papadopoulou ◽  
Konstantinos Vougas ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Pilot Study ◽  
Crohn's Disease ◽  
Serum Proteome ◽  
Proteome Profile
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