scholarly journals High Prevalence of Obesity, Hypertension, Hyperlipidemia, and Diabetes Mellitus in Japanese Outpatients with Schizophrenia: A Nationwide Survey

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166429 ◽  
Author(s):  
Takuro Sugai ◽  
Yutaro Suzuki ◽  
Manabu Yamazaki ◽  
Kazutaka Shimoda ◽  
Takao Mori ◽  
...  
Author(s):  
Vasudeva Acharya ◽  
Govind Gangadharan

Background: Combination antiretroviral therapy (cART) has improved the quality of life and survival of HIV-infected individuals. However, the long term intake of these drugs is associated with multiple metabolic abnormalities eventually leading to increased risk for cardiovascular morbidity and mortality.Methods: Forty five HIV-infected individuals who are on cART having CD4+ cell count of >200 cells/mm3 for at least 2 years were recruited as cases. Age and gender matched, otherwise healthy individuals were taken as controls. Both cases and controls were compared for the prevalence of obesity, abdominal obesity, hypertension, diabetes mellitus and lipid abnormalities.Results: We found higher prevalence of obesity (33.3% vs 26.7%), abdominal obesity (33.3% vs 17.8%), hypertension (33.3% vs 20%), impaired fasting glucose (IFG) (37.7% vs 8.9%), diabetes mellitus (26.7% vs 24.4%), high total cholesterol (33.3% vs 22.2%) and low HDL cholesterol (60% vs 46.7%) among cases compared to controls. The statistically significant difference was noted only for IFG (cases = 17, 37.7%, controls = 4, 8.9%, p value = 0.002). Low HDL cholesterol was the most common metabolic abnormality found in 27 (60%) cases and 21 (46.7%) controls.Conclusions: HIV-infected individuals receiving long term cART have higher prevalence of obesity, hypertension and dysregulations in glucose and lipid metabolism compared to general population and hence, the diagnosis and management of these abnormalities is very important to prevent cardiovascular morbidity and mortality.


2005 ◽  
Vol 70 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Volkan D. Yumuk ◽  
Husrev Hatemi ◽  
Tunc Tarakci ◽  
Nurettin Uyar ◽  
Nurten Turan ◽  
...  

Author(s):  
Sarah Wild ◽  
Jackie Price

Diabetes mellitus represents a group of metabolic disorders characterized by hyperglycaemia, which may or may not be associated with symptoms. The chronic hyperglycaemia of diabetes results from defects in insulin secretion, insulin action, or both, and is associated with long-term organ damage, particularly in the eyes, kidneys, nerves, heart, and blood vessels. Patients with type 2 diabetes have a higher prevalence of obesity (particularly abdominal obesity), hypertension, and lipid disorders, as well as an increased risk of macrovascular disease in coronary, peripheral, and cerebral arterial circulations, than people without diabetes. Microvascular complications of diabetes include retinopathy, which can lead to loss of vision, nephropathy (leading to renal failure), neuropathy (with an increased risk of foot ulcers, amputations, and foot deformations), and autonomic neuropathy, causing cardiovascular, gastrointestinal, genitourinary, and sexual dysfunction. Diabetes may have a serious emotional and social impact on affected individuals and their families, and has major economic implications for society as a whole in both developed and developing countries.


2004 ◽  
Vol 47 (3) ◽  
pp. 387-390 ◽  
Author(s):  
Gisleine Elisa Cavalcante da Silva ◽  
Roberto Barbosa Bazotte ◽  
Rui Curi ◽  
Maria Angélica Rafaini Covas Pereira da Silva

The aim of this study was to investigate risk factors to coronary heart disease in two countryside villages in the State of Paraná, southern Brazil, typical in terms of the poverty and lack of access to public health care. All population was invited to participate in the study. The 462 volunteers (61.3% female, mean age = 42 years) showed high prevalence of hypercholesterolemia (7.0%), hypertriglyceridemia (19.0%), hyperglycemia (11.0%), hypertension (30.0%) and obesity (16.0%). The majority of the individuals, during the interview did not report the diseases detected by the testes. The results revealed that the high prevalence of hypercholesterolemia, hypertriglyceridemia, obesity, hypertension and diabetes mellitus could be consequence of the delayed detection of these diseases or inadequate treatment after diagnostic.


Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Tetsuya Ohira ◽  
Mitsuaki Hosoya ◽  
Seiji Yasumura ◽  
Hiroaki Sato ◽  
Hitoshi Suzuki ◽  
...  

Background: The Great East Japan Earthquake occurred on 11 March 2011 in Japan. To this day, over 140,000 people have been forced to evacuate their homes due to a nuclear accident, which occurred at the Fukushima Daiichi Nuclear Power Plant. Hypothesis: We assessed the hypothesis that prevalence of obesity, hypertension, dyslipidemia, and diabetes mellitus was increased among evacuees after the disaster, compared with that before the disaster. Methods: A prospective study of Japanese subjects aged 40-90 years was undertaken using data collected from 32,949 participants (14,963 men and 17,986 women) in general health checkups conducted in 12 communities, including the evacuation zone specified by the government, between 2008 and 2010. Height, body weight, blood pressure, and blood test such as glucose, hemoglobin A1c (HbA1c), and lipid panel were examined. Follow-up examination was conducted between 2011 and 2012 (at least of 6-month after the disaster). The participants were divided into two groups: evacuees and non-evacuees. Changes in metabolic profiles among the evacuees and non-evacuees were compared between before and after the disaster. Results: 22,117 participants (10,170 men and 11,947 women, follow-up rate: 67%) received follow-up examination after the disaster, and an average follow up was 1.5-years. Mean levels of body weight were significantly increased in the both evacuee and non-evacuee groups after the disaster, and changes in body weight and body mass index were greater in the evacuee group than those in the non-evacuee group; +1.3kg versus +0.3kg, p<0.001, and +0.60kg/m 2 versus +0.13kg/m 2 , p<0.001. In the evacuee group, prevalence of obesity, hypertension, dyslipidemia, and diabetes mellitus was increased after the disaster. Respective prevalence before and after the disaster were 31.8% and 39.4% for obesity (body mass index>=25.0kg/m 2 ), 54.2% and 60.2% for hypertension, 41.2% and 53.9% for dyslipidemia, and 10.2% and 11.9% for diabetes mellitus, while, in the non-evacuee group, those were 28.3% and 30.3%, 54.7% and 60.0%, 42.6% and 49.4%, and 8.5% and 9.9%. Conclusions: Prevalence of obesity, hypertension, dyslipidemia, and diabetes mellitus may be increased among residents, especially evacuees, in the evacuation zone of Fukushima prefecture after the Great East Japan Earthquake.


2020 ◽  
Vol 19 (3) ◽  
pp. 258-264 ◽  
Author(s):  
Diego García-Compeán ◽  
Jesús Zacarías Villarreal-Pérez ◽  
Manuel Enrique de la O. Cavazos ◽  
Fernando Javier Lavalle-Gonzalez ◽  
Omar David Borjas-Almaguer ◽  
...  

2019 ◽  
Vol 15 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Eric Francelino Andrade ◽  
Víviam de Oliveira Silva ◽  
Débora Ribeiro Orlando ◽  
Luciano José Pereira

Introduction: Diabetes mellitus is a metabolic disease characterized by high glycemic levels for long periods. This disease has a high prevalence in the world population, being currently observed an increase in its incidence. This fact is mainly due to the sedentary lifestyle and hypercaloric diets. Non-pharmacological interventions for glycemic control include exercise, which promotes changes in skeletal muscle and adipocytes. Thus, increased glucose uptake by skeletal muscle and decreased insulin resistance through modulating adipocytes are the main factors that improve glycemic control against diabetes. Conclusion: It was sought to elucidate mechanisms involved in the improvement of glycemic control in diabetics in front of the exercise.


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