scholarly journals Development and characterization of an experimental model of diet-induced metabolic syndrome in rabbit

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0178315 ◽  
Author(s):  
Oscar Julián Arias-Mutis ◽  
Vannina G. Marrachelli ◽  
Amparo Ruiz-Saurí ◽  
Antonio Alberola ◽  
Jose Manuel Morales ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Experimental Model

Use of mesenchymal stem cells in an experimental model of metabolic syndrome complicated with cardiomyopathy

2018 ◽  
Vol 22 (1) ◽  
pp. 207-211
Author(s):  
Nagwa Ahmad ◽  
Esam Abdel Raheem ◽  
Hanan Fouad ◽  
Tahia Saleem
Keyword(s):  
Metabolic Syndrome ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Experimental Model

Characterization of Paeniclostridium sordellii Metalloproteinase-1 in vitro and in an experimental model of infection

Anaerobe ◽  
2021 ◽  
pp. 102468
Author(s):  
John M. French ◽  
Eric R. McIndoo ◽  
Caden M. Schlund ◽  
Kevin P. Field ◽  
Alison R. Wolfe ◽  
...  
Keyword(s):  
Experimental Model

scholarly journals Role of Cox-2 in Vascular Inflammation: An Experimental Model of Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Nicolás F. Renna ◽  
Emiliano R. Diez ◽  
Carina Lembo ◽  
Roberto M. Miatello
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Drinking Water ◽  
Experimental Model ◽  
Vascular Remodeling ◽  
Vascular Inflammation ◽  
Left Ventricular ◽  
Wky Rats ◽  
Cox 2

The objective of this work was to demonstrate the role of COX-2 enzyme at the vascular in experimental model of metabolic syndrome. SHR male WKY rats were employed; they were distributed in 8 groups (n=8each): control (W); W + L: WKY rats receiving 20 mg/kg of lumiracoxib by intraesophageal administration; SHR; SHR + L: SHR + 20 mg/kg of lumiracoxib by intraesophageal administration; Fructose-Fed Rats (FFR): WKY rats receiving 10% (w/v) fructose solution in drinking water during all 12 weeks; FFR + L: FFR + 20 mg/kg of lumiracoxib by intraesophageal administration; Fructose-Fed Hypertensive Rats (FFHR): SHR receiving 10% (w/v) fructose solution in drinking water during all 12 weeks; and FFHR + L: FFHR + 20 mg/kg of lumiracoxib by intraesophageal administration. Metabolic variables, blood pressure, morphometric variables, and oxidative stress variables were evaluated; also MMP-2 and MMP-9 (collagenases), VCAM-1, and NF-κB by Westernblot or IFI were evaluated. FFHR presented all variables of metabolic syndrome; there was also an increase in oxidative stress variables; vascular remodeling and left ventricular hypertrophy were evidenced along with a significant increase in the expression of the mentioned proinflammatory molecules and increased activity and expression of collagenase. Lumiracoxib was able to reverse vascular remodeling changes and inflammation, demonstrating the involvement of COX-2 in the pathophysiology of vascular remodeling in this experimental model.

scholarly journals Phenomenological Characterization of Low-Potency Homeopathic Preparations by Means of Pattern Formation in Evaporating Droplets

Homeopathy ◽  
2019 ◽  
Vol 108 (02) ◽  
pp. 108-120 ◽  
Author(s):  
Maria Kokornaczyk ◽  
Sandra Würtenberger ◽  
Stephan Baumgartner
Keyword(s):  
Image Analysis ◽  
Pattern Formation ◽  
Experimental Model ◽  
Animal Origin ◽  
Diffusion Limited Aggregation ◽  
Model Stability ◽  
Promising Tool ◽  
Screening Experiments ◽  
Qualitative Phenomenological

Background Evaporation-induced pattern formation in droplets has been applied to test effects of high potencies. Here we propose for the first time the droplet evaporation method (DEM) as a tool to characterize low potencies on a qualitative and quantitative basis. Materials and Methods The present investigation consisted of: (1) screening of 18 different substances of mineral, vegetal, and animal origin in the 1x to 6x potency range; choice of four substances with characteristic pattern-forming properties; (2) replication experiments aiming at the differentiation of four homeopathic preparations at the same potency levels (2x–6x); and (3) control experiments performed on three preparations. The DEM experimental protocol consisted of the evaporation of droplets of the analyzed potency per se, placed on microscope slides and in controlled conditions. The resulting patterns were photographed and subjected to computerized image analysis. Results The screening experiments yielded a wide variety of patterns. Homeopathic preparations of mineral origin showed the largest variety of forms, whereas potencies of vegetal origin mostly created dendritic patterns, probably due to diffusion-limited aggregation. The here-analyzed image analysis variables (gray-level distribution, entropy, and inverse difference moment) allowed a highly significant differentiation of patterns prepared from four substances (Echinacea, Baptisia, Luffa, and Spongia) at the same potency levels in the range 2x to 4x, whereas patterns obtained from potencies 5x and 6x could no longer be differentiated and resembled the pattern of pure solute (purified water). The control experiments showed reasonable experimental model stability. Conclusions DEM seems to be a promising tool for qualitative phenomenological characterization of homeopathic preparations in low potency. We propose the application of the current experimental model for investigating further research topics in this field, such as the comparison of potencies versus simple dilutions or the contribution of component remedies to the patterns formed by homeopathic combination medicines.

Characterization of gut microbiota composition in HIV-infected patients with metabolic syndrome

2019 ◽  
Vol 75 (3) ◽  
pp. 299-309 ◽  
Author(s):  
María Jesús Villanueva-Millán ◽  
Patricia Pérez-Matute ◽  
Emma Recio-Fernández ◽  
José-Miguel Lezana Rosales ◽  
José-Antonio Oteo
Keyword(s):  
Metabolic Syndrome ◽  
Gut Microbiota ◽  
Microbiota Composition ◽  
Gut Microbiota Composition
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