scholarly journals Global gene expression analysis of the response of physic nut (Jatropha curcas L.) to medium- and long-term nitrogen deficiency

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182700 ◽  
Author(s):  
Qi Kuang ◽  
Sheng Zhang ◽  
Pingzhi Wu ◽  
Yaping Chen ◽  
Meiru Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Analysis ◽  
Jatropha Curcas ◽  
Gene Expression Analysis ◽  
Nitrogen Deficiency ◽  
Global Gene Expression ◽  
Physic Nut ◽  
Jatropha Curcas L ◽  
Global Gene Expression Analysis

scholarly journals Global Gene Expression Analysis of Long-Term Stationary Phase Effects in E. coli K12 MG1655

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96701 ◽  
Author(s):  
Kotakonda Arunasri ◽  
Mohammed Adil ◽  
Pathan Akbar Ali Khan ◽  
Sisinthy Shivaji
Keyword(s):  
Gene Expression ◽  
Stationary Phase ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Global Gene Expression ◽  
E Coli ◽  
Global Gene Expression Analysis

scholarly journals Global Gene Expression Analysis of the Brainstem in EV71- and CVA16-Infected Gerbils

Viruses ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 46 ◽  
Author(s):  
Yi-Sheng Sun ◽  
Zhang-Nv Yang ◽  
Fang Xu ◽  
Chen Chen ◽  
Hang-Jing Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Global Gene Expression ◽  
Solid Foundation ◽  
Differential Gene ◽  
Global Gene Expression Analysis ◽  
Upregulated Genes

Enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) are the two most important pathogens of hand, foot, and mouth disease (HFMD). However, the neuropathogenesis of EV71 and CVA16 has not been elucidated. In our previous study, we established gerbils as a useful model for both EV71 and CVA16 infection. In this work, we used RNA-seq technology to analyze the global gene expression of the brainstem of EV71- and CVA16-infected gerbils. We found that 3434 genes were upregulated while 916 genes were downregulated in EV71-infected gerbils. In CVA16-infected gerbils, 1039 genes were upregulated, and 299 genes were downregulated. We also found significant dysregulation of cytokines, such as IP-10 and CXCL9, in the brainstem of gerbils. The expression levels of 10 of the most upregulated genes were confirmed by real-time RT-PCR, and the upregulated tendency of most genes was in accordance with the differential gene expression (DGE) results. Our work provided global gene expression analysis of virus-infected gerbils and laid a solid foundation for elucidating the neuropathogenesis mechanisms of EV71 and CVA16.

Global Gene Expression Analysis of Long and Short Day 15 Bovine Conceptuses Produced In Vivo.

2012 ◽  
Vol 87 (Suppl_1) ◽  
pp. 192-192
Author(s):  
Callie V. Barnwell ◽  
Christopher M. Ashwell ◽  
Peter W. Farin ◽  
William T. Farmer ◽  
Charlotte E. Farin
Keyword(s):  
Gene Expression ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Global Gene Expression ◽  
Short Day ◽  
Global Gene Expression Analysis

scholarly journals Molecular Pathological Differences in Global Gene Expression between Two Sustained Proliferative Lesions, Nodular Regenerative Hepatocellular Hyperplasia and Hepatocellular Adenoma, in Mice

2018 ◽  
Vol 47 (1) ◽  
pp. 44-52
Author(s):  
Shinji Takasu ◽  
Yuh Yokoo ◽  
Yuji Ishii ◽  
Aki Kijima ◽  
Kumiko Ogawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Messenger Rna ◽  
Gene Expression Analysis ◽  
Hepatocellular Adenoma ◽  
Hierarchical Cluster ◽  
Global Gene Expression ◽  
Molecular Characteristics ◽  
Cytochrome P450 Enzymes ◽  
Global Gene Expression Analysis

Long-term exposure to piperonyl butoxide (PBO) induces multiple nodular masses along with hepatocellular tumors in the liver of mice. The histopathological features of the nodules led to our diagnosis of nodular regenerative hepatocellular hyperplasia (NRH). However, because of the lack of data on the biological characteristics of NRH, whether this lesion is truly nonneoplastic remains unknown. In this study, the molecular characteristics of NRH were compared with those of hepatocellular adenoma (HCA) by global gene expression analysis. Six-week-old male ICR mice were fed a diet containing 6,000 ppm PBO for 43 weeks to induce NRH and HCA development. Complementary DNA microarray analysis was performed using messenger RNA extracted from NRH and HCA frozen sections collected by laser microdissection. Hierarchical cluster analysis showed that all NRH samples clustered together but were separate from the HCA cluster. Pathway analysis revealed activation of the cell cycle and Delta–Notch signaling in both lesions, but the latter was more upregulated in HCA. Downregulation of cytochrome p450 enzymes was observed in NRH, but not in HCA. These results imply that NRH differs from HCA in terms of not only morphological but also molecular characteristics.

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