scholarly journals Survival in untreated hepatocellular carcinoma: A national cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246143
Author(s):  
Young Ae Kim ◽  
Danbee Kang ◽  
Hyeyoung Moon ◽  
Donghyun Sinn ◽  
Minwoong Kang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cohort Study ◽  
Liver Disease ◽  
Treatment Group ◽  
Specific Treatment ◽  
Newly Diagnosed ◽  
Severe Liver ◽  
Risk Of Mortality ◽  
National Cohort ◽  
Severe Liver Disease

This study aimed to analyze the proportion, characteristics and prognosis of untreated hepatocellular carcinoma (HCC) patients in a large representative nationwide study. A cohort study was conducted using the National Health Insurance Service (NHIS) database in Korea. A total of 63,668 newly-diagnosed HCC patients between January 2008 and December 2013 were analyzed. Patients were categorized into treatment group and no treatment group using claim codes after HCC diagnosis. The proportion of untreated HCC patients was 27.6%, decreasing from 33.4% in 2008 to 24.8% in 2013. Compared to treated patients, untreated patients were more likely to be older (P < 0.001), female (P < 0.01), to have a distant SEER stage (P < 0.001), severe liver disease (P < 0.001), and lower income (P < 0.001). The fully-adjusted hazard ratio for all-cause mortality comparing untreated to treated patients was 3.11 (95% CI, 3.04–3.18). The risk of mortality was higher for untreated patients in all pre-defined subgroups, including those with distant SEER stage and those with severe liver disease. About one fourth of newly diagnosed HCC patients did not receive any HCC-specific treatment. Untreated patients showed higher risk of mortality compared to treated patients in all subgroups. Further studies are needed to identify obstacles for HCC treatment and to improve treatment rates.

Repeated measures of FIB-4 improve prediction of severe liver disease: population-based cohort study of 40,729 individuals

2020 ◽  
Vol 73 ◽  
pp. S70-S71
Author(s):  
Hannes Hagström ◽  
Mats Talbäck ◽  
Anna Andreasson ◽  
Göran Walldius ◽  
Niklas Hammar
Keyword(s):  
Cohort Study ◽  
Liver Disease ◽  
Repeated Measures ◽  
Population Based ◽  
Severe Liver ◽  
Severe Liver Disease

Risk factors for development of severe liver disease in more than 400 000 patients with type 2 diabetes: A population-based cohort study

2018 ◽  
Vol 68 ◽  
pp. S823
Author(s):  
K. Björkström ◽  
S. Franzén ◽  
B. Eliasson ◽  
M. Miftaraj ◽  
S. Gudbjornsdottir ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cohort Study ◽  
Liver Disease ◽  
Population Based ◽  
Severe Liver ◽  
Severe Liver Disease

scholarly journals Increased Mortality Among Persons With Chronic Hepatitis C With Moderate or Severe Liver Disease: A Cohort Study

2017 ◽  
Vol 65 (2) ◽  
pp. 235-243 ◽  
Author(s):  
Javier A. Cepeda ◽  
David L. Thomas ◽  
Jacquie Astemborski ◽  
Mark S. Sulkowski ◽  
Gregory D. Kirk ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Cohort Study ◽  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Severe Liver ◽  
Severe Liver Disease

High BMI in late adolescence predicts future severe liver disease and hepatocellular carcinoma: a national, population-based cohort study in 1.2 million men

Gut ◽  
2017 ◽  
Vol 67 (8) ◽  
pp. 1536-1542 ◽  
Author(s):  
Hannes Hagström ◽  
Per Tynelius ◽  
Finn Rasmussen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Cox Regression ◽  
Population Based ◽  
Late Adolescent ◽  
Severe Liver ◽  
Increased Risk ◽  
Severe Liver Disease ◽  
High Bmi

ObjectiveA high body mass index (BMI) is associated with an increased risk for severe liver disease. It is unclear if this risk differs across BMI categories, and if the association is partially attributed to development of type 2 diabetes mellitus (T2DM).DesignWe used register data from more than 1.2 million Swedish men enlisted for conscription between 1969 and 1996. Data regarding new events of severe liver disease and T2DM during follow-up were obtained by record-linkage of population-based registers. We used Cox regression to estimate adjusted HRs for future inpatient care and mortality in severe liver disease and incidence of hepatocellular carcinoma (HCC) across BMI categories, using BMI of 18.5–22.5 kg/m2 as reference.ResultsDuring a follow-up of more than 34 million person-years, 5281 cases of severe liver disease including 251 cases of HCC were identified. An association with severe liver disease was found for overweight (HR 1.49, 95% CI 1.35 to 1.64) and for obese men (HR 2.17, 95% CI 1.82 to 2.59). Development of T2DM further increased the risk for severe liver disease across all BMI categories, for instance, men with obesity and T2DM had a higher risk of severe liver disease (HR 3.28, 95% CI 2.27 to 4.74) than men with obesity free of T2DM (HR 1.72, 95% CI 1.72 to 2.54).ConclusionsA high BMI in late adolescent men was associated with an increased risk of future severe liver disease, including HCC. Development of T2DM during follow-up was associated with a further increased risk of severe liver disease, independent of baseline BMI.

Sign in / Sign up

Export Citation Format

Share Document