scholarly journals Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0253902
Author(s):  
Ghazaleh Ghamkharinejad ◽  
Seyed Hossein Marashi ◽  
Forough Foolad ◽  
Mohammad Javan ◽  
Yaghoub Fathollahi
Keyword(s):  
Valproic Acid ◽  
Protein Level ◽  
Short Term Memory ◽  
Morphine Tolerance ◽  
Short Term ◽  
Acid Pretreatment ◽  
Term Memory ◽  
Gaba A ◽  
Y Maze ◽  
Molecular Aspects

Background ɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure. Objective The effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were investigated. Then hippocampal-dependent tasks named spatial-working and short-term memory procedures using the Y-maze apparatus were examined in morphine tolerant rats. Finally, the changes in the expression of hippocampal GABA-A receptors underlying morphine tolerance were also examined. Methods Rats were treated with daily morphine injections, with or without distinct contextual pairing. To examine the effect of valproic acid on morphine tolerance expression, valproic acid was pretreated an hour before morphine. Spatial-working and short-term memory procedures using the Y-maze apparatus were examined in morphine tolerant rats. Afterwards the changes in the expression of hippocampal GABAα receptors using the quantitative real-time PCR and western blot techniques to detect GABArα subunits mRNAs and protein level were studied. Results Our results showed that both learned and non-associative morphine tolerance influence short-term memory and the subjacent expression of GABArα mRNAs and protein level. Despite its attenuating effects on the development and expression of both learned and non-associative morphine tolerance, only associative morphine tolerance-induced memory dysfunction was ameliorated by valproic acid pretreatment. We also found that the expression of GABArα1, α2, α5 subunits mRNAs and GABAα protein level were affected heavier in associative morphine tolerant rats. Conclusion Our data supports the hypothesis that unconditioned and learned morphine tolerance influences short-term memory and the expression of GABArα 1, α2, α5 mRNAs and GABArα protein level differently, and adds to our understanding of the behavioral and molecular aspects of the learned tolerance to morphine effects.

scholarly journals Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responses

2020 ◽  
Author(s):  
Barbara D. Fontana ◽  
Alistair J. Gibbon ◽  
Madeleine Cleal ◽  
Ari Sudwarts ◽  
David Pritchett ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Life Stress ◽  
Early Life ◽  
Short Term Memory ◽  
Early Life Stress ◽  
Adult Zebrafish ◽  
Short Term ◽  
Term Memory ◽  
Y Maze ◽  
The Impact

AbstractEarly-life stress (ELS) is defined as a short or chronic period of trauma, environmental or social deprivation, which can affect different neurochemical and behavioral patterns during adulthood. Zebrafish (Danio rerio) have been widely used as a model system to understand human neurodevelopmental disorders and display translationally relevant behavioral and stress-regulating systems. In this study, we aimed to investigate the effects of moderate ELS by exposing young animals (six weeks post-fertilization), for three consecutive days, to three stressors, and analyzing the impact of this on adult zebrafish behavior (sixteen weeks post-fertilization). The ELS impact in adults was assessed though analysis of performance on tests of unconditioned memory (free movement pattern Y-maze test), exploratory and anxiety-related task (novel tank diving test) and social cohesion (shoaling test). Here, we show for the first time that moderate ELS increases the number of pure alternations compared to pure repetitions in the unconditioned Y-maze task, suggesting increased spatial short-term memory, but has no effect on shoal cohesion, locomotor profile or anxiety-like behavior. Overall, our data suggest that moderate ELS may be linked to adaptive flexibility which contributes to build ‘resilience’ in adult zebrafish by improving short-term spatial memory performance.

scholarly journals An ensemble code in medial prefrontal cortex links prior events to outcomes during learning

2017 ◽  
Author(s):  
Silvia Maggi ◽  
Adrien Peyrache ◽  
Mark D. Humphries
Keyword(s):  
Prefrontal Cortex ◽  
Short Term Memory ◽  
Decision Rules ◽  
Trial And Error ◽  
Short Term ◽  
Maze Task ◽  
Term Memory ◽  
Neural Ensemble ◽  
Y Maze ◽  
Ensemble Activity

AbstractThe prefrontal cortex is implicated in learning the rules of an environment through trial and error. But it is unclear how such learning is related to the prefrontal cor-tex’s role in short-term memory. Here we asked if the encoding of short-term memory in prefrontal cortex was used by rats learning decision rules in a Y-maze task. We found that a similar pattern of neural ensemble activity was selectively recalled after reinforcement for a correct decision. This reinforcement-selective recall only reliably occurred immediately before the abrupt behavioural transitions indicating successful learning of the current rule, and faded quickly thereafter. We could simultaneously decode multiple, retrospective task events from the ensemble activity, suggesting the recalled ensemble activity had multiplexed encoding of prior events. Our results suggest that successful trial-and-error learning is dependent on reinforcement tagging the relevant features of the environment to maintain in prefrontal cortex short-term memory.

scholarly journals Influence of Antidepressant Medication on Short Term Memory in Chronic Mild Stress Mouse Model of Depression

2021 ◽  
Vol 12 (1) ◽  
pp. 22-28
Author(s):  
Saeed Mustapha ◽  
◽  
Majidat Oshafu ◽  
Umar Adam ◽  
Yusuf Yusha’u ◽  
...  
Keyword(s):  
Mouse Model ◽  
Short Term Memory ◽  
Antidepressant Medication ◽  
Chronic Mild Stress ◽  
Novel Object Recognition ◽  
Mild Stress ◽  
Short Term ◽  
Term Memory ◽  
Novel Object ◽  
Y Maze

Depression is among the most prevalent diseases worldwide. Researchers have identified a link between depression and different types of memory loss, including short term memory (STM). Also, the memory impairment in depression is a function of severity. This study was conducted to evaluate the effect of antidepressant medication on short term memory in chronic mild stress (CMS) mouse model of depression. A total of eighteen female mice were randomly divided into three groups of six mice each (n=6). Group I served as normal control, group II were exposed to CMS for 14 days, group III were exposed to CMS for 14 days, and thereafter treated with paroxetine at a dose of 20 mg/kg for 14 days. Short term memory was assessed using batteries of cognitive tests including the Y-maze and novel object recognition. Further antidepressant effect was measured using the tail suspension test (TST). The results showed that paroxetine at 20 mg/kg significantly improved the short term memory of the depressed female mice (p<0.05) in the Y-maze and novel object (recognition) tasks after CMS. Therefore, paroxetine might be used to enhance short term memory in depressed individuals, although clinical studies are required to confirm this finding.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Working, Declarative, and Procedural Memory in Children With Developmental Language Disorder

2020 ◽  
Vol 63 (12) ◽  
pp. 4162-4178
Author(s):  
Emily Jackson ◽  
Suze Leitão ◽  
Mary Claessen ◽  
Mark Boyes
Keyword(s):  
Working Memory ◽  
Short Term Memory ◽  
Language Disorder ◽  
Declarative Memory ◽  
Memory Systems ◽  
Procedural Memory ◽  
Typically Developing ◽  
Short Term ◽  
Term Memory ◽  
Visual Spatial

Purpose Previous research into the working, declarative, and procedural memory systems in children with developmental language disorder (DLD) has yielded inconsistent results. The purpose of this research was to profile these memory systems in children with DLD and their typically developing peers. Method One hundred four 5- to 8-year-old children participated in the study. Fifty had DLD, and 54 were typically developing. Aspects of the working memory system (verbal short-term memory, verbal working memory, and visual–spatial short-term memory) were assessed using a nonword repetition test and subtests from the Working Memory Test Battery for Children. Verbal and visual–spatial declarative memory were measured using the Children's Memory Scale, and an audiovisual serial reaction time task was used to evaluate procedural memory. Results The children with DLD demonstrated significant impairments in verbal short-term and working memory, visual–spatial short-term memory, verbal declarative memory, and procedural memory. However, verbal declarative memory and procedural memory were no longer impaired after controlling for working memory and nonverbal IQ. Declarative memory for visual–spatial information was unimpaired. Conclusions These findings indicate that children with DLD have deficits in the working memory system. While verbal declarative memory and procedural memory also appear to be impaired, these deficits could largely be accounted for by working memory skills. The results have implications for our understanding of the cognitive processes underlying language impairment in the DLD population; however, further investigation of the relationships between the memory systems is required using tasks that measure learning over long-term intervals. Supplemental Material https://doi.org/10.23641/asha.13250180

Comparison of Auditory, Language, Memory, and Attention Abilities in Children With and Without Listening Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield
Keyword(s):  
Auditory Processing ◽  
Short Term Memory ◽  
Group Differences ◽  
Long Term Memory ◽  
Short Term ◽  
Significant Group ◽  
Term Memory ◽  
Memory And Attention ◽  
Speed And Accuracy

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607

The Link Between Verbal Short-Term Memory and Anomia Treatment Gains

2019 ◽  
Vol 28 (3) ◽  
pp. 1039-1052
Author(s):  
Reva M. Zimmerman ◽  
JoAnn P. Silkes ◽  
Diane L. Kendall ◽  
Irene Minkina
Keyword(s):  
Short Term Memory ◽  
Controlled Trial ◽  
Treatment Success ◽  
Linear Regression Models ◽  
Language Performance ◽  
Short Term ◽  
Term Memory ◽  
Treatment Gains ◽  
Post Hoc

Purpose A significant relationship between verbal short-term memory (STM) and language performance in people with aphasia has been found across studies. However, very few studies have examined the predictive value of verbal STM in treatment outcomes. This study aims to determine if verbal STM can be used as a predictor of treatment success. Method Retrospective data from 25 people with aphasia in a larger randomized controlled trial of phonomotor treatment were analyzed. Digit and word spans from immediately pretreatment were run in multiple linear regression models to determine whether they predict magnitude of change from pre- to posttreatment and follow-up naming accuracy. Pretreatment, immediately posttreatment, and 3 months posttreatment digit and word span scores were compared to determine if they changed following a novel treatment approach. Results Verbal STM, as measured by digit and word spans, did not predict magnitude of change in naming accuracy from pre- to posttreatment nor from pretreatment to 3 months posttreatment. Furthermore, digit and word spans did not change from pre- to posttreatment or from pretreatment to 3 months posttreatment in the overall analysis. A post hoc analysis revealed that only the less impaired group showed significant changes in word span scores from pretreatment to 3 months posttreatment. Discussion The results suggest that digit and word spans do not predict treatment gains. In a less severe subsample of participants, digit and word span scores can change following phonomotor treatment; however, the overall results suggest that span scores may not change significantly. The implications of these findings are discussed within the broader purview of theoretical and empirical associations between aphasic language and verbal STM processing.

Symptomvalidierungstests in der neuropsychologischen Diagnostik: eine Analogstudie

2004 ◽  
Vol 15 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Thomas Merten ◽  
Matthias Henry ◽  
Robin Hilsabeck
Keyword(s):  
Short Term Memory ◽  
Memory Test ◽  
Short Term ◽  
Term Memory ◽  
Word Memory Test ◽  
Word Memory ◽  
Complex Figure ◽  
Trail Making ◽  
Figure Test ◽  
Word Completion

Zusammenfassung: In der neuropsychologischen Diagnostik, mehr noch aber in der Begutachtung gewinnen Symptomvalidierungstests (SVT) zur Untersuchung der Leistungsmotivation zunehmend an Bedeutung. In einer Analogstudie wurde die Güte zweier international bekannter Verfahren (Word Memory Test; Amsterdam Short Term Memory Test) sowie einer Neuentwicklung (Word Completion Memory Test) untersucht. Zusätzlich wurden Leistungstests eingesetzt: der Trail Making Test (TMT), der Complex Figure Test sowie die Standard Progressive Matrices (SPM). Eine Gruppe von 10 experimentellen Simulanten wurde spezifisch auf die Vortäuschung von Gedächtnisstörungen vorbereitet, während eine Kontrollgruppe (n = 10) optimale Testanstrengung zeigen sollte. Alle SVT führten im Gegensatz zu den Simulationsmarkern des TMT und der SPM zu einer ausgezeichneten Klassifikationsgüte (95-100 %). Die neuropsychologischen Leistungsmaße wiesen zwar signifikante Gruppenunterschiede aus, zeigten aber auch eine nicht unbedeutende Überlappung der Verteilungen. Mehr Studien sind notwendig, um den SVT in den deutschsprachigen Ländern den Platz zu sichern, den sie international aktuell in der klinisch-neuropsychologischen Forschung und Praxis einnehmen.

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