scholarly journals Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0254590
Author(s):  
Qiqi Shi ◽  
Ran Wang ◽  
Huifeng Zhang ◽  
Yaping Shan ◽  
Ming Ye ◽  
...  

SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age examined in the 2001–2018 National health and Nutrition Examination Survey. We examined the association between SUA and CVD risk factors. The overall mean SUA level was 5.00±1.24mg/dl. Restricted cubic spline analysis results revealed SUA was inversely associated with HDL-C and SPISE and positively associated with TC, TG, LDL-C, nonHDL-C, insulin, SBP and DBP after full adjustment. Multiple logistic analyses showed SUA level was independently associated with high TC, high TG, high nonHDL-C and low HDL-C (all p<0.05). Furthermore, females in the highest quartile of SUA had significantly higher odds for elevated BP (OR = 2.38, 95%CI:1.02–5.54, P<0.05) and high TC (OR = 2.22, 95%CI: 1.49–3.30, P<0.001), which not observed in males. Increased levels of SUA were associated with increased odds of various cardiovascular risk factors in American adolescents, especially females.

2020 ◽  
Vol 42 (12) ◽  
pp. 1031-1041 ◽  
Author(s):  
Beverly M. Hittle ◽  
Claire C. Caruso ◽  
Holly J. Jones ◽  
Amit Bhattacharya ◽  
Joshua Lambert ◽  
...  

Extreme chronotype and circadian disrupting work hours may increase nurse disease risks. This national, cross-sectional study of nurses ( N = 527) had three hypotheses. When chronotype and shift times are incongruent, nurses will experience increased likelihood of (1) obesity, (2) cardiovascular disease/risk factors, and (3) obesity or cardiovascular disease/risk factors when theoretically linked variables exist. Chronotype mismatched nurses’ ( n = 206) average sleep (6.1 hours, SD = 1.2) fell below 7–9 hours/24-hours sleep recommendations. Proportion of male nurses was significantly higher chronotype mismatched (12.3%) than matched (6.3%). Analyses found no direct relationship between chronotype match/mismatch with outcome variables. Exploratory interaction analysis demonstrated nurses with mismatched chronotype and above average sleep quality had an estimated 3.51 times the adjusted odds (95% CI 1.52,8.17; p = .003) of being obese. Although mechanism is unclear, this suggests sleep quality may be intricately associated with obesity. Further research is needed to inform nurses on health risks from disrupted sleep, chronotypes, and shift work.


PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0162753 ◽  
Author(s):  
Nuri Kodaman ◽  
Melinda C. Aldrich ◽  
Rafal Sobota ◽  
Folkert W. Asselbergs ◽  
Kwabena A. Poku ◽  
...  

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