scholarly journals The Management and Outcome of Higher Order Multifetal Pregnancies: Obstetric, Neonatal and Follow-up Data

Twin Research ◽  
2001 ◽  
Vol 4 (1) ◽  
pp. 4-11
Author(s):  
Mark H. Yudin ◽  
Elizabeth V. Asztalos ◽  
Ann Jefferies ◽  
Jon F.R. Barrett
Keyword(s):  
Statistical Analysis ◽  
Motor Skills ◽  
Gestational Age ◽  
Neurodevelopmental Outcome ◽  
Higher Order ◽  
Neurodevelopmental Outcomes ◽  
Significant Difference ◽  
Before And After

AbstractThe objective of this study was to describe current obstetric, neonatal, and long-term neurodevelopmental outcomes of higher order multifetal gestations (≥ 3 fetuses) in the 1990s. We also intended to identify a target gestational age at which neonatal and neurodevelopmental morbidities are low. Records from all multifetal pregnancies (≥ 3 viable fetuses ≥ 20 weeks gestation) delivered at the two perinatal centers in Toronto, Ontario, Canada during the study period (January 1, 1990–December 31, 1996) were reviewed. Data were collected on obstetric, neonatal, and long-term neurodevelopmental outcomes. Follow up data were gathered regarding the presence of a severe deficit in four categories (vision, hearing, cognition, and motor skills). Statistical analysis was performed to determine a gestational age at which a significant decrease in deficit occurred. During the study period 165 multifetal pregnancies were delivered. This resulted in 511 fetuses, of which 496 were live births. Of these 496 infants, 453 survived to discharge. Follow up data were obtained on 332 (73.3 per cent) infants. Infant survival increased with gestational age, and was approximately 90 per cent or greater at 26 weeks or more. Of all infants followed, the proportion of those without deficit increased with increasing gestational age, such that the per cent without deficit was 96.9 at 31 weeks or greater. Of all infants followed, 301 (90.7 per cent) had no deficit. Statistical analysis revealed a significant difference in long-term neurodevelopmental outcome between infants born before and after 28 weeks gestation. The incidence of a major deficit was 44.1 per cent for those born earlier than and 5.4 per cent for those born later than this gestational age (p = 0.001). In our cohort, survival figures were high. Even in lower gestational groupings, survival was high, but not without serious concerns about severe morbidity. This information is useful when counseling parents of higher order multifetal pregnancies.

scholarly journals Long-Term Neuropsychological Outcome in Preterm Twins

2006 ◽  
Vol 6 ◽  
pp. 899-907 ◽  
Author(s):  
Giovanni Iannone ◽  
Clelia Tripaldi ◽  
Antonino Chindemi ◽  
Lorenzo Piscitelli ◽  
Antonio Mastrorocco ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Statistical Analysis ◽  
Gestational Age ◽  
Comparison Group ◽  
Sample Population ◽  
Ophthalmological Examination ◽  
Neuropsychological Outcome ◽  
Significant Difference

Few long-term studies have yet described neuropsychological outcome in preterm twins. Our aim was to assess, by long-term evaluation, neuropsychological outcome in preterm twins in order to define a correct follow-up program. Our study was a cohort one, with an index and a comparison group. Neonatal medical records of all preterm newborns admitted to our centre between 1991 and 1997 were reviewed and selected patients were recalled. The sample population included two matched groups of children aged 6—12 years, 86 twins and 86 singletons, submitted to paediatric, neurological, psychological, and ophthalmological examinations. Inclusion criteria were twin pregnancy and gestational age 27—36 weeks for index group; same gestational age, but single pregnancy, for the comparison group. All children underwent paediatric and neuropsychiatric examinations, cognitive assessment, and psychological evaluation by standardized tests for screening of learning specific disorders and language difficulties, and finally, ophthalmological examination. In order to study their role in predicting neuropsychological outcome, we examined some perinatal prognostic factors by statistical analysis. Unfavourable neuropsychological outcome was observed in 55/172 (32%) children, with different prevalence in the two groups, 42/172 (24%) in twins and 13/172 (8%) in singletons. Statistical analysis performed for examined prognostic factors showed significant differences in neuropsychological outcome with regard only to gestational age < 32 weeks, low birth weight, intraventricular haemorrhage, and periventricular leukomalacia. The incidence of neuropsychological diseases in the two groups showed significant difference about language and learning difficulties. Our data suggest that preterm twins represent a particular high-risk category of premature babies, mostly regarding the risk of so-called “minimal brain dysfunction”, so a careful follow-up is recommended.

Comparative Analysis of Patients with Robotic Hiatal Hernia Repairs with and without Collis Gastroplasty

2021 ◽  
pp. 000313482198905
Author(s):  
John A. Perrone ◽  
Stephanie Yee ◽  
Manrique Guerrero ◽  
Antai Wang ◽  
Brian Hanley ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Statistical Analysis ◽  
Hospital Stay ◽  
Hiatal Hernia ◽  
Collis Gastroplasty ◽  
Significant Difference ◽  
Related Quality

Introduction After extensive mediastinal dissection fails to achieve adequate intra-abdominal esophageal length, a Collis gastroplasty(CG) is recommended to decrease axial tension and reduce hiatal hernia recurrence. However, concerns exist about staple line leak, and long-term symptoms of heartburn and dysphagia due to the acid-producing neoesophagus which lacks peristaltic activity. This study aimed to assess long-term satisfaction and GERD-related quality of life after robotic fundoplication with CG (wedge fundectomy technique) and to compare outcomes to patients who underwent fundoplication without CG. Outcomes studied included patient satisfaction, resumption of proton pump inhibitors (PPI), length of surgery (LOS), hospital stay, and reintervention. Methods This was a single-center retrospective analysis of patients from January 2017 through December 2018 undergoing elective robotic hiatal hernia repair and fundoplication. 61 patients were contacted for follow-up, of which 20 responded. Of those 20 patients, 7 had a CG performed during surgery while 13 did not. There was no significant difference in size and type of hiatal hernias in the 2 groups. These patients agreed to give their feedback via a GERD health-related quality of life (GERD HRQL) questionnaire. Their medical records were reviewed for LOS, length of hospital stay (LOH), and reintervention needed. Statistical analysis was performed using SPSS v 25. Satisfaction and need for PPIs were compared between the treatment and control groups using the chi-square test of independence. Results Statistical analysis showed that satisfaction with outcome and PPI resumption was not significantly different between both groups ( P > .05). There was a significant difference in the average ranks between the 2 groups for the question on postoperative dysphagia on the follow-up GERD HRQL questionnaire, with the group with CG reporting no dysphagia. There were no significant differences in the average ranks between the 2 groups for the remaining 15 questions ( P > .05). The median LOS was longer in patients who had a CG compared to patients who did not (250 vs. 148 min) ( P = .01). The LOH stay was not significantly different ( P > .05) with a median length of stay of 2 days observed in both groups. There were no leaks in the Collis group and no reoperations, conversions, or blood transfusions needed in either group. Conclusion Collis gastroplasty is a safe option to utilize for short esophagus noted despite extensive mediastinal mobilization and does not adversely affect the LOH stay, need for reoperation, or patient long-term satisfaction.

scholarly journals GROWTH, NEURODEVELOPMENT IN EXTREMELY LOWBIRTH BABIES AT TWO YEAR OF CORRECTED AGE

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Ashok Kumar ◽  
Dr. Kanya Mukhopadhyay ◽  
Dr. Prabhjot Malhi ◽  
Dr. Anil Kumar Bhalla
Keyword(s):  
Birth Weight ◽  
Neurological Examination ◽  
Gestational Age ◽  
Head Circumference ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Catch Up

According to national neonatal perinatal data (NNPD) the survival of ELBW babies has improved from 37% in 2000 to 45% in 2002-3 reports. In our neonatal unit in PGIMER the survival of ELBW babies has been 54-56% in last 5 years, however unfortunately there is very scanty reports of long term outcome of ELBW babies from India. There is very scanty report of long term growth outcome of VLBW and ELBW Babies in our country, we reported VLBW and ELBW babies in our follow up had poor catch up growth, though some catch-up was observed at 6 month but subsequent lag in growth probably reflects poor weaning at 1 year.  Infants with extremely low birth weights (ELBWs) are more susceptible to all of the possible complications of premature birth, both in the immediate neonatal period and after discharge from the nursery. These babies are at risk of poor growth and developmental. in the present study a total of 39 cases of ELBW Babies were enrolled during one year study period from July 2011- June2012 attending the neonatal follow up clinic attained 2year±3month of corrected age. Their detail birth data and postnatal illnesses retrieved from their initial hospital files and unit discharge record. A similar number of babies enrolled at 2yrs±3months of age in the control group. In the presence study, we assessed the growth, and neurological out come in extremely low birth baby attained 2yrs±3 months of corrected age. The study population consisted of 39 children of ELBW baby born during 2009 -10 at PGIMER & same number of normal birth weight children at 2yr±3 months of corrected age who satisfied the inclusion and exclusion criteria. These children were enrolled from neonatal follow up clinic who were already undergoing long term follow up. For growth outcome, we used weight, height & head circumference measurement of child, for neurological and developmental outcome used clinical neurological examination and DP-III .Base line demographic characteristics of our ELBW babies (Cases) where as follows.   Mean (S.D) gestational age of  ELBW babies was 29.87±2.3 week. Mean (S.D) birth weight 867±71.1 grams, Mean (S.D) lenght35±2.1cm & head circumference was 25.76±1.9 cm. Mean hospital stay in the ELBW babies was 48.6±19.9 days. Mean birth weight and gestational age of control group where 2684±166.2grm and 39.03±0.9 weeks. At 2year of corrected age we found  - Weight was similar in both in case group & control group. (10.04±1.4 Vs 10.75±1.1). Height and head circumference were smaller in cases than control group. (81.4±4.3 Vs 84.4±3.3 and 45.9±1.6 Vs 46.8±1.5. 5% Babies had cerebral palsy in case group (N=2/39) and none in control group. Gross development score(GDS) in Development profile-III in both study group (cases & controls) was  similar  (72.49±8.08 Vs 73.54±9.3,p=0.596). Significant difference in domains physical (84.5±7.8 Vs.90±3.5, p=0.000) and domains adaptive (81±6.7 Vs. 85.3±5.4,p= 0.003) in cases as compared to controls. There was no difference between SGA and AGA among cases in growth and neurological development. There was no difference between male and female in case group in any parameter .There is very scanty data from our country on longterm follow up of ELBW babies. Our data shows that our ELBW cohort remained small in height and had smaller head circumference though weight was similar as compared to normal control babies.  Key words: ELBW, VLBW, birth weight, neurological examination.

scholarly journals Clinical efficacy of single intraoperative 500 mg methylprednisolone management therapy for thoracic myelopathy caused by ossification of the ligamentum flavum

2020 ◽  
Author(s):  
Xiaoyang Huo ◽  
Jiaming Zhou ◽  
Shiwei Liu ◽  
Xing Guo ◽  
Yuan Xue
Keyword(s):  
Posterior Approach ◽  
Ligamentum Flavum ◽  
Thoracic Myelopathy ◽  
Time Points ◽  
Significant Difference ◽  
Before And After ◽  
Long Term Follow Up ◽  
Frankel Grade

Abstract Background: The objective of our study was to compare clinical outcome and postoperative complications between patients with thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) treated with and without intraoperative methylprednisolone (MP).Methods: This retrospective study enrolled 101 patients who underwent posterior approach surgery for OLF and were followed up at least 1 year. Patients were divided into two groups according to MP use in the operation: MP group (n=47) and non-MP group (n=54). Clinical outcomes and complications were evaluated before and after operation and at the last follow-up. Results: Significant differences were found in modified Japanese Orthopedics Association (mJOA) scores and proportion of Frankel grade (A-C) between the two groups immediately after surgery and at 2-week follow-up. No significant differences were found between the two groups in mJOA score before operation and at the final follow-up. Moreover, no significant differences were observed in recovery rate according to mJOA score at any time points, and there was no significant difference in the proportion of Frankel grade (A-C) between the two groups at final follow-up. There were 13 documented infections: 10 in the MP group and 3 in the non-MP group (P=0.034).Conclusion: Management therapy with intraoperative 500 mg MP showed better recovery of nerve function within 2 weeks in patients with thoracic myelopathy caused by OLF compared with those did not receive MP. However, long-term follow-up results showed that there was no significant difference in neurological recovery between patients with intraoperative MP or not. Moreover, intraoperative MP increased the rate of wound infection.

scholarly journals Influence of the level of maternal education on the long-term neurodevelopmental outcome of Saudi infants with birth weight of 1000-1500 grams at the age of 21-24 months

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Badr Hasan Sobaih
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Maternal Education ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcome ◽  
University Hospital ◽  
Vlbw Infants

Background: Advancements in perinatal-neonatal care in the last decades has led to improved survival rates of very-low birth weight (VLBW) infants. An association between the level of maternal education and neurodevelopmental outcome has been demonstrated in many European studies. This study evaluates the influence of maternal education level and socio-demographic status on the long-term development of Saudi VLBW infants with birth weight of 1000-1500 grams at a corrected gestational age of 21-24 months. Method: This retrospective cohort study examined prospectively collected data from the period of 2005 to 2016 from the Neonatal Follow-up Program (NFP) at King Khalid University Hospital in Riyadh, Saudi Arabia. Results: A total of 122 VLBW infants with a mean gestational age of 29.57 weeks and mean birth weight 1265 grams were enrolled. There was no statistically significant association between the level of maternal education and neurodevelopmental screening outcome at the age of 21-24 months according to the Bayley Infant Neurodevelopmental Screener (BINS) (p=0.149). Bronchopulmonary dysplasia (BPD) was highly associated with cerebral palsy (p=0.001) and an abnormal BINS score (p=0.010). Conclusion: There was no significant influence of the level of maternal education on the neurodevelopmental screening outcome of VLBW infants at the corrected age of 21-24 months. BPD was the strongest predictor of adverse neurodevelopmental outcome. Keywords: Bayley Infant Neurodevelopmental Screener (BINS), Neurodevelopmental Outcome, Maternal educational level, Neonatal follow-up program (NFP), Very Low Birth Weight (VLBW) infant.

scholarly journals P964 Assessment of long-term durability of transcatheter implanted aortic valves - structural and nonstructural deteriorations in 5 years follow-up

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
H Linkova ◽  
R Petr ◽  
E Paskova ◽  
V Kocka ◽  
P Tousek
Keyword(s):  
Young Patients ◽  
Transcatheter Aortic Valve ◽  
Clinical Complications ◽  
Structural Deterioration ◽  
Significant Difference ◽  
Before And After ◽  
Echocardiographic Examination ◽  
Valve Implantation

Abstract Introduction Transcatheter aortic valve implantation (TAVI) is the method of choice for patient with a significant stenosis (AS) who are contraindicated for cardio-surgical procedure. Medium – term results of TAVI are comparable with results observed for surgical replacements. There is limited knowledge of structural, nonstructural and clinical complications in five years follow-up which could contribute to TAVI indication for implantation in young patients. Goal. The aim of this study is to assess structural and non-structural deterioration of TAVI prosthesis by echocardiography and clinical evaluation at 5 years follow-up. Methods By the end of 2013, 112 patients were implanted TAVI in our center( average age, 80,4 ± 7,2 y, 53(47% ) males. All patients underwent both clinical and echocardiographic examination once a year and underwent native CT after five year. We analysed mortality, structural and non- structural deteriorations, and standard echocardiographic parameters before and after implantation, and at 5 years follow-up. Results 5-years mortality was 58%. There was not a statistically significant difference in age between the patients who survive and who died (80,2 ±7,3 vs 80,6 ± 7,3 p = 0.77) ,they had similar logistic EUROSCORE (17,0 ± 12,4 vs 16,9 ± 15,0, p = 0,96) and EF 53,8 ± 11,1 vs 52,3 ± 11,7,p= 0,51) before the procedure. 48 patients underwent the five years follow –up. Only one patient had to undergo reTAVI due to the earlier prosthetic degeneration. The average EOA was 1,88 ± 0,33 cm2), the average V max. after five years was 1,8 ± 0,4 m/s, PG max 13,6 ± 6,2 mm Hg a PG mean 8 ± 3,6 mm Hg ( no significant increase in time),Post procedural paravalvular regurgitation ≥ 2/4 appeared in 14 % patients. Twenty –three patients underwent CT scan which resulted in Agaston score O on TAVI replacement in 19(83 %) patients. Conclusion After 5 years follow-up, low rates of structural and nonstructural deterioration after TAVI were noted, suggesting good long- term durability.

Long-Term Neurodevelopmental Outcomes of Neonatal Chikungunya: Follow-Up of a Series of Cases Till 1 Year

2020 ◽  
Author(s):  
Amlin Shukla ◽  
Tapas Bandyopadhyay ◽  
Nagaratna Vallamkonda ◽  
Arti Maria
Keyword(s):  
Primary Outcome ◽  
Neurodevelopmental Outcome ◽  
Secondary Outcome ◽  
Developmental Assessment ◽  
Neurodevelopmental Outcomes ◽  
Assessment Scales ◽  
Development Quotient ◽  
Anthropometric Assessment

Abstract Objectives Short- or long-term neurodevelopmental outcomes of Neonatal Chikungunya infection haven’t been well described. In this study, we describe neurodevelopmental outcomes of a series of 13 infants. Methods Study was conducted over a period of 1 year in high-risk follow-up clinic. Follow-up visits were conducted at 3, 6, 9, 12 ± 3 months. Primary outcome Development Quotient by Developmental Assessment Scales for Indian Infants. Secondary outcome: growth/anthropometric assessment, neuromotor/neurosensory and re-hospitalization rate. Results DASII was &lt;85 in three infants. Two other had expressive speech delay. Two, three and four babies had head circumference, length and weight below third centile, respectively. Two infants had persistent hypertonia and one had hypotonia. Two infants developed strabismus. Two infants had seizures persisting at 12 months requiring re-hospitalization. Conclusion Neonatal Chikungunya infection portends a poor neurodevelopmental outcome at 1 year of age. Careful neurodevelopmental follow-up is required for identification and management of sequelae.

Abstract 13400: Patients Less Than or Equal to 2.5kg Have Higher Morbidity and Mortality After Norwood-sano Palliation

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Konstantin Averin ◽  
Lindsay Ryerson ◽  
Morteza Hajihosseini ◽  
Irina A Dinu ◽  
Darren H Freed ◽  
...  
Keyword(s):  
Chromosomal Abnormalities ◽  
Morbidity And Mortality ◽  
Norwood Operation ◽  
Neurodevelopmental Outcomes ◽  
Low Weight ◽  
Significant Difference ◽  
Motor Outcomes ◽  
Cardiac Diagnosis

Introduction: In patients with single ventricle heart disease, prematurity and low weight at the Norwood operation are risk factors for mortality. Reports assessing peri-operative and long-term outcomes of Norwood palliation in patients ≤ 2.5kg are limited. Methods: All patients who underwent Norwood-Sano procedure between 2005-2020 were identified. Patients ≤ 2.5kg at the time of the Norwood operation (cases) were matched 1:3 with patients ≥ 3.0 kg (comparisons) for year of surgery and cardiac diagnosis. Demographic and peri-operative characteristics, survival to hospital discharge and 2-year neurodevelopmental outcomes were compared. Results: Twenty-seven cases (mean±SD weight 2.2±0.3 kg, mean age 15.6±14.1 days at surgery) and 81 comparisons (mean weight 3.5±0.4 kg, mean age 10.9±7.9 days at surgery) were identified. There was no statistically significant difference in the presence of chromosomal abnormalities (7.4% vs. 12.3%, p=0.485), prenatal diagnosis made (88.9% vs. 75.3%, p=0.141), or duration of cardiopulmonary bypass (140.7±65.6 vs. 121.3±42.3 min, p=0.068) between cases and comparisons, respectively. Cases had a longer time to post-operative lactate < 2 mmol/L (33.1±27.5 vs. 17.9±12.2 hours, p<0.001), longer duration of ventilation (30.5±24.5 vs. 18.6±17.5 days, p=0.005), higher need for dialysis (48.1% vs. 19.8%, p=0.007) and greater need for extracorporeal membrane oxygenation support (29.6% vs. 12.3%, p=0.004). Cases also had significantly higher in-hospital (25.9% vs. 1.2%, p<0.001) and 2-year (59.2% vs. 11.1%, p<0.001) mortality. The 2-year Bayley Scales of Infant and Toddler Development, III, was completed on all living cases (n=11) and most comparisons (n=63; 1 refusal and 8 too young); delay, a score of < 70, showed the following differences between cases vs. comparisons for cognitive (86.9 vs. 91, p=0.363), language (84.9 vs. 88.2, p=0.494) and motor (73.6 vs. 87.3, p=0.013). Conclusions: Patients ≤ 2.5kg at the time of Norwood-Sano have significantly higher post-operative morbidity and mortality up to 2-year follow-up, and worse 2-year neurodevelopmental motor outcomes. Additional studies are warranted to assess the outcome of alternative therapeutic options in this patient population.

scholarly journals Neurodevelopmental Outcome in Extremely Low Birth Weight Infants at 2–3 Years of Age

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 649
Author(s):  
Maria Kyriakidou ◽  
Ilias Chatziioannidis ◽  
Georgios Mitsiakos ◽  
Sofia Lampropoulou ◽  
Abraham Pouliakis
Keyword(s):  
Neonatal Intensive Care ◽  
Cranial Nerves ◽  
Neurodevelopmental Outcome ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Neurodevelopmental Outcomes ◽  
Motor Delay ◽  
Neurological Outcomes

Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of age. Materials and methods: In our single-centre longitudinal cohort study, of the 73 consecutive infants admitted to our Neonatal Intensive Care Unit (NICU), 49 infants (80%) received both Hammersmith Infant Neurological Examination (HINE) at 3- and 6-months corrected age and Bayley–III neurodevelopmental assessment at 2–3 years chronological age. At 3 months follow up, 8.2% had suboptimal scores (below 10th percentile) on the HINE. At 6 months follow up, 4.1% had suboptimal scores (below 10th percentile) on the HINE. The means(±SD) for Bayley-III cognitive, language, and motor subscales were (96.3 ± 9.8), (99.9 ± 11.9), (93.2 ± 9.9). Results: At 3 months corrected age, higher total HINE scores and subscores for function of cranial nerves, posture, tone, were associated with better cognitive scores while poorer scores for function of cranial nerves, posture, movements, tone, and total HINE score were associated with lower motor scores. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have three times higher odds of having a motor delay. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have more than two times higher odds of having a language delay. At 6 months corrected age, poorer scores for function of cranial nerves, movements, tone, reflexes, and total HINE score were associated with worse Bayley-III motor scores whilst infants who have a total HINE score and a subscore of reflexes in the suboptimal range have four and seven times, respectively, higher odds of having a motor delay. Conclusions: Early identification of infants at risk for adverse long-term outcomes is essential in introducing early intervention therapies for optimizing neurodevelopmental outcomes.

scholarly journals Neurodevelopmental Outcome of Infants with Gastroschisis at One-Year Follow-Up

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Vishal Gupta ◽  
Amit Trivedi ◽  
Karen Walker ◽  
Andrew JA Holland
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Surgical Repair ◽  
Neurodevelopmental Outcome ◽  
Control Group ◽  
Developmental Assessment ◽  
Neurodevelopmental Outcomes ◽  
One Year ◽  
Assessment Results

Objective: Gastroschisis is a congenital malformation of the abdominal wall and may be associated with significant neonatal mortality and morbidity. The primary objective of this study was to describe the neurodevelopmental outcomes of neonates with this condition.Methods: Medical records of all neonates admitted with a diagnosis of gastroschisis to a tertiary surgical unit from October 2006 to August 2011 were retrospectively reviewed. Demographic and clinical variables were collated along with developmental assessment results at one-year follow-up. Developmental assessment results were compared with case matched healthy control neonates of similar gestational age and birth weight.Results: Of 20 patients in the study, 16 had simple and four had complex gastroschisis. Mean birth weight was 2.29 kg with a mean gestational age of 35.7 weeks. The majority of neonates underwent primary surgical repair, while 15% had a silo followed by surgical repair. Neonates with gastroschisis did not significantly differ from the control group in neurodevelopmental outcomes. Receptive and expressive language delay was found in gastroschisis is attributable to small for gestational age rather than the malformation per se.Conclusions: These data suggest that neurodevelopmental outcomes at one year of age in children with gastroschisis were associated with being small for gestational age rather than the malformation.

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