scholarly journals HEART-TYPE FATTY ACID-BINDING PROTEIN (H-FABP) AS A NOVEL BIOMARKER FOR THE EARLY DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION IN COMPARISON WITH CARDIAC TROPONIN T

2013 ◽  
Vol 2 (1) ◽  
pp. 8-18 ◽  
Author(s):  
Jagadish H.Ramaiah ◽  
Raghu T. Ramegowda ◽  
Bharatha Ashalatha ◽  
Rajiv Ananthakrishna ◽  
Manjunath C.Nanjappa.
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Early Diagnosis ◽  
Cardiac Troponin ◽  
Fatty Acid Binding Protein ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction

1997 ◽  
Vol 43 (8) ◽  
pp. 1372-1378 ◽  
Author(s):  
Junnichi Ishii ◽  
Jian-hua Wang ◽  
Hiroyuki Naruse ◽  
Shinn Taga ◽  
Masatomo Kinoshita ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Early Diagnosis ◽  
Healthy Volunteers ◽  
Human Heart ◽  
Fatty Acid Binding Protein ◽  
Serum Concentrations ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Abstract We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95% confidence interval (CI) = 0.913–0.979] and myoglobin (0.895, 95% CI = 0.846–0.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.765–0.881). In 165 patients, the sensitivity (81.8%, 95% CI = 74.2–89.4%), specificity (86.4%, 95% CI = 78.1–94.6%), and predictive accuracy (83.6%, 95% CI = 78.0–89.3%) of H-FABPc >12 μg/L in diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABPc >12 μg/L and the ratio ≤14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.

Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction

2016 ◽  
Vol 7 (6) ◽  
pp. 561-569 ◽  
Author(s):  
Masaru Obokata ◽  
Tatsuya Iso ◽  
Yoshiaki Ohyama ◽  
Hiroaki Sunaga ◽  
Tomoka Kawaguchi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Troponin T ◽  
Binding Protein ◽  
Serum Fatty Acid ◽  
Metabolic Complications ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Background: Acute myocardial infarction (AMI) induces marked activation of the sympathetic nervous system. Fatty acid binding protein 4 (FABP4) is not only an intracellular protein, but also a secreted adipokine that contributes to obesity-related metabolic complications. Here, we examined the role of serum FABP4 as a pathophysiological marker in patients with AMI. Methods and results: We studied 106 patients presenting to the emergency unit with a final diagnosis of AMI, including 12 patients resuscitated from out-of-hospital cardiac arrest (OHCA) caused by ventricular fibrillation. FABP4 levels peaked on admission or just after percutaneous coronary intervention and declined thereafter. Regression analysis revealed no significant correlation between peak FABP4 and peak cardiac troponin T determined by Roche high-sensitive assays (hs-TnT). Notably, FABP4 levels were particularly elevated in AMI patients who were resuscitated from OHCA (median 130.2 ng/mL, interquartile range (IQR) 51.8–243.9 ng/mL) compared with those without OHCA (median 26.1 ng/ml, IQR 17.1–43.4 ng/mL), while hs-TnT levels on admission were not associated with OHCA. Immunohistochemistry of the human heart revealed that FABP4 is abundantly present in adipocytes within myocardial tissue and epicardial adipose tissue. An in vitro study using cultured adipocytes showed that FABP4 is released through a β3-adrenergic receptor (AR)-mediated mechanism. Conclusions: FABP4 levels were significantly elevated during the early hours after the onset of AMI and were robustly increased in OHCA survivors. Together with the finding that FABP4 is released from adipocytes via β3-AR-mediated lipolysis, our data provide a novel hypothesis that serum FABP4 may represent the adrenergic overdrive that accompanies acute cardiovascular disease, including AMI.

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