scholarly journals Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers

2011 ◽  
Vol 16 (1) ◽  
pp. 3
Author(s):  
Sandra Bragança Coelho ◽  
Patrícia G Cardoso ◽  
Josefina Bressan ◽  
Neuza MB Costa ◽  
Rita CG Alfenas
Keyword(s):  
Gene Polymorphism ◽  
Normal Weight ◽  
Grasa Corporal ◽  
Promoter Gene ◽  
Plasma Leptin

Introducción: Identificar polimorfismos en la región promotora del gen del receptor de la leptina en los individuos con peso normal e investigar si este polimorfi smo afecta a las respuestas hormonales y el apetito tras la ingesta de cacahuetes o una mezcla de ingredientes con un aporte de macronutrientes semejante.Material y método: Se controló el apetito, los índices antropométricos, la composición corporal, la actividad física, la ingesta dietética y las concentraciones de leptina, grelina e insulina de todos los sujetos. Además, se llevaron a cabo los análisis de polimorfi smo.Resultados: Ninguno de los tratamientos dio lugar a una diferencia estadísticamente signifi cativa en las hormonas analizadas. No se encontró polimorfi smo del gen del receptor de leptina, pero para el gen de la leptina, el 50% de los voluntarios tenían un alelo polimórfi co y el 13%, dos. Estos presentaron menores índices de masa grasa corporal, concentraciones plasmáticas de leptina y grelina y tasas de plenitud gástrica. Asimismo, tenían más hambre, deseo de comer y deseo de comer algo dulce y salado.Conclusiones: Ingerir cacahuetes no afecta al apetito y no produce respuestas hormonales diferentes que con otros alimentos estudiados. Los portadores de alelos polimórficos en los dos alelos tuvieron mayor probabilidad de sufrir obesidad, aunque no ha sido posible evaluar su magnitud.

scholarly journals Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers

2012 ◽  
Vol 16 (1) ◽  
pp. 3-9
Author(s):  
Sandra B. Coelho ◽  
Patrícia G. Cardoso ◽  
Josefina Bressan ◽  
Neuza M.B. Costa ◽  
Rita C.G. Alfenas
Keyword(s):  
Gene Polymorphism ◽  
Normal Weight ◽  
Promoter Gene ◽  
Plasma Leptin

scholarly journals Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men

2001 ◽  
Vol 25 (1) ◽  
pp. 106-114 ◽  
Author(s):  
NF Chu ◽  
MJ Stampfer ◽  
D Spiegelman ◽  
N Rifai ◽  
GS Hotamisligil ◽  
...  
Keyword(s):  
Lifestyle Factors ◽  
Normal Weight ◽  
Plasma Leptin

scholarly journals Leptin G-2548A Gene Polymorphism is Positively Associated with Increased Plasma Leptin and Glucose Levels in Obese Saudi Patients Irrespective Status of Blood Pressure    

2021 ◽  
Author(s):  
Lotfi S. Bin Dahman ◽  
Nasser M. Al-Daghri
Keyword(s):  
Blood Pressure ◽  
Gene Polymorphism ◽  
Plasma Glucose ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Lep Gene ◽  
Plasma Leptin ◽  
Saudi Patients

Abstract The association between LEP G-2548A gene polymorphism with increased plasma leptin and glucose levels and blood pressure in a sample of obese Saudi patients has been evaluated. This is a cross-sectional study involved 206 Saudi adult subjects (94 males and 112 females), randomly selected from the primary health care centers, Riyadh, Saudi Arabia. The study sample was categorized into three groups: 50 normotensive ND controls (age: 47.9±5.4 yr.; BMI 22.9±2.1 Kg/m2), 80 obese normotensive ND (age: 47.7±6.0 yr.; BMI 34.1±4.2 Kg/m2) and 76 obese hypertensive with T2D patients (age: 49.4±5.9 yr.; BMI: 35.1±4.7 Kg/m2). Analyses of LEP G-2548A gene polymorphism were determined using polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP) with 2U of HhaI restriction enzyme. Plasma leptin and insulin levels were measured using the Luminex instrument. Fasting plasma glucose, total cholesterol, HDL-cholesterol, and triglycerides were measured using a chemical autoanalyzer Konelab machine. Also, blood pressure and anthropometric data were measured. The association analysis with metabolic parameters showed that homozygous AA of the LEP gene had significantly higher plasma glucose levels and HOMA-IR compared with homozygous GG (6.8±0.55 vs. 5.8±0.30; p< 0.04; 4.1±0.84 vs. 2.6±0.67; p=0.03) respectively. Besides, heterozygous GA had significantly higher plasma leptin levels compared with homozygous GG (40.0±2.6 vs. 29.6±2.6; P= 0.04). GA, AA, GA+AA genotypes of the LEP G-2548A gene polymorphism are more prevalent among individuals with hyperglycemia (OR= 3.7, 95% CI= 1.6 to 8.4, P= 0.001; OR= 3.2, 95% CI= 1.2 to 8.6, P= 0.03; OR= 3.5, 95%CI= 1.6 to 7.7, P= 0.001) respectively. A allele of the LEP gene is more prevalent among subjects with hyperglycemia (OR= 1.9, 95%CI= 1.2 to 3.0, P=0.006). G-2548A variant of the LEP gene may not be considered as a genetic risk factor for hypertension in Saudi obese patients. However, the genotypes (GA and AA) and -2548AA allele of this gene may represent important risk factors predisposing healthy subjects to develop T2DM irrespective of the status of blood pressure.

scholarly journals The levels of adipokines in relation to hormonal changes during the menstrual cycle in young, normal-weight women

2017 ◽  
Vol 6 (8) ◽  
pp. 892-900 ◽  
Author(s):  
Katarzyna Wyskida ◽  
Grzegorz Franik ◽  
Tomasz Wikarek ◽  
Aleksander Owczarek ◽  
Alham Delroba ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Multivariate Regression ◽  
Normal Weight ◽  
Total Testosterone ◽  
Hormonal Changes ◽  
Regression Analyses ◽  
Anthropometric Parameters ◽  
Tnf Α ◽  
Plasma Leptin

Context The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women. Methods The study involved 52 young, healthy, normal-weight women. Anthropometric parameters, body composition and levels of plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 in addition to serum FSH, LH, estradiol, progesterone, 17-OH progesterone, androgens, SHBG and insulin concentrations were measured during a morning in fasting state three times: between days 2–4, days 12–14 and days 24–26 of the menstrual cycle. Results Plasma adiponectin, omentin-1, resistin and visfatin/NAMPT, apelin, TNF-α, IL-6 and RBP4 concentrations were stable during the menstrual cycle, while leptin and vaspin levels were significantly higher in both the midcycle and the luteal phases than those in the follicular phase. Multivariate regression analyses revealed that changes in leptin and vaspin levels between the follicular and the luteal phase are strongly related to changes in total testosterone levels. Conclusions Our results revealed stable levels of adipokines during the phases of the physiological menstrual cycle, except for leptin and vaspin, which showed increased levels in both the midcycle and the luteal phases. This effect was significantly associated with changes in the secretion of testosterone, 17-OH progesterone and insulin in the luteal phase.

TUMOUR NECROSIS FACTOR ALPHA PROMOTER GENE POLYMORPHISM IN SARCOIDOSIS

Cytokine ◽  
1997 ◽  
Vol 9 (10) ◽  
pp. 787-790 ◽  
Author(s):  
Ulrike Seitzer ◽  
Cezary Swider ◽  
Frank Stüber ◽  
Krzysztof Suchnicki ◽  
Andrzej Lange ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Necrosis Factor Alpha ◽  
Promoter Gene ◽  
Factor Alpha ◽  
Necrosis Factor
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