scholarly journals S1194 Risk of Drug-Induced Liver Injury in Patients With Chronic Hepatitis B and Active Tuberculosis Co-Infection: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 116 (1) ◽  
pp. S554-S555
Author(s):  
Christina Chou ◽  
Nicolette Veracruz ◽  
Amit S. Chitnis ◽  
Robert Wong
Keyword(s):  
Systematic Review ◽  
Chronic Hepatitis ◽  
Liver Injury ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Meta Analysis ◽  
Active Tuberculosis ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Analysis of Clinical Characteristics and Chronic Factors of Drug-induced Liver Injury in Chronic Hepatitis B Infection: A Retrospective Study

2021 ◽  
Vol 21 (9) ◽  
Author(s):  
Yan jie Lin ◽  
Meng jiao Xu ◽  
Wei Yi ◽  
Fang Fang Sun ◽  
Zhan Zeng ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Injury ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Roc Curve ◽  
Predictive Value ◽  
Clinical Characteristics ◽  
Hbv Infection ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Background: This study investigated clinical characteristics and chronic factors of drug-induced liver injury (DILI) among patients with chronic hepatitis B virus (HBV) infection. Methods: DILI patients were enrolled and divided into a DILI group and an HBV+DILI group. Laboratory indicators were recorded and analyzed. Multivariate logistic regression and the receiver operating characteristic (ROC) curve were used to determine risk factors and the predictive value for chronic DILI. Results: Of all the 114 patients, 87 were in the DILI group and 27 were in the HBV+DILI group. Baseline total bilirubin (TBIL), direct bilirubin (DBIL), and incidence of chronicity were significantly higher in the HBV+DILI group than in the DILI group (P = 0.017, P = 0.037, P = 0.045, respectively). However, platelet (PLT) and prothrombin activity (PTA) were significantly lower in the HBV+DILI group than in the DILI group (P = 0.022, P = 0.013, respectively). HBV infection, baseline aspartate aminotransferase (AST) > 200 U/L, and TBIL > 34.2 μmol/L were predictors of chronic DILI (OR = 4.481 [95% CI, 1.298 - 15.470], P = 0.018; OR = 8.478 [95% CI, 2.079 - 34.566], P = 0.003; OR = 7.358 [95% CI, 2.215 - 24.446], P = 0.001). The area under ROC curve (AUC) of joint diagnosis for chronic DILI was 0.814 (95% CI, 0.704 - 0.925, P < 0.001), which was significantly higher than that of single parameter prediction. Also, the sensitivity, specificity, positive predictive value, and negative predictive value of joint diagnosis were 81.0%, 73.1%, 40.5%, and 94.4%, respectively. Conclusions: HBV infection aggravated liver injury. HBV infection, baseline AST > 200 U/L, and TBIL > 34.2 μmol/L were predictors of chronic DILI, and their joint diagnosis could be used to predict chronic DILI effectively.

scholarly journals Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials

2021 ◽  
Vol 164 ◽  
pp. 105404
Author(s):  
Hao Niu ◽  
Judith Sanabria-Cabrera ◽  
Ismael Alvarez-Alvarez ◽  
Mercedes Robles-Diaz ◽  
Simona Stankevičiūtė ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Liver Injury ◽  
Meta Analysis ◽  
Randomised Clinical Trials ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Therapeutic vaccination for chronic hepatitis B: A systematic review and meta‐analysis

2019 ◽  
Vol 26 (7) ◽  
pp. 803-817 ◽  
Author(s):  
Seng Gee Lim ◽  
Jennielyn Agcaoili ◽  
Nurun Nisa Amatullah De Souza ◽  
Edwin Chan
Keyword(s):  
Systematic Review ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Meta Analysis ◽  
Therapeutic Vaccination
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