scholarly journals Inflammation and C-Reactive Protein in Atrial Fibrillation: Cause or Effect?

2014 ◽  
Vol 41 (5) ◽  
pp. 461-468 ◽  
Author(s):  
Roberto Galea ◽  
Maria Teresa Cardillo ◽  
Annalisa Caroli ◽  
Maria Giulia Marini ◽  
Chiara Sonnino ◽  
...  

Atrial fibrillation is associated with substantial morbidity and mortality rates. The incompletely understood pathogenesis of this cardiac dysrhythmia makes it difficult to improve approaches to primary and secondary prevention. Evidence has accumulated in regard to a relationship between inflammation and atrial fibrillation. Investigators have correlated the dysrhythmia with myocarditis, pericardiotomy, and C-reactive protein levels, suggesting that inflammation causes atrial fibrillation or participates in its onset and continuation. Conversely, other investigators suggest that atrial fibrillation induces an inflammatory response. In this review, we summarize and critically discuss the nature and clinical role of inflammation and C-reactive protein in atrial fibrillation.

Angiology ◽  
2010 ◽  
Vol 62 (4) ◽  
pp. 310-316 ◽  
Author(s):  
Stavroula N. Psychari ◽  
Dionyssios Chatzopoulos ◽  
Efstathios K. Iliodromitis ◽  
Thomas S. Apostolou ◽  
Dimitrios T. Kremastinos

2020 ◽  
Vol 9 (7) ◽  
pp. 2315 ◽  
Author(s):  
Orianne Villard ◽  
David Morquin ◽  
Nicolas Molinari ◽  
Isabelle Raingeard ◽  
Nicolas Nagot ◽  
...  

Background. The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses the angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of the renin angiotensin aldosterone system (RAAS), as a cellular receptor to infect cells. Since the RAAS can induce and modulate pro-inflammatory responses, it could play a key role in the pathophysiology of Covid-19. Thus, we aimed to determine the levels of plasma renin and aldosterone as indicators of RAAS activation in a series of consecutively admitted patients for Covid-19 in our clinic. Methods. Plasma renin and aldosterone levels were measured, among the miscellaneous investigations needed for Covid-19 management, early after admission in our clinic. Disease severity was assessed using a seven-category ordinal scale. Primary outcome of interest was the severity of patients’ clinical courses. Results. Forty-four patients were included. At inclusion, 12 patients had mild clinical status, 25 moderate clinical status and 7 severe clinical status. In univariate analyses, aldosterone and C-reactive protein (CRP) levels at inclusion were significantly higher in patients with severe clinical course as compared to those with mild or moderate course (p < 0.01 and p = 0.03, respectively). In multivariate analyses, only aldosterone and CRP levels remained positively associated with severity. We also observed a positive significant correlation between aldosterone and CRP levels among patients with an aldosterone level greater than 102.5 pmol/L. Conclusions. Both plasmatic aldosterone and CRP levels at inclusion are associated with the clinical course of Covid-19. Our findings may open new perspectives in the understanding of the possible role of RAAS for Covid-19 outcome.


Heart Rhythm ◽  
2005 ◽  
Vol 2 (5) ◽  
pp. S120
Author(s):  
Martin Rotter ◽  
Pierre Jaïs ◽  
Christine Vergnes ◽  
Francoise Le Moigne ◽  
Yoshihide Takahashi ◽  
...  

2006 ◽  
Vol 82 (1) ◽  
pp. 97-102 ◽  
Author(s):  
Charles W. Hogue ◽  
Christopher A. Palin ◽  
Rajagopal Kailasam ◽  
Jennifer S. Lawton ◽  
Abdullah Nassief ◽  
...  

2007 ◽  
Vol 100 (10) ◽  
pp. 1552-1555 ◽  
Author(s):  
Bahar Pirat ◽  
Ilyas Atar ◽  
Cagatay Ertan ◽  
Huseyin Bozbas ◽  
Oyku Gulmez ◽  
...  

2010 ◽  
Vol 89 (3) ◽  
pp. 704-709 ◽  
Author(s):  
Ted W.O. Elenbaas ◽  
Mohamed A. Soliman Hamad ◽  
Jacques P.A.M. Schönberger ◽  
Elisabeth J. Martens ◽  
André A.J. van Zundert ◽  
...  

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