scholarly journals The effect of Borago officinalis on the signaling pathway of the NLRP3 inflammasome complex, TLR4 and some inflammatory cytokines in type II diabetic patients with acute respiratory distress syndrome

2021 ◽  
Vol 67 (3) ◽  
pp. 178-183
Author(s):  
Yanqiu Yue ◽  
Fengbin Jin ◽  
Xiaohui Yue
Keyword(s):  
Inflammatory Cytokines ◽  
Distress Syndrome ◽  
Serum Levels ◽  
Borage Oil ◽  
Diabetic Patients ◽  
Type Ii ◽  
Nlrp3 Gene ◽  
Borago Officinalis ◽  
Diabetic Type ◽  
Tlr4 Gene

Acute respiratory distress syndrome (ARDS) is a life-threatening condition in which the lungs become severely inflamed, causing the alveoli to constrict or fill with fluid, which prevents the lungs from functioning properly. This disease becomes more dangerous when it occurs in patients with diabetes. Because of the clinical condition of these patients, it is not possible to treat them with usual medicines. One of the best options for treating these people is to use herbs. Borage (Borago officinalis) is a medicinal herb that, in addition to its anti-inflammatory properties, is also able to control blood sugar. Therefore, in the current study, the effect of borage oil was considered on the signaling pathway of the NLRP3 inflammasome complex, TLR4, and serum levels of inflammatory cytokines (IL-1? and IL-18) in type II diabetic patients with ARDS. For this purpose, 25 diabetic type II patients with ARDS were divided into three groups by ARDS Berlin Definition. Then, after providing the demographic and clinical characteristics of the patients, they were treated with 30 mg/day borage oil for seven days. The expression of NLRP3 and TLR4 genes (by Real-time PCR technique) and serum levels of IL-1? and IL-18 (by ELISA test) were evaluated before and after treatment with borage oil through blood samples taken from patients. The results showed that serum levels of inflammatory cytokines (IL-1? and IL-18), NLRP3 gene, and TLR4 gene were significantly decreased in diabetic type II patients with mild ARDS by treating with borage oil. IL-1? serum level and TLR4 were significantly decreased in diabetic type II patients with moderate ARDS. But there was not any significant decrease or increase in IL-1?, IL-18, NLRP3 gene, and TLR4 gene in diabetic type II patients with severe ARDS after 7 days of treatment with borage oil. According to the obtained results, borage oil can act as a double-edged blade. Thus, in the early and middle stages of ARDS, borage oil can be effective in reducing the inflammasome pathway of inflammation and also reduce blood sugar levels in these diabetic patients. But in the severe stage of ARDS, it not only does not help to treat the ARDS; it also increases systolic and diastolic blood pressure in diabetic patients.

scholarly journals Estimation of Micronutrients (Magnesium and Iron) in Periodontitis Patients with and without Type-2 Diabetes Mellitus

2021 ◽  
Vol 10 (22) ◽  
pp. 1645-1649
Author(s):  
Pallavi Samatha Yalamanchili ◽  
Nirupa Elisetti ◽  
Janaki Kesipeddy ◽  
Bilwa Bindu A ◽  
Bhagyasree Vegunta
Keyword(s):  
Diabetes Mellitus ◽  
Statistical Significance ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Type Ii ◽  
Group I ◽  
Group 3 ◽  
Group 2

BACKGROUND The focus of this study was to assess the relationship of nutrients (magnesium, iron) in periodontitis and diabetic patients. Serum magnesium (Mg) and iron (Fe) levels were evaluated in periodontitis patients and were compared between diabetic patients with periodontitis and healthy controls. METHODS Total sixty subjects (18 females and 42 males) were recruited in this cross-sectional study and were divided into three groups - Group I (healthy subjects), Group II (chronic generalized periodontitis), Group III (Type II diabetes mellitus and chronic generalized periodontitis). Loe and Silness gingival index and probing pocket depth were used for categorizing chronic generalized periodontitis patients. Serum levels of magnesium and iron were estimated and then compared among the groups. Statistical analysis was done using one-way analysis of variance (ANOVA) and Newmann-Keuls multiple post-hoc procedures. Statistical significance was accepted for P ≤ 0.05. RESULTS Mean serum levels of magnesium (Mg) were 0.89 in Group 3 (Type II DM + CGP), 1.01 in Group 2 (CGP) against 1.52 in Group 1 (Control), which were statistically significant. Mean Iron (Fe) levels showed 165.56 in Group 3 (Type II DM + CGP), 137.77 in Group 2 (CGP) against 78.17 (Control) which is also statistically significant. CONCLUSIONS In this study, we found statistically significant decrease in magnesium and increase in serum iron levels in Group 3 (Type II DM + CGP) compared to Group 2 (CGP) and healthy controls. These findings suggest that trace elements also play an important role in the progression of periodontal disease. KEY WORDS Chronic Periodontitis, Diabetes Mellitus, Iron, Magnesium

scholarly journals ASSOCIATION OF SERUM HOMOCYSTEINE IN DIABETIC NEUROPATHY

2018 ◽  
Vol 11 ◽  
Author(s):  
Rujaswini T ◽  
Ranadheer Chowdary P ◽  
Vijey Aanandhi M ◽  
Shanmugasundaram P
Keyword(s):  
Diabetic Neuropathy ◽  
Blood Sugar ◽  
Elevated Serum ◽  
Serum Levels ◽  
Blood Parameters ◽  
P Value ◽  
Diabetic Patients ◽  
Type I ◽  
Type Ii ◽  
Serum Homocysteine

Aims and Objectives: The main aim of the study was to find out the association of serum homocysteine (HCY) in diabetic neuropathy patients. Methods: All the patients who were diagnosed with Type II diabetes mellitus will be included. Their serum levels of fasting blood sugar, postprandial blood sugar, glycated hemoglobin, and associated blood parameters will be assessed. Diabetic neuropathy will be confirmed using nerve conduction testing, electromyography, and quantitative sensory testing with clinically correlated. The serum HCY levels will be measured and correlated with other blood parameters. Results: Of 1000 patients, 46 were Type I diabetic and 954 were Type II. The prevalence of neuropathy in diabetic patients was 156. Mean serum HCY without diabetic neuropathy was 6.8+2.9 and serum HCY with diabetic neuropathy was 21.6+0.29 and p value was found to be 0.0017. The correlation between serum HCY and diabetic neuropathy was found to be 14.5 with p=0.001. Conclusion: There has been a significant increase of HCY in diabetic patients. It can be clearly seen that elevated serum HCY level has led to some of the complications of diabetic neuropathy.

scholarly journals Salivary and Serum Levels of IL-6 and IL-8 in Diabetic Patients with Periodontal Disease: A Review Article

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Fatemeh Babadi
Keyword(s):  
Diabetes Mellitus ◽  
Periodontal Disease ◽  
Type Ii Diabetes ◽  
Nonparametric Test ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Type Ii ◽  
Control Series ◽  
Significant Difference ◽  
A Minor

Context: Periodontal disease is a complication of diabetes mellitus. Both periodontal disease and diabetes mellitus stimulate the release of proinflammatory cytokines. The aim of the present study was to evaluate the salivary and serum levels of interleukin (IL-6) and IL-8 levels in type II diabetic patients with periodontal disease. Evidence Acquisition: The present study is a narrative review. A literature review was conducted using the electronic databases including Web of Science, PubMed, Scopus, Google Scholar as well as Persian databases such as SID, Magiran, and IranMedex from 2005 to 2019, particularly the last 10 years. The appropriate keywords were searched, including “Diabetes Mellitus”, “IL-6”, “IL-8”, Periodontal Disease”, “Saliva”, and “Serum”. Results: The present study analyzed four articles from the case-control series, including 42 to 90 patients. The results showed that the level of salivary concentration of IL-6 was increased in patients with periodontal disease with/without diabetes mellitus. A marginally statically significant correlation was found in salivary and serum levels of IL-6 after applying spearman’s nonparametric test. However, the relevant serum analysis showed only a minor influence of type II diabetes and periodontal disease on IL-6 serum levels. There was no significant difference between the periodontitis patients and IL-6 and IL-8 serum levels. A positive correlation was found between glycemic control and the severity of periodontal disease. Conclusions: The intensity of periodontal disease was high in patients with type II diabetes, underlining the need for special oral health care for these patients. The level of salivary IL-6 can be considered as a main biomarker in the diagnosis of diabetes and periodontal disease. The serum levels of the IL-6 and IL-8 showed no significant difference in patients with periodontitis.

scholarly journals Changes of Corneal Thickness and Intraocular Pressure in Type II Diabetic Patients

2021 ◽  
pp. 1-5
Author(s):  
Yasmena Abdulhadi
Keyword(s):  
Diabetic Retinopathy ◽  
Intraocular Pressure ◽  
Corneal Thickness ◽  
Diabetic Control ◽  
P Value ◽  
Diabetic Patients ◽  
Type Ii ◽  
Pressure Measurements ◽  
Diabetic Type ◽  
Central Cornea

Aims. The purpose of the present paper is to present the results of central corneal thickness & intraocular pressure measurements in diabetic patients with or without retinopathy, and compare the results with non-diabetic control patients. Methods. Total number was 152 patients were 152 eyes The study group was divided into 3 groups as following: 50 non diabetic (control). 50 diabetic type II with no diabetic retinopathy. 52 diabetic type II patient with diabetic retinopathy. Correlation analysis was performed to assess the association between glycosylated hemoglobin levels& Intraocular pressures and retinal changes among subgroups. Results. Demographic characteristics of study and control groups were similar (P>0.05). Mean CCT 553.62 with Std deviation (14.47) in control cases and 622.27 with Std deviation (507.09) in diabetic cases which is more than control however the distinction failed to reach applied math significance were (p value= > 0.05). additionally, CCT and diabetic retinopathy association was significant were CCT in diabetic patients with no retinal changes was 563.96 Std deviation (18.85) and in diabetic patients with retinopathy was 670.45 Std deviation (717.2) and P value = 0.004 (significant). There was significant correlation between increased corneal thickness and intraocular pressure were p-value = 0.002. Conclusions. We found that the central cornea of diabetic patients is thicker when compared with non-diabetic patients. Thicker central cornea associated with diabetes mellitus should be taken into consideration while obtaining accurate intraocular pressure measurements in diabetics.

scholarly journals Anti-arthritic effect of total anthraquinone from Polygonum cuspidatum on type II collagen-induced arthritis in rats

2017 ◽  
Vol 16 (10) ◽  
pp. 2453-2459
Author(s):  
Feng Wang ◽  
Yan-hong Qiao ◽  
Hui-min Niu ◽  
Hong Zhao
Keyword(s):  
Inflammatory Cytokines ◽  
Type Ii Collagen ◽  
Serum Levels ◽  
Underlying Mechanism ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type Ii ◽  
Polygonum Cuspidatum ◽  
Collagen Induced Arthritis ◽  
Tnf Α ◽  
Pro Inflammatory Cytokines

Purpose: To study the anti-arthritic effect of total anthraquinone from Polygonum  cuspidatum (TAPC) on type II collagen-induced arthritis (CIA) in rats, and to  investigate the underlying mechanism(s).Methods: CIA rats were prepared and treated orally with TAPC at doses of 50, 100 and 200 mg/kg/day, for 24 days. Paw volume and arthritis score were measured prior to TAPC treatment, and subsequently at 3-day intervals on days 3, 6, 9, 12, 15, 18, 21 and 24. Serum levels of TNF-α, IL-6 and IL-17 were determined by enzyme-linked immunosorbent assay (ELISA), while synovial tissue TNF-α, IL-6 and IL-17mRNA expressions were assayed by real time-polymerase chain reaction (RT-PCR). Thymus and spleen indices were also determined.Results: TAPC (50, 100 and 200 mg/kg) significantly alleviated paw swelling (p < 0.05), arthritis scores (p < 0.05) and thymus and spleen indices (p < 0.05) of CIA rats, when compared with the control rats. In addition, TAPC significantly decreased serum levels of the pro-inflammatory cytokines TNF-α, IL-6 and IL-17 (p < 0.01); and down-regulated their mRNA expressions in synovial tissues (p < 0.01).Conclusion: These results suggest that TAPC exerts good anti-arthritic activity in rats, most probably via suppression of inflammatory responses.Keywords: Polygonum cuspidatum, Anthraquinone, Type II collagen-induced  arthritis, Pro-inflammatory cytokines

scholarly journals Homocysteine Serum Levels in Diabetic Patients with Non Proliferative, Proliferative and without Retinopathy

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Giulia Malaguarnera ◽  
Caterina Gagliano ◽  
Maria Giordano ◽  
Salvatore Salomone ◽  
Marco Vacante ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Healthy Subjects ◽  
Vision Loss ◽  
Serum Levels ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetic Type ◽  
Working Adults

Homocysteine has been associated with extracellular matrix changes. The diabetic retinopathy is a neurovascular complication of diabetes mellitus and it is the leading cause of vision loss among working adults worldwide. In this study, we evaluate the role of homocysteine in diabetic retinopathy analyzing the plasma levels of homocysteine in 63 diabetic type 2 patients with nonproliferative retinopathy (NPDR), 62 patients with proliferative diabetic retinopathy (PDR), 50 healthy subjects used as control group, and 75 randomly selected patients.

scholarly journals Evaluation of serum levels of homocysteine, C-peptide and lipid profile in type I and type II diabetic patients in Hawler province/Iraq

2013 ◽  
Vol 17 (2) ◽  
pp. 400-404
Author(s):  
Abdulrahman Mohammed ◽  
Abdulkader Alnakshabandi ◽  
Abdulrahman Al-Bazzaz
Keyword(s):  
Lipid Profile ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Type I ◽  
Type Ii ◽  
C Peptide
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