scholarly journals Study of the antimicrobial and fungicidal activity of thiotriazoline and decamethoxinum as a potentially new model mixture for use of the oral mucosa

Author(s):  
L. I. Kucherenko ◽  
I. F. Bielenichev ◽  
O. О. Chonka ◽  
Z. B. Moriak ◽  
O. O. Portna
2021 ◽  
pp. 70-76
Author(s):  
R. V. Ushakov ◽  
V. N. Tsarev ◽  
Т. V. Ushakova ◽  
Т. V. Tsareva ◽  
A. R. Ushakov ◽  
...  

Candidiasis is the most common mycosis. Оral candidiasis occurs in the form of stomatitis, including the so-called prosthetic stomatitis. Somewhat less often, fungi of the genus Candida are detected with gingivitis and periodontitis, manifestations of red lichen planus on the oral mucosa.The purpose of the work: to analyze the results of mycological studies and determine the sensitivity of fungi isolated from the oral cavity in vari-ous oral pathologies to the main antimycotics, as well as the formation on this basis of an algorithm for antimycotic therapy of candidal lesions of the oral mucosa and periodontium.Material and methods. The paper uses the results of studies of patients with candidiasis of the oral mucosa (127 patients), prosthetic stomatitis (136 patients), candida-associated periodontitis (168 patients). Primary inoculation was performed quantitatively on Sabouraud’s medium and duplicated on M1297 chromogenic medium (Himedia Labs, India).To study the biofilm formed on the oral mucosa, fixed preparations of gold-coated scrapings were prepared for scanning electron microscopy, which was performed using a Quanta 200 3D bi-beam microscope (USA). Sensitivity to antimycotics was assessed using the traditional method of disks.The results of the study. When studying the species composition of yeast-like fungi isolated from the material, it was found that the species C. albicans was isolated in 80% of patients, in association with other species: C. Krusei, C. guilliermondii and C. glabrata. The second place was taken by the species C. Krusei, which was detected in 13.3% of patients. Representatives of this genus of yeast fungi are characterized by the formation of a biofilm with a pronounced mantle, which protects the microorganism from aggressive factors, including antimycotics and antiseptics. All the studied preparations showed fungicidal activity against these strains of yeast-like fungi. When registering the results, it was found that the most pronounced sensitivity of yeast-like fungi of this species was to drugs from the group of azole derivatives. The most pronounced antifungal activity was noted by us in voriconazole.Conclusion. Based on the obtained data, an algorithm of systemic antimycotic therapy for oral candidiasis has been developed.


Author(s):  
H. Akabori ◽  
K. Nishiwaki ◽  
K. Yoneta

By improving the predecessor Model HS- 7 electron microscope for the purpose of easier operation, we have recently completed new Model HS-8 electron microscope featuring higher performance and ease of operation.


Author(s):  
E. J. Kollar

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.


2005 ◽  
Vol 173 (4S) ◽  
pp. 140-141
Author(s):  
Mariana Lima ◽  
Celso D. Ramos ◽  
Sérgio Q. Brunetto ◽  
Marcelo Lopes de Lima ◽  
Carla R.M. Sansana ◽  
...  

1979 ◽  
Vol 12 (1) ◽  
pp. 15-20 ◽  
Author(s):  
William K. Bottomley
Keyword(s):  

Author(s):  
Thorsten Meiser

Stochastic dependence among cognitive processes can be modeled in different ways, and the family of multinomial processing tree models provides a flexible framework for analyzing stochastic dependence among discrete cognitive states. This article presents a multinomial model of multidimensional source recognition that specifies stochastic dependence by a parameter for the joint retrieval of multiple source attributes together with parameters for stochastically independent retrieval. The new model is equivalent to a previous multinomial model of multidimensional source memory for a subset of the parameter space. An empirical application illustrates the advantages of the new multinomial model of joint source recognition. The new model allows for a direct comparison of joint source retrieval across conditions, it avoids statistical problems due to inflated confidence intervals and does not imply a conceptual imbalance between source dimensions. Model selection criteria that take model complexity into account corroborate the new model of joint source recognition.


1986 ◽  
Vol 31 (2) ◽  
pp. 108-109
Author(s):  
Alexandra G. Kaplan
Keyword(s):  

PsycCRITIQUES ◽  
2004 ◽  
Vol 49 (Supplement 13) ◽  
Author(s):  
Paul E. Priester
Keyword(s):  

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