This paper presents an efficient approach to diesel engine combustion simulation that integrates detailed chemical kinetics into a quasidimensional fuel spray model. The model combines a discrete spray parcel concept to calculate fuel-air mixing with a detailed primary reference fuel chemical kinetic mechanism to determine species concentrations and heat release in time. Comparison of predicted pressure, heat release, and emissions with data from diesel engine experiments reported in the literature shows good agreement overall, and suggests that spray combustion processes can be predictively modeled without calibration of empirical burn rate constants at a significantly lower computational cost than standard multidimensional (CFD) tools.