scholarly journals Impact of clopidogrel on postoperative blood loss after non-elective coronary bypass surgery

2005 ◽  
Vol 4 (6) ◽  
pp. 546-549 ◽  
Author(s):  
F. Nurozler
Keyword(s):  
Blood Loss ◽  
Bypass Surgery ◽  
Coronary Bypass ◽  
Coronary Bypass Surgery ◽  
Postoperative Blood Loss

Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery

Perfusion ◽  
2000 ◽  
Vol 15 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Sergio V Moran ◽  
Guillermo Lema ◽  
Jessica Medel ◽  
Manuel J Irarrazaval ◽  
Ricardo Zalaquett ◽  
...  
Keyword(s):  
Blood Loss ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Coronary Bypass ◽  
Drug Efficacy ◽  
Coronary Bypass Surgery ◽  
Postoperative Blood Loss ◽  
Treatment Groups ◽  
Group I ◽  
Transfusion Requirements

This study was designed to evaluate efficacy and tolerability of two different doses of aprotinin in patients receiving aspirin before undergoing coronary artery bypass grafting. Forty-two patients were randomized to receive either placebo (group I), or aprotinin in doses of 4 000 000 KIU (group II) or 6 000 000 KIU (group III). Drug efficacy was determined by measuring postoperative blood loss and transfusion of blood products. Both doses were effective in reducing blood loss and transfusion requirements. Blood loss through thoracotomy drainage was 450 ± 224, 182 ± 144, 142 ± 98 ml, respectively, for control and treatment groups II and III ( p = 0.0001). The numbers of patients with blood transfusions were seven (50%), two (17%) and two (17%) for group I and treatment groups II and III, respectively ( p = 0.10). Tolerability was excellent and complications few and reversible. In conclusion, high and medium doses of aprotinin were well tolerated and reduced bleeding and transfusion requirements in patients submitted to coronary bypass surgery under the effects of aspirin.

Early Activation of Hemostasis during Cardiopulmonary Bypass: Evidence for Thrombin Mediated Hyperfibrinolysis

1992 ◽  
Vol 68 (03) ◽  
pp. 250-252 ◽  
Author(s):  
H Teufelsbauer ◽  
Sylvia Proidl ◽  
M Havel ◽  
Th Vukovich
Keyword(s):  
Cardiopulmonary Bypass ◽  
Blood Loss ◽  
Time Course ◽  
Bypass Surgery ◽  
Antithrombin Iii ◽  
Degradation Products ◽  
Coronary Bypass ◽  
Postoperative Blood Loss ◽  
Fibrin Degradation Products ◽  
Coagulation And Fibrinolysis

SummaryIn 14 consecutive patients undergoing cardiopulmonary bypass for coronary bypass surgery the time course of coagulation and fibrinolysis markers were measured, e.g. plasma levels of thrombin-antithrombin III (TAT) complexes, cross-linked fibrin degradation products (X1FDP) and plasmin-α2-antiplasmin complexes (PAP). TAT levels exceeded the 90% baseline percentile already during CPB (after opening of aortic clamp) in 10 patients, whereas PAP and X1FDP exceeded their 90% percentile in only one patient at this time. Concerning fibrinolysis markers PAP and X1FDP the majority of patients showed elevations higher than their 90% baseline percentile only 1 h postoperation. Correlation analysis revealed significant dependencies between TAT levels during and at the end of CPB and PAP levels 1 h postoperation (R = 0.55 and R = 0.56 respectively). Furthermore, 1 h postoperation X1FDP levels were significantly correlated with both TAT and PAP. Peak X1FDP levels at the same time correlated with blood loss via thoracic drains (R = 0.56). Thus, we suggest that hyperfibrinolysis in patients undergoing CPB is at least partly due to hypercoagulation. Clinically, this may implicate that intensified anticoagulation could prevent hyperfibrinolysis and reduce postoperative blood loss.

Blood Loss and Bank Blood Requirement in Coronary Bypass Surgery

1978 ◽  
Vol 26 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Thomas Yeh ◽  
Larry Shelton ◽  
Thomas J. Yeh
Keyword(s):  
Blood Loss ◽  
Bypass Surgery ◽  
Coronary Bypass ◽  
Coronary Bypass Surgery ◽  
Bank Blood

Facilitated vascular anastomosis in coronary bypass surgery

2002 ◽  
Vol 14 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Valavanur A. Subramanian ◽  
James D. Fonger ◽  
Mark W. Connolly
Keyword(s):  
Bypass Surgery ◽  
Coronary Bypass ◽  
Coronary Bypass Surgery ◽  
Vascular Anastomosis

Gender differences in secretion of adipokines off pump coronary bypass surgery (OPCAB)

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
H Loeblein ◽  
O Dzemali ◽  
K Graves ◽  
A Kostorz ◽  
C Meier ◽  
...  
Keyword(s):  
Gender Differences ◽  
Bypass Surgery ◽  
Coronary Bypass ◽  
Coronary Bypass Surgery ◽  
Off Pump
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