scholarly journals The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss

2020 ◽  
Vol 15 (1) ◽  
pp. 884-889
Author(s):  
İbrahim Özcan ◽  
İbrahim Hira ◽  
Altan Kaya ◽  
Mehmet Yaşar ◽  
Murat Doğan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Predictive Value ◽  
Study Groups ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Microvascular Damage ◽  
Distribution Width ◽  
Group 1

AbstractBackgroundWe aimed to evaluate the association between mean platelet volume, platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT), and the presence of sudden sensorineural hearing loss (SSNHL) and treatment response. In the literature, there is no study that investigates the platelet functions in diabetic patients with SSNHL.MethodsThe patients were retrospectively assigned into Group 1 (68 diabetic patients with SSNHL), Group 2 (63 nondiabetic patients with SSNHL) and Group 3 (64 healthy controls).ResultsPC was not significantly different between the groups (p > 0.05). MPV, PDW and PCT values were significantly higher in Group 1 as compared to Groups 2 and 3 (p < 0.05). Platelet parameters were not significantly different between the patients who were responsive and nonresponsive to the treatment. Therefore, the platelet parameters did not affect prognosis significantly in this study samples (p > 0.05).ConclusionsThis study showed that platelet parameters did not have a significant effect as a prognostic and predictive value in diabetic and nondiabetic patients with SSNHL. Further studies with more homogenous and larger study groups investigating the platelet parameters are needed to demonstrate microvascular damage and vascular alterations induced by diabetes mellitus.

Framingham risk score is associated with hearing outcomes in patients with idiopathic sudden sensorineural hearing loss

2020 ◽  
Vol 134 (5) ◽  
pp. 419-423
Author(s):  
Y-S Chang ◽  
S Park ◽  
M K Lee ◽  
Y C Rah ◽  
J Choi
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Risk Score ◽  
Pure Tone ◽  
Framingham Risk Score ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Pure Tone Average ◽  
Framingham Risk ◽  
Group 1

AbstractObjectiveTo assess the Framingham risk score as a prognostic tool for idiopathic sudden sensorineural hearing loss patients.MethodsMedical records were reviewed for unilateral idiopathic sudden sensorineural hearing loss patients between January 2010 and October 2017. The 10-year risk of developing cardiovascular disease was calculated. Patients were subdivided into groups: group 1 – Framingham risk score of less than 10 per cent (n = 28); group 2 – score of 10 to less than 20 per cent (n = 6); and group 3 – score of 20 per cent or higher (n = 5).ResultsInitial pure tone average and Framingham risk score were not significantly associated (p = 0.32). Thirteen patients in group 1 recovered completely (46.4 per cent), but none in groups 2 and 3 showed complete recovery. Initial pure tone average and Framingham risk score were significantly associated in multivariable linear regression analysis (R2 = 0.36). The regression coefficient was 0.33 (p = 0.003) for initial pure tone average and −0.67 (p = 0.005) for Framingham risk score.ConclusionFramingham risk score may be useful in predicting outcomes for idiopathic sudden sensorineural hearing loss patients, as those with a higher score showed poorer hearing recovery.

Clinical Features of Sudden Sensorineural Hearing Loss in Diabetic Patients

2005 ◽  
Vol 115 (9) ◽  
pp. 1676-1680 ◽  
Author(s):  
Shuen-Fu Weng ◽  
Yuh-Shyang Chen ◽  
Chuan-Jen Hsu ◽  
Fen-Yu Tseng
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Clinical Features ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients

Prognostic Factors of Sudden Sensorineural Hearing Loss in Diabetic Patients

Diabetes Care ◽  
2004 ◽  
Vol 27 (10) ◽  
pp. 2560-2561 ◽  
Author(s):  
S.-F. Weng ◽  
Y.-S. Chen ◽  
T.-C. Liu ◽  
C.-J. Hsu ◽  
F.-Y. Tseng
Keyword(s):  
Hearing Loss ◽  
Prognostic Factors ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients

Risk of Developing Sudden Sensorineural Hearing Loss in Diabetic Patients

2012 ◽  
Vol 33 (9) ◽  
pp. 1482-1488 ◽  
Author(s):  
Shih-Wei Lin ◽  
Yung-Song Lin ◽  
Shih-Feng Weng ◽  
Chien-Wen Chou
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients

scholarly journals Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Shuaifei Ji ◽  
Xuemin Chen ◽  
Heng Shi ◽  
Babo Zhang ◽  
Shun Yao ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Meta Analysis ◽  
Geographical Area ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Distribution Width ◽  
Eastern Country ◽  
Standard Mean Difference ◽  
Significant Difference

Recent years, the discussion about whether platelets participant in the development of sudden sensorineural hearing loss (SSHL) continues and many studies on the relationship between them have come to our attention. Some studies believe that platelet parameters have significantly changed in patients with SSHL, while some not, controversially. Therefore, to investigate the association between platelet parameters, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PLT), and SSHL, expecting to resolve controversy and provide clinical evidence for diagnosis and monitoring of SSHL. Basic methods: Literature was retrieved searching electronic databases (PubMed, Embase, Cochrane, and Scopus) and searching references of related articles by hand. A total of 18 case–control studies involving 1837/1734 subjects (SSHL/control) were included. Meta-analysis showed there was no difference between the patients who suffered SSHL and healthy controls in MPV level [standard mean difference (SMD) (95% confidence interval (CI)) = 0.16 (−0.07, 0.40), I2 = 80%, P<0.00001] and PLT [SMD (95% CI) = −0.03(−0.18, 0.12), I2 = 73%, P<0.00001]. While PDW exhibited significant difference [SMD (95% CI) = 0.85 (0.20, 1.49), I2 = 93%, P<0.00001]. Subgroup analysis about geographical area suggested PLT have obvious evidence for SSHL in Eastern country [SMD (95% CI) = 0.23 (0.14, 0.33), I2 = 0%, P=0.81]. Our study did not support a correlation between MPV and SSHL, while PLT may have clinical significance for SSHL in Eastern country. With insufficient data to explore the resource of heterogeneity for PDW, there is no decisive conclusion reached.

Red blood cell distribution width predicts prognosis in idiopathic sudden sensorineural hearing loss

2016 ◽  
Vol 136 (11) ◽  
pp. 1137-1140 ◽  
Author(s):  
Hiroshi Nonoyama ◽  
Tohru Tanigawa ◽  
Rei Shibata ◽  
Yoshio Nakao ◽  
Yuichiro Horibe ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Blood Cell ◽  
Sensorineural Hearing Loss ◽  
Red Blood Cell ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Effect of Diabetes on the Prognosis of Sudden Sensorineural Hearing Loss: Propensity Score Matching Analysis

2020 ◽  
Vol 162 (3) ◽  
pp. 346-352 ◽  
Author(s):  
Hee Won Seo ◽  
Jae Ho Chung ◽  
Hayoung Byun ◽  
Jin-Hyeok Jeong ◽  
Seung Hwan Lee
Keyword(s):  
Hearing Loss ◽  
Propensity Score ◽  
Sensorineural Hearing Loss ◽  
Propensity Score Matching ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Hearing Level ◽  
Treatment Results ◽  
Similar Treatment

Objective The aim of this study was to investigate the clinical implications of diabetes for the management of idiopathic sudden sensorineural hearing loss (ISSNHL). Study Design Retrospective study. Setting Tertiary referral center. Subjects and Methods ISSNHL patients (N = 403) who received inpatient management between January 2015 and December 2018 were analyzed. All were managed by a uniform treatment protocol of high-dose steroid therapy and salvage intratympanic steroid injections. Treatment results were evaluated according to the American Academy of Otolaryngology—Head and Neck Surgery’s criteria 3 months after the start of treatment. We compared the clinical parameters and treatment outcomes of ISSNHL with and without diabetes. We also evaluated the influence of diabetes on the prognosis of ISSNHL by propensity score matching. Results Overall, of the 403 ISSNHL patients, 94 (23.3%) had diabetes, and 11 were newly diagnosed with diabetes. The patients with diabetes were older than those without diabetes ( P < .001), and their initial hearing threshold was significantly higher ( P < .001). The diabetic patients were hospitalized for a longer period, and their hearing recovery rate was lower. However, when age, sex, and initial hearing level were adjusted by propensity score matching, the diabetic patients and matched controls yielded similar treatment results. Conclusions ISSNHL with diabetes usually presents with severe hearing loss and requires longer hospitalization. However, diabetes itself may not influence the prognosis of ISSNHL. Proper management must be provided in ISSNHL with diabetes.

scholarly journals Association of Glycosylated Hemoglobin A1c Level With Sudden Sensorineural Hearing Loss: A Prospective Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Ying Shen ◽  
Zhong Zheng ◽  
Lili Xiao ◽  
Chengqi Liu ◽  
Jingyi Guo ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Hba1c Level ◽  
Hemoglobin A1c ◽  
Glycosylated Hemoglobin ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Glycosylated Hemoglobin A1c ◽  
A Prospective Study

Glycosylated hemoglobin A1c (HbA1c) level has strong relevance to microvascular disorders, which are also thought to be the current main aspect of sudden sensorineural hearing loss (SSNHL), so we aim to elucidate the association of the HbA1c level with the severity, types, and prognosis of SSNHL. In this study, comparative analyses based on propensity score matching of the severity, types, and prognosis of SSNHL with the HbA1c level in 116 patients diagnosed as SSNHL were conducted, where they were divided into diabetes mellitus (DM) group and non-DM group. We finally found that, among patients with SSNHL, diabetic patients had a higher HbA1c level, more severe hearing loss, and poorer prognosis than non-diabetic patients. The HbA1c level was found to be significantly correlated with the severity and types of SSNHL, while no strong relevance was found between the higher HbA1c level and the poorer prognosis of SSNHL.

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