A native steroid hormone derivative triggers the resolution of inflammation
2010 ◽
Vol 1
(1)
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Keyword(s):
Tnf Α
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AbstractInflamed tissues produce both prostaglandins (PGs) and 7α-hydroxylated derivatives of native circulating 3β-hydroxysteroids. These 7α-hydroxysteroids are in turn transformed into 7β-hydroxylated epimers by 11β-hydroxysteroid dehydrogenase type 1 in the tissue. 7β-Hydroxy-epiandrosterone (7β-hydroxy-EpiA) affects PG production in two models of inflammation, dextran sodium sulfate-induced colitis in the rat and TNF-α-induced activation of PG production and PG synthase expression in cultured human peripheral blood monocytes (hPBMC). Treatment with 7β-hydroxy-EpiA led to a shift from high to low colonic PGE
Keyword(s):
2001 ◽
Vol 109
(06)
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pp. 340-344
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Keyword(s):
2003 ◽
Vol 95
(2)
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pp. 192-195
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Keyword(s):
2003 ◽
Vol 40
(5)
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pp. 534-541
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Keyword(s):
1989 ◽
Vol 121
(1)
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pp. 75-84
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1996 ◽
Vol 18
(1)
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pp. 37-44
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