Über die Bildung von Wasserstoffperoxyd bei der Hemmung der Glykolyse von Ascites-Tumorzellen durch Phenanthrenchinon

1961 ◽  
Vol 16 (2) ◽  
pp. 120-126 ◽  
Author(s):  
Heinz Tiedemann ◽  
Hans-Jörg Risse
Keyword(s):  
Tumor Cell ◽  
Cell Suspension ◽  
Tumor Cells ◽  
Respiratory Chain ◽  
Kidney Cell ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Autoxidation Reaction ◽  
Stimulation Of

Under aerobic conditions hydrogenperoxide is formed in a glycolyzing suspension of Ehrlich-Ascites tumor cells after incubation with phenanthraquinone(9.10). Not glycolyzing tumor cells and also a kidney cell suspension produce very little hydrogenperoxide only.In glycolyzing tumor cells phenanthraquinone(9.10) is reduced rapidly to the corresponding hydroquinone. During the autoxidation of the hydroquinone hydrogenperoxide is formed. A great stimulation of O2-uptake is related with the autoxidation reaction. This stimulation also appears after blocking the respiratory chain by cyanide.The inhibition of tumor cell glycolysis is caused by an inhibition of glycerinaldehydphosphatdehydrogenase and a decrease of the DPN level.

Heterotransplantation of Ehrlich Ascites Tumor Cells in Rats Pre-Treated with Cytostatics and Antimetabolites

1970 ◽  
Vol 25 (10) ◽  
pp. 1175-1179 ◽  
Author(s):  
Emanuil Emanuilov ◽  
Evgeny Golovinsky
Keyword(s):  
Tumor Growth ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Dose Dependence ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Tumor Cell Population ◽  
Ehrlich Ascites ◽  
Progressive Growth

Pre-reatment of rats with various doses of cytostatics and antimetabolites (cyclophosphamide, mitomycin-C, 6-mercaptopurine, 6-azauridine and 5-azaorotic acid) permits successful heterotransplantation of Ehrlich ascites tumor, as indicated by the progressive growth of the tumor cell population. Experiments with cyclophosphamide suggest a direct dose dependence of the rate of tumor growth in heterologous recipients.

scholarly journals STUDIES WITH THE ELECTRON MICROSCOPE OF VIRUS-HOST RELATIONSHIPS IN EHRLICH ASCITES TUMOR CELLS

1955 ◽  
Vol 102 (4) ◽  
pp. 371-378 ◽  
Author(s):  
Marlene Friedlaender ◽  
Dan H. Moore ◽  
Hilary Koprowski
Keyword(s):  
Endoplasmic Reticulum ◽  
Electron Microscope ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Ehrlich Ascites Tumor Cell ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Host Relationships

Evidence is presented suggesting that anopheles A virus in the Ehrlich ascites tumor cell is harbored and propagated within the endoplasmic reticulum which in this system consists of an extensive canalicular network. The organization and differentiation of endoplasmic reticulum within the cell are described and the significance of such a location of virus is discussed.

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