scholarly journals Role of Projections from Ventral Medial Prefrontal Cortex to Nucleus Accumbens Shell in Context-Induced Reinstatement of Heroin Seeking

2012 ◽  
Vol 32 (14) ◽  
pp. 4982-4991 ◽  
Author(s):  
J. M. Bossert ◽  
A. L. Stern ◽  
F. R. M. Theberge ◽  
N. J. Marchant ◽  
H.-L. Wang ◽  
...  
2005 ◽  
Vol 17 (5) ◽  
pp. 832-846 ◽  
Author(s):  
David M. Schnyer ◽  
Lindsay Nicholls ◽  
Mieke Verfaellie

Making judgments about the retrievability of information is a critical part of the metamemory processes engaged during remembering. A recent study of patients with frontal lesions suggests that ventral medial prefrontal cortex (VMPC) plays a critical role in such judgments [Schnyer, D. M., Verfaellie, M., Alexander, M. P., Lafleche, G., Nicholls, L., & Kaszniak, A. W. A role for right medial prefrontal cortex in accurate feeling of knowing judgments: Evidence from patients with lesions to frontal cortex. Neuropsychologia, 42, 957–966, 2004]. The observed impairment was thought to reflect an inability to determine the accessibility of memory contents. To further examine the neuroanatomical basis of content accessibility assessment, we used fMRI in an episodic feeling-of-knowing (FOK) paradigm. Participants were asked to make trial-by-trial predictions about the retrievability of the final word that completed studied sentences and then to select the correct completion from among alternatives. Results indicated that the VMPC is engaged during accurate FOK judgments and its activation is modulated by retrieval rating. Structural equations modeling supported the notion that VMPC, as part of a broader left hemisphere network involved in memory retrieval, monitors the output of the retrieval process. More generally, VMPC may participate in metacognitive processes that allow for the comparison of available data against an internal model.


2009 ◽  
Vol 56 ◽  
pp. 177-185 ◽  
Author(s):  
Eisuke Koya ◽  
Jamie L. Uejima ◽  
Kristina A. Wihbey ◽  
Jennifer M. Bossert ◽  
Bruce T. Hope ◽  
...  

2010 ◽  
Vol 48 (12) ◽  
pp. 3505-3512 ◽  
Author(s):  
Murray Grossman ◽  
Paul J. Eslinger ◽  
Vanessa Troiani ◽  
Chivon Anderson ◽  
Brian Avants ◽  
...  

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