scholarly journals Rapid Signaling of Estrogen in Hypothalamic Neurons Involves a Novel G-Protein-Coupled Estrogen Receptor that Activates Protein Kinase C

2003 ◽  
Vol 23 (29) ◽  
pp. 9529-9540 ◽  
Author(s):  
Jian Qiu ◽  
Martha A. Bosch ◽  
Sandra C. Tobias ◽  
David K. Grandy ◽  
Thomas S. Scanlan ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
G Protein ◽  
Hypothalamic Neurons ◽  
Kinase C ◽  
Rapid Signaling ◽  
G Protein Coupled

Involvement of gamma protein kinase C in estrogen-induced neuroprotection against focal brain ischemia through G protein-coupled estrogen receptor

2005 ◽  
Vol 93 (4) ◽  
pp. 883-891 ◽  
Author(s):  
Shigeto Hayashi ◽  
Takehiko Ueyama ◽  
Taketoshi Kajimoto ◽  
Keiko Yagi ◽  
Eiji Kohmura ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
G Protein ◽  
Brain Ischemia ◽  
Kinase C ◽  
G Protein Coupled ◽  
Focal Brain Ischemia

scholarly journals Modulation of human erg K+channel gating by activation of a G protein-coupled receptor and protein kinase C

1998 ◽  
Vol 511 (2) ◽  
pp. 333-346 ◽  
Author(s):  
Francisco Barros ◽  
David Gómez-Varela ◽  
Cristina G. Viloria ◽  
Teresa Palomero ◽  
Teresa Giráldez ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
G Protein ◽  
Channel Gating ◽  
K Channel ◽  
G Protein Coupled Receptor ◽  
Kinase C ◽  
G Protein Coupled

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors

10.1038/7243 ◽  
1999 ◽  
Vol 2 (4) ◽  
pp. 331-338 ◽  
Author(s):  
W-Y. Lu ◽  
Z-G. Xiong ◽  
S. Lei ◽  
B. A. Orser ◽  
E. Dudek ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nmda Receptors ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Kinase C ◽  
G Protein Coupled

scholarly journals Dual Requirement for Rho and Protein Kinase C in Direct Activation of Phospholipase D1 Through G Protein-coupled Receptor Signaling

2000 ◽  
Vol 11 (12) ◽  
pp. 4359-4368 ◽  
Author(s):  
Guangwei Du ◽  
Yelena M. Altshuller ◽  
Yong Kim ◽  
Jung Min Han ◽  
Sung Ho Ryu ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
G Protein ◽  
Receptor Activation ◽  
Fiber Formation ◽  
Actin Stress Fiber ◽  
Kinase C ◽  
Phospholipase D1 ◽  
G Protein Coupled

G protein-coupled and tyrosine kinase receptor activation of phospholipase D1 (PLD1) play key roles in agonist-stimulated cellular responses such as regulated exocytosis, actin stress fiber formation, and alterations in cell morphology and motility. Protein Kinase C, ADP-ribosylation factor (ARF), and Rho family members activate PLD1 in vitro; however, the actions of the stimulators on PLD1 in vivo have been proposed to take place through indirect pathways. We have used the yeast split-hybrid system to generate PLD1 alleles that fail to bind to or to be activated by RhoA but that retain wild-type responses to ARF and PKC. These alleles then were employed in combination with alleles unresponsive to PKC or to both stimulators to examine the activation of PLD1 by G protein-coupled receptors. Our results demonstrate that direct stimulation of PLD1 in vivo by RhoA (and by PKC) is critical for significant PLD1 activation but that PLD1 subcellular localization and regulated phosphorylation occur independently of these stimulatory pathways.

Sign in / Sign up

Export Citation Format

Share Document