SERUM SOMATOMEDIN ACTIVITY MEASURED AS SULPHATION FACTOR IN PERIPHERAL, HEPATIC AND RENAL VEINS OF PATIENTS WITH ALCOHOLIC CIRRHOSIS

1978 ◽  
Vol 88 (4) ◽  
pp. 729-736 ◽  
Author(s):  
R. M. Schimpff ◽  
D. Lebrec ◽  
M. Donnadieu ◽  
A. M. Repellin
Keyword(s):  
Growth Hormone ◽  
Chick Embryo ◽  
Hepatic Vein ◽  
Peripheral Blood ◽  
Renal Vein ◽  
Alcoholic Hepatitis ◽  
Alcoholic Cirrhosis ◽  
Peripheral Vein ◽  
Renal Veins ◽  
Serum Samples

ABSTRACT Serum somatomedin (SM) activity, measured as sulphation factor on chick embryo cartilage, and growth hormone (GH) levels were measured in peripheral, hepatic and renal veins of 23 patients with alcoholic cirrhosis. SM activity (mean ± sem) was 0.65 ± 0.05 U/ml in peripheral vein, 0.59 ± 0.04 U/ml in hepatic vein, and 0.74 ± 0.07 U/ml in renal vein. Mean GH levels were respectively 2.8, 2.5 and 3.1 ng/ml. Compared to peripheral vein, SM increase in renal vein was 19% (P < 0.05). Serum SM activity was significantly lower in 13 patients with alcoholic hepatitis associated with cirrhosis than in other 10 patients (P < 0.02 in hepatic blood and P < 0.05 in peripheral blood). The decrease of SM activity seems related to cytolysis and hepato-cellular insufficiency. At last, in patients with alcoholic hepatitis, SM activity was lower in the hepatic vein than in the peripheral vein (P < 0.05). The cause of this difference remains under discussion, no SM inhibitors being found in the serum samples used in this study.

Serum somatomedin activity measured as sulphation factor in peripheral, hepatic and renal veins of mongrel dogs: basal levels

1980 ◽  
Vol 93 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Rose-Marie Schimpff ◽  
Marcel Donnadieu ◽  
Michel Duval ◽  
Brigitte Leduc
Keyword(s):  
Chick Embryo ◽  
Negative Correlation ◽  
Peripheral Blood ◽  
Renal Vein ◽  
Hepatic Veins ◽  
Peripheral Vein ◽  
Renal Veins ◽  
Production Site

Abstract. Serum somatomedin (SM) activity measured as sulphation factor on chick embryo cartilage was determined in peripheral (PV), hepatic (HV) and renal (RV) veins or 36 mongrel dogs. Mean SM activity ± sem was 0.53 ± 0.03 U/ml in peripheral and hepatic veins, and 0.61 ± 0.04 U/ml in renal vein (P<0.005). When the gradient of SM activity in hepatic or renal vein to that in peripheral vein, [HV]-[PV] or [HV]-[PV], was plotted versus SM activity in peripheral blood [PV], a negative correlation was found in the case of hepatic but not of renal blood. These data indicate that the kidney may be a production site of SM activity, whereas the liver is differently implicated in the overall regulation of SM activity.

THE LIVER AS A SOURCE OF SOMATOMEDIN

1976 ◽  
Vol 83 (2) ◽  
pp. 365-372 ◽  
Author(s):  
R. M. Schimpff ◽  
M. Donnadieu ◽  
J. C. Glasinovic ◽  
J. M. Warnet ◽  
F. Girard
Keyword(s):  
Chick Embryo ◽  
Portal Vein ◽  
Hepatic Vein ◽  
Femoral Vein ◽  
The Other ◽  
Peripheral Vein ◽  
Serum Samples ◽  
S Uptake ◽  
The Difference ◽  
Portal Veins

ABSTRACT Somatomedin (Sm) activity (measured by [35S] uptake in chick embryo cartilage) was determined in serum samples simultaneously drawn from the hepatic vein, portal vein, femoral artery and femoral vein of seventeen anaesthezied normal adult dogs). A pool of human serum was taken as reference (Sm = 1 U/ml). Sm levels in the peripheral vein of dogs were 0.38 ± 0.03 U/ml). Mean ± sem). Sm activity was greater in the hepatic vein (0.48 U/ml) than in the other vessels (0.36, 0.39, 0.38 U/ml), and the paired differences were significant (P<0.02 to P<0.05). In three dogs which received b-GH (20 IU/day), the Sm levels were significantly increased after nine days in the femoral vein (P < 0.05) and in the hepatic vein (P < 0.05). The validity of the assay is discussed; a possible interference of NEFA in the assay is eliminated. The difference of Sm levels between hepatic and portal veins, related to hepatic flow measured in seven of these dogs, indicate an important production of Sm by the liver.

METABOLIC FATE OF HUMAN CALCITONIN IN THE DOG

1974 ◽  
Vol 61 (2) ◽  
pp. 199-210 ◽  
Author(s):  
MARY B. CLARK ◽  
CLAIR C. WILLIAMS ◽  
BRENDA M. NATHANSON ◽  
RIMA E. HORTON ◽  
H. I. GLASS ◽  
...  
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Blood Volume ◽  
Hepatic Vein ◽  
Renal Vein ◽  
Human Calcitonin ◽  
Plasma Samples ◽  
Metabolic Fate ◽  
Renal Veins

SUMMARY The metabolism of human calcitonin by the liver and kidneys was studied in dogs. Hormone was infused into anaesthetized animals and plasma samples for radioimmunoassay collected from catheters placed in the aorta, hepatic and renal veins. Compared with arterial levels, 30·1 ± 3·3 (S.E.M.)% less hormone was measured in renal vein samples and 8·3 ± 3·0% less in hepatic vein samples. From estimates of blood volume and renal blood flow, it was calculated that the kidneys removed 8% of the circulating hormone/min. Further studies demonstrated that (i) removal of the kidneys prolonged the disappearance of the hormone, (ii) less than 0·3% of infused stable hormone appeared in urine, (iii) radioactivity in kidneys of dogs infused with 131I-labelled calcitonin was concentrated in the cortex, (iv) this uptake of radioactivity was decreased by prior perfusion with stable hormone, and (v) unlabelled hormone disappeared when incubated with homogenates of kidney. From these findings, it is concluded that the kidney plays the major role in the clearance of human calcitonin from the blood and that this clearance is due probably to enzymic degradation.

scholarly journals Determinants of Erythrocyte Size in Chronic Liver Disease

Blood ◽  
1969 ◽  
Vol 34 (6) ◽  
pp. 739-746 ◽  
Author(s):  
THOMAS M. KILBRIDGE ◽  
PAUL HELLER
Keyword(s):  
Bone Marrow ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Peripheral Blood ◽  
Hepatic Cirrhosis ◽  
Alcoholic Cirrhosis ◽  
Clinical Findings ◽  
Red Cells ◽  
Red Cell ◽  
Cell Volumes

Abstract Serial determinations of red cell volumes were made with an electronic sizing device in 30 patients with hepatic cirrhosis. Variations in red cell volumes were correlated with other hematologic and clinical findings. The results of these studies suggest that volume macrocytosis in patients with alcoholic cirrhosis is either due to megaloblastosis of the bone marrow or to an accelerated influx of young red cells into the peripheral blood.

Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study.

1990 ◽  
Vol 9 (6) ◽  
pp. 610-615 ◽  
Author(s):  
S L Lehmann ◽  
K M Teasley ◽  
N N Konstantinides ◽  
F Konstantinides ◽  
F B Cerra
Keyword(s):  
Growth Hormone ◽  
Pilot Study ◽  
Peripheral Vein

scholarly journals Clinical observations of bone marrow transfusion for promoting bone marrow reconstruction after chemotherapy for AIDS-related lymphoma

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yixuan Liu ◽  
Suhong Xie ◽  
Lei Li ◽  
Yanhui Si ◽  
Weiwei Zhang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
T Lymphocytes ◽  
Peripheral Blood ◽  
Autologous Bone Marrow ◽  
Control Group ◽  
Peripheral Vein ◽  
Significant Difference ◽  
Autologous Bone ◽  
Aids Related Lymphoma

Abstract Background This study investigates the effect of autologous bone marrow transfusion (BMT) on the reconstruction of both bone marrow and the immune system in patients with AIDS-related lymphoma (ARL). Methods A total of 32 patients with ARL participated in this study. Among them, 16 participants were treated with conventional surgery and chemotherapy (control group) and the remaining 16 patients were treated with chemotherapy followed by autologous bone marrow transfusion via a mesenteric vein (8 patients, ABM-MVI group) or a peripheral vein (8 patients, ABM-PI group). Subsequently, peripheral blood and lymphocyte data subsets were detected and documented in all patients. Results Before chemotherapy, no significant difference in indicators was observed between three groups of ARL patients. Unexpectedly, 2 weeks after the end of 6 courses of chemotherapy, the ABM-MVI group, and the ABM-PI group yielded an increased level of CD8+T lymphocytes, white blood cells (WBC), and platelet (PLT) in peripheral blood in comparison to the control group. Notably, the number of CD4+T lymphocytes in the ABM-PI group was significantly higher than that in the other two groups. Additionally, no significant difference in haemoglobin levels was observed before and after chemotherapy in both the ABM-MVI and ABM-PI groups, while haemoglobin levels in the control group decreased significantly following chemotherapy. Conclusions Autologous bone marrow transfusion after chemotherapy can promote the reconstruction of both bone marrow and the immune system. There was no significant difference in bone marrow recovery and reconstruction between the mesenteric vein transfusion group and the peripheral vein transfusion group.

Prevalence of Congenital Anomalies of the Inferior Vena Cava: CT Assessment in Thai Patients

2021 ◽  
Vol 104 (9) ◽  
pp. 1459-1464
Keyword(s):  
Inferior Vena Cava ◽  
Renal Vein ◽  
Inferior Vena ◽  
Left Renal Vein ◽  
Vena Cava ◽  
Renal Veins ◽  
Retrocaval Ureter ◽  
Radiology Reports ◽  
Contrast Enhanced ◽  
Study Population

Objective: To determine the prevalence of inferior vena cava (IVC) anomalies in Thai patients who underwent contrast-enhanced computed tomography (CT) of the abdomen. Materials and Methods: Two radiologists retrospectively and independently reviewed the contrast-enhanced abdominal CT examinations in 1,429 Thai patients between August 1, 2018 and January 25, 2019 who met the inclusion criteria. Patients were included, if (a) their CT showed well visualized IVC, renal veins, and right ureter that were not obliterated by tumor, cyst, fluid collection, or intraperitoneal free fluid, (b) they had not undergone previous abdominal surgery that altered anatomical configuration of the IVC, renal veins, and right ureter. The presence of all IVC anomalies were recorded. Results: Among the 1,429 studied patients, 678 were male (47.4%) and 751 were female (52.6%). The prevalence of IVC anomalies was 3.5%. Five types of IVC anomalies were presented. The most common was circumaortic left renal vein in 24 patients or 48.0% of all IVC anomalies and 1.7% of the study population, followed by retroaortic left renal vein in 15 patients or 30.0 % of all IVC anomalies and 1.0% of the study population. Other IVC anomalies included double IVC, left IVC, and retrocaval ureter at 0.5%, 0.2%, and 0.1% of the study population, respectively. Conclusion: The prevalence of IVC anomalies in the present study differed from the previous studies conducted in other countries, which may be attributable to differences in race and ethnicity. Awareness of these anomalies is essential when evaluating routine CT examinations in asymptomatic patients. Their presence should be carefully noted in radiology reports to avoid anomaly-related complications. Keywords: Prevalence; IVC anomalies; Circumaortic left renal vein; Retroaortic left renal vein; Double IVC; Left IVC; Retrocaval ureter

scholarly journals A case of human monocytic ehrlichiosis in Serbia

2014 ◽  
Vol 142 (1-2) ◽  
pp. 79-82 ◽  
Author(s):  
Bogdan Arsic ◽  
Ana Gligic ◽  
Elizabeta Ristanovic ◽  
Branislav Lako ◽  
Aleksandar Potkonjak ◽  
...  
Keyword(s):  
Indirect Immunofluorescence ◽  
Clinical Picture ◽  
Peripheral Blood ◽  
Immunofluorescence Assay ◽  
High Fever ◽  
Tick Bite ◽  
Indirect Immunofluorescence Assay ◽  
Ehrlichia Chaffeensis ◽  
Serum Samples ◽  
History Of

Introduction. Ehrlichiosis is a bacterial zoonosis transmitted by hematophagous arthropods - ticks. In humans, it occurs as monocytic, granulocytic, and ewingii ehrlichiosis. Pathological process is based on parasitic presence of Ehrlichia organisms within peripheral blood cells - monocytes and granulocytes. Case Outline. Fifty-two year old patient was admitted to hospital due to high fever of over 40?C that lasted two days, accompanied with chills, muscle aches, malaise, loss of appetite, headache, confusion, breathing difficulties, and mild dry cough. The history suggested tick bite that occurred seven days before the onset of disease. Doxycycline was introduced and administered for 14 days, causing the disease to subside. Indirect immunofluorescence assay was used to analyze three serum samples obtained from this patient for Ehrlichia chaffeensis antibodies, and peripheral blood smear was evaluated for the presence of Ehrlichia and Ehrlichia aggregation into morulae. Conclusion. Ehrlichiosis should be considered in each case where there is a history of tick bite together with the clinical picture (high fever, chills, muscle aches, headache, generalized weakness and malaise, and possible maculopapular rash). The presence of Ehrlichia chaffeensis antibodies was confirmed in a patient with the history of tick bite, appropriate clinical picture and indirect immunofluorescence assay. This confirmed the presence of human monocytotropic ehrlichiosis, a disease that is uncommonly identified in our country.

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