scholarly journals Low-dose dexamethasone administration for 3 weeks favorably affects plasma HDL concentration and composition but does not affect very low-density lipoprotein kinetics

2012 ◽  
Vol 167 (2) ◽  
pp. 217-223 ◽  
Author(s):  
Xuewen Wang ◽  
Faidon Magkos ◽  
Bruce W Patterson ◽  
Dominic N Reeds ◽  
Janine Kampelman ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Plasma Lipoprotein ◽  
Metabolic Effects ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Particle Sizes ◽  
Lipoprotein Subclass ◽  
The Metabolic Syndrome

ObjectiveSubclinical hypercortisolemia often occurs in subjects with features of the metabolic syndrome, and it has been suggested that it may be, at least in part, responsible for the development of these metabolic abnormalities. However, the metabolic effects of glucocorticoid administration to mimic subclinical glucocorticoid excess have not been evaluated.MethodsWe used stable isotope-labeled tracer methods in conjunction with magnetic resonance techniques to measure the effect of glucocorticoid excess within the physiological range (∼0.7 mg dexamethasone/day for 3 weeks) on glucose and free fatty acid (FFA) rates of appearance (Ra) into plasma, intrahepatic triglyceride (TG) content, very low-density lipoprotein (VLDL)-TG and VLDL-apolipoprotein B-100 (apoB-100) kinetics and plasma lipoprotein subclass concentrations, and particle sizes in nine overweight and obese individuals.ResultsDexamethasone treatment led to a very small but significant increase in body weight (from 87.4±7.1 to 88.6±7.2 kg; P=0.003) and increased HDL-cholesterol (from 45.9±2.8 to 55.1±4.6 mg/dl; P=0.037) and HDL particle (from 33.7±2.2 to 41.4±4.2 nmol/l; P=0.023) concentrations in plasma but had no effect on intrahepatic TG content, glucose and FFA Ra in plasma, hepatic VLDL-TG and VLDL-apoB-100 secretion rates and mean residence times in the circulation, plasma TG and LDL-cholesterol concentrations, and plasma lipoprotein particle sizes.ConclusionSubclinical hypercortisolemia does not have significant adverse metabolic consequences.

Platelet Aggregation and Plasma Lipoproteins in Alcoholics During Alcohol Withdrawal

1986 ◽  
Vol 55 (02) ◽  
pp. 173-177 ◽  
Author(s):  
K Desai ◽  
J S Owen ◽  
D T Wilson ◽  
R A Hutton
Keyword(s):  
Platelet Aggregation ◽  
Alcohol Withdrawal ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Plasma Lipoprotein ◽  
Cholesterol Concentration ◽  
Arachidonic Acid Content ◽  
Low Density

SummaryPlatelet aggregation, platelet lipid composition and plasma lipoprotein concentrations were measured each week in a group of seventeen alcoholics, without overt liver disease, for one month, following acute, total alcohol withdrawal. The platelets were initially hypoaggregable but, within 1-2 weeks of cessation of drinking, they became hyperaggregable and then gradually returned towards normal values. Hyperaggregability could not be explained by increases in either the cholesterol or the arachidonic acid content of the platelets. Plasma very-low-density lipoprotein cholesterol levels remained high throughout the study, but the initially raised levels of high-density lipoprotein (HDL) cholesterol fell by 26%. Low-density lipoprotein (LDL) cholesterol concentration rose by 10% after two weeks of withdrawal but then returned to about the starting level. The resulting changes in the plasma LDL-cholesterol: HDL-cholesterol ratio, which had increased by more than 50% after two weeks of abstinence, essentially paralleled the time course of enhanced platelet reactivity in all but four of the alcoholics. These findings suggest that alterations in plasma lipoprotein concentrations during acute alcohol withdrawal may be a contributory factor to the haemostatic disorders present in such patients.

scholarly journals Effects of Simvastatin on Plasma Lipoprotein Concentrations and Very-Low-Density Lipoprotein Secretion in the Rat.

1995 ◽  
Vol 18 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Colette SÉROUGNE ◽  
Denis MATHÉ ◽  
Jacqueline FÉRÉZOU ◽  
Catherine BERTIN ◽  
Michel RIOTTOT ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Plasma Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Secretion

scholarly journals PERBANDINGAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN DARAH PADA PRIA PEROKOK DAN BUKAN PEROKOK

2014 ◽  
Vol 1 (2) ◽  
Author(s):  
Defitson Adolfo Gopdianto
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Sampling Technique ◽  
Hdl Cholesterol ◽  
High Density ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Cholesterol Levels

AbstractBackground: Decrease or increase in blood HDL cholesterol levels affect smokers and nonsmokers. Cigarettes have chemicals that can lead to several health problems such as nicotine. Nicotine resulted in the production of very low density lipoprotein(VLDL) in order to reduce redundant high density lipoprotein cholesterol levels.Method: This type of researchis anobservationalstudyusing across sectional design. Thisstudy populationisstudents ofthe Faculty ofMedicine, University ofSamRatulangi7th semesterof the school year2012/2013with apopulation of150people. Sampling technique inthis research is byusingpurposivesamplingtechniques, smokersand nonsmokersobtainedusing a questionnaire.Result: Determinedthatthere is astatisticallysignificant differencebetweenHDLcholesterol levelsin theblood ofmalesmokersand nonsmokersp=0.49.Cinclusion: There isstatistically significantdifferences inHDLcholesterol levelsin theblood ofmalesmokersand nonsmokers.Keywords: HDLcholesterol levels, smokers, and nonsmokersAbstrakLatar belakang: Penurunan atau peningkatan kadar kolesterol HDL darah berpengaruh pada perokok dan bukan perokok. Rokok memiliki bahan-bahan kimiawi yang dapat mengakibatkan beberapa gangguan kesehatan diantaranya adalah nikotin. Nicotineresulted inthe production ofvery low densitylipoprotein(VLDL) in order toreduceexcessivelevels ofhigh densitylipoproteincholesterol.Metode: Jenis penelitian merupakan penelitian observasional dengan menggunakan rancangan cross sectional.Populasi penelitian ini yaitu mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi semester 7 tahun ajaran 2012/2013 dengan besar populasi berjumlah 150 orang. Teknik pengambilan sampel pada penelitian ini yaitu dengan menggunakan teknik purposive sampling, perokok dan bukan perokok didapatkan dengan menggunakan kuesioner.Hasil:Secara statistik ditetapkan bahwa terdapat perbedaan yang bermakna antara kadar kolesterol HDL darah pada pria perokok dan bukan perokok p=0,49.Kesimpulan: Secara statistik ada perbedaan kadar kolesterol HDL darah pada pria perokok dan bukan perokok.Kata kunci: Kadar kolesterol HDL, perokok, dan bukan perokok.

Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycol-modified enzymes and sulfated alpha-cyclodextrin

1995 ◽  
Vol 41 (5) ◽  
pp. 717-723 ◽  
Author(s):  
H Sugiuchi ◽  
Y Uji ◽  
H Okabe ◽  
T Irie ◽  
K Uekama ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
High Density Lipoprotein ◽  
Direct Method ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Automated Method

Abstract We have developed an automated method for measuring high-density lipoprotein (HDL)-cholesterol in serum without prior separation, using polyethylene glycol (PEG)-modified enzymes and sulfated alpha-cyclodextrin. When cholesterol esterase and cholesterol oxidase enzymes were modified with PEG, they showed selective catalytic activities towards lipoprotein fractions, with the reactivity increasing in the order: low-density lipoprotein < very-low-density lipoprotein approximately chylomicron < HDL. In the presence of magnesium ions, alpha-cyclodextrin sulfate reduced the reactivity of cholesterol, especially in chylomicrons and very-low-density lipoprotein, without the need for precipitation of those lipoprotein fractions. The combination of PEG-modified enzymes with alpha-cyclodextrin sulfate provided selectivity for the determination of HDL-cholesterol in serum in the presence of a small amount of dextran sulfate without the need for precipitation of lipoprotein aggregates. The results of the HDL-cholesterol assayed in serum by this direct method correlated well with those obtained by precipitation-based methods and also that by an ultracentrifugation method.

Studies on the Thromboplastic Effect of Human Plasma Lipoproteins

1976 ◽  
Vol 35 (01) ◽  
pp. 178-185 ◽  
Author(s):  
Helena Sandberg ◽  
Lars-Olov Andersson
Keyword(s):  
High Density Lipoprotein ◽  
Human Plasma ◽  
Platelet Rich Plasma ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Plasma Lipoproteins ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Free Plasma ◽  
Good Agreement

SummaryHuman plasma lipoprotein fractions were prepared by flotation in the ultracentrifuge. Addition of these fractions to platelet-rich, platelet-poor and platelet-free plasma affected the partial thromboplastin and Stypven clotting times to various degrees. Addition of high density lipoprotein (HDL) to platelet-poor and platelet-free plasma shortened both the partial thromboplastin and the Stypven time, whereas addition of low density lipoprotein and very low density lipoprotein (LDL + VLDL) fractions only shortened the Stypven time. The additions had little or no effect in platelet-rich plasma.Experiments involving the addition of anti-HDL antibodies to plasmas with different platelet contents and measuring of clotting times produced results that were in good agreement with those noted when lipoprotein was added. The relation between structure and the clot-promoting activity of various phospholipid components is discussed.

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