scholarly journals Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

2014 ◽  
Vol 171 (2) ◽  
pp. 161-170 ◽  
Author(s):  
Kristin Holvik ◽  
Natasja M van Schoor ◽  
Elisabeth M W Eekhoff ◽  
Martin den Heijer ◽  
Dorly J H Deeg ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Population Based ◽  
Metabolic Risk Factors ◽  
Arterial Calcification ◽  
Metabolic Risk ◽  
Increased Risk ◽  
Old Men ◽  
Age And Sex

ObjectiveThe role of osteocalcin (OC) in cardiovascular disease (CVD) is unresolved. We aimed to study the association between plasma OC concentrations and the risk of non-fatal and fatal CVDs. We also aimed to investigate whether such an association, if present, would be mediated by established metabolic risk factors.DesignA population-based longitudinal cohort study.MethodsIn 1995/1996, OC was determined in blood samples drawn from 1319 subjects aged 65–88 years participating in the Longitudinal Aging Study Amsterdam in 1995/1996. The self-reported CVD events were collected every 3 years until 2005/2006, and CVD deaths until 1st January 2007. Cox proportional hazards regression was performed, considering potential confounders (smoking, physical activity, and BMI) and mediators (blood pressure, plasma triglycerides, total and HDL cholesterol, fructosamine, and aortic calcification).ResultsDuring the median 4.1 years follow-up, 709 subjects (53.8%) suffered a CVD event. There was no overall association between OC and CVD: hazard ratio (HR) was 0.97 (95% CI 0.90–1.04) per nmol/l higher plasma OC, adjusted for age and sex. There was a statistical interaction between plasma OC, age, and sex on CVD (P=0.014). In those subjects aged ≥75 years, age-adjusted HRs (95% CI) were 0.86 (0.75–0.99) in men and 1.16 (1.03–1.31) in women per nmol/l higher plasma OC. Adjustment for covariates only slightly attenuated the association in older-old men, but did not affect the association in older-old women.ConclusionA higher plasma OC concentration was associated with a reduced risk of CVD in older-old men and with an increased risk of CVD in older-old women. We found no evidence that this was mediated by arterial calcification or metabolic risk factors.

scholarly journals Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A Population-Based Prospective Cohort Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137609 ◽  
Author(s):  
Fahimeh Ramezani Tehrani ◽  
Seyed Ali Montazeri ◽  
Farhad Hosseinpanah ◽  
Leila Cheraghi ◽  
Hadi Erfani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Polycystic Ovary Syndrome ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Polycystic Ovary ◽  
Population Based ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Ovary Syndrome

scholarly journals Trajectories of Metabolic Risk Factors and Biochemical Markers prior to the Onset of Cardiovascular Disease – The Doetinchem Cohort Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155978 ◽  
Author(s):  
Gerben Hulsegge ◽  
Annemieke M. W. Spijkerman ◽  
Yvonne T. van der Schouw ◽  
Stephan J. L. Bakker ◽  
Ron T. Gansevoort ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Biochemical Markers ◽  
Metabolic Risk Factors ◽  
Metabolic Risk

scholarly journals The Occurrence of Metabolic Risk Factors Stratified by Psoriasis Severity: A Swedish Population-Based Matched Cohort Study

2020 ◽  
Vol Volume 12 ◽  
pp. 737-744
Author(s):  
Mohammadhossein Hajiebrahimi ◽  
Ci Song ◽  
David Hägg ◽  
Therese M-L Andersson ◽  
Reginald Villacorta ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Population Based ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Matched Cohort ◽  
Swedish Population ◽  
Matched Cohort Study ◽  
Psoriasis Severity

Metabolic risk factors for cardiovascular disease in a working population: A retrospective cohort study

1996 ◽  
Vol 49 (3) ◽  
pp. 267-271 ◽  
Author(s):  
Barry Gumbiner ◽  
Elena M. Andresen ◽  
F.Terry Hearne ◽  
T.Erik Michaelson ◽  
Michael Bryson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Working Population

scholarly journals Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results from a Large Population-Based Cohort Study in Austria

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0161376 ◽  
Author(s):  
Emanuel Zitt ◽  
Constanze Pscheidt ◽  
Hans Concin ◽  
Reinhard Kramar ◽  
Karl Lhotta ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Large Population ◽  
Population Based ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Disease Specific

scholarly journals Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease

Diabetologia ◽  
1997 ◽  
Vol 40 (10) ◽  
pp. 1178-1184 ◽  
Author(s):  
C. Couillard ◽  
P. Mauriège ◽  
D. Prud'homme ◽  
A. Nadeau ◽  
A. Tremblay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Gender Differences ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Plasma Leptin

scholarly journals Gender Inequalities in Diagnostic Inertia around the Three Most Prevalent Cardiovascular Risk Studies: Protocol for a Population-Based Cohort Study

2021 ◽  
Vol 18 (8) ◽  
pp. 4054
Author(s):  
Concepción Carratala-Munuera ◽  
Adriana Lopez-Pineda ◽  
Domingo Orozco-Beltran ◽  
Jose A. Quesada ◽  
Jose L. Alfonso-Sanchez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Health Care ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Disease Incidence ◽  
Population Based ◽  
Gender Inequalities ◽  
Primary Health Care Centers

Evidence shows that objectives for detecting and controlling cardiovascular risk factors are not being effectively met, and moreover, outcomes differ between men and women. This study will assess the gender-related differences in diagnostic inertia around the three most prevalent cardiovascular risk factors: dyslipidemia, arterial hypertension, and diabetes mellitus, and to evaluate the consequences on cardiovascular disease incidence. This is an epidemiological and cohort study. Eligible patients will be adults who presented to public primary health care centers in a Spanish region from 2008 to 2011, with hypertension, dyslipidemia, or/and diabetes and without cardiovascular disease. Participants’ electronic health records will be used to collect the study variables in a window of six months from inclusion. Diagnostic inertia of hypertension, dyslipidemia, and/or diabetes is defined as the registry of abnormal diagnostic parameters—but no diagnosis—on the person’s health record. The cohort will be followed from the date of inclusion until the end of 2019. Outcomes will be cardiovascular events, defined as hospital admission due to ischemic cardiopathy, stroke, and death from any cause. The results of this study could inform actions to rectify the structure, organization and training of health care teams in order to correct the inequality.

Sign in / Sign up

Export Citation Format

Share Document