scholarly journals High prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas

2002 ◽  
pp. 741-745 ◽  
Author(s):  
KY Lam ◽  
CY Lo ◽  
PS Leung
Keyword(s):  
Hong Kong ◽  
Chromosomal Translocation ◽  
Anaplastic Thyroid Carcinoma ◽  
Adult Patients ◽  
Hong Kong Chinese ◽  
Papillary Thyroid ◽  
Genetic Event ◽  
Thyroid Carcinomas ◽  
High Prevalence ◽  
Age Range

OBJECTIVE: The activation of RET proto-oncogene, through different types of chromosomal translocation and inversion, is unique to papillary thyroid carcinomas (PTC) and its frequency is variable in different populations. The aim of this study was to investigate the frequency and types of PTC genetic rearrangements in papillary carcinoma in a population of Hong Kong Chinese. METHODS: The presence of RET/PTC1, RET/PTC2 and RET/PTC3 activation was analyzed by RT-PCR in twenty PTC from adult patients (age range 24-63 years), one PTC from a 12-year-old boy and anaplastic carcinomas in two adult patients. RESULTS: RET/PTC3 was the only activation of RET proto-oncogene identified in the samples. Seventeen PTC from adult patients (85%t) were positive for RET/PTC3. RET/PTC3 was also identified in PTC from the child and one of the two patients with anaplastic thyroid carcinoma. CONCLUSIONS: The prevalence of RET/PTC activation in PTC is high and RET/PTC3 is the only type of activation identified in Hong Kong Chinese and is an important genetic event underlying the development of PTC in the population.

scholarly journals BRAFV599EMutation Is the Leading Genetic Event in Adult Sporadic Papillary Thyroid Carcinomas

2004 ◽  
Vol 89 (5) ◽  
pp. 2414-2420 ◽  
Author(s):  
Efisio Puxeddu ◽  
Sonia Moretti ◽  
Rossella Elisei ◽  
Cristina Romei ◽  
Raffaela Pascucci ◽  
...  
Keyword(s):  
Papillary Thyroid ◽  
Genetic Event ◽  
Thyroid Carcinomas

High Prevalence of c-RET Expression in Papillary Thyroid Carcinomas from the Korean Population

Thyroid ◽  
2005 ◽  
Vol 15 (3) ◽  
pp. 259-266 ◽  
Author(s):  
Sihoon Lee ◽  
Soon Won Hong ◽  
Woo Chul Moon ◽  
Myung Ryurl Oh ◽  
Jin Kyung Lee ◽  
...  
Keyword(s):  
Korean Population ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
High Prevalence

scholarly journals Prevalence of toe symphalangism in Hong Kong Chinese population

2019 ◽  
Vol 26 (1) ◽  
pp. 56-60
Author(s):  
Yi-Lok Charis Chan ◽  
Wei-Hei Dao ◽  
Tsang Yeung ◽  
Esther Ching-San Chow
Keyword(s):  
Hong Kong ◽  
Chinese Population ◽  
Asian Population ◽  
Hong Kong Chinese ◽  
Chinese Adult ◽  
Significant Difference ◽  
High Prevalence ◽  
Christian Hospital ◽  
Skeletal Immaturity ◽  
Second Toe

Objective: To explore the prevalence and variations of toe symphalangism in the Hong Kong Chinese population. Methods: A retrospective review of foot radiographs taken in Chinese adult patients admitted to United Christian Hospital from 1 January, 2016 to 31 December, 2016. Exclusion criteria include (1) previous toe amputation, (2) skeletal immaturity, (3) severe deformity, and (4) repeated attendance. The frequencies were compared by χ 2 test. Result: A total of 1364 foot radiographs were reviewed. Six-hundred sixty radiographs were excluded. A total of 704 radiographs were included in this study. There were total 849 feet reviewed (left: 290, right: 269, bilateral: 145). Their mean age (± standard deviation) was 59.5 ± 14.2 years. The prevalence of 2nd, 3rd, 4th, and 5th toe symphalangism was 0.2%, 0.8%, 9.9%, and 76.7%, respectively. The prevalence resembles Asian population. There was no significant difference in the prevalence associated with the following factors: (1) gender and (2) left versus right foot. There was no 4th toe symphalangism without 5th toe involvement. In the 145 bilateral feet radiographs, asymmetrical distribution of toe symphalangism was found in 8.2%. Second toe symphalangism is rare (0.24%). Conclusion: This is the first study in Hong Kong to report prevalence of toe symphalangism in Chinese population. There is a high prevalence rate of 5th toe symphalangism in the Hong Kong Chinese Population. This implies less flexible lesser toes in the Chinese population with higher risks of development of deformities. The clinical implication of such findings needs further research.

scholarly journals Hyalinizing Trabecular Tumor of the Thyroid Gland

2015 ◽  
Vol 30 (1) ◽  
pp. 69-70
Author(s):  
Vincent G. Te ◽  
Jose M. Carnate
Keyword(s):  
Thyroid Gland ◽  
Left Lobe ◽  
Growth Patterns ◽  
Cytokeratin 19 ◽  
Papillary Thyroid ◽  
Psammoma Bodies ◽  
Thyroid Carcinomas ◽  
Hyalinizing Trabecular Tumor ◽  
Clear Cytoplasm ◽  
Age Range

A 34-year-old woman with a 4-year history of a slowly enlarging thyroid gland underwent a total thyroidectomy. Histologic sections showed multinodular colloid goiter. In addition, a 1.2 centimeter diameter discrete mass with a solid white cut surface was noted within the left lobe. Sections from the left lobe mass show a well-demarcated tumor whose cells are arranged in trabecular and nested growth patterns. (Figure 1) The cells are polygonal to spindly and have ample eosinophilic, slightly granular cytoplasm and oval to angular nuclei that are often grooved. (Figure 2) Hyaline material and a delicate fibrovascular stroma surround the nests and trabeculae, and occasional psammoma bodies are seen. (Figure 3) These features led us to a diagnosis of hyalinizing trabecular tumor. Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm of follicular cell derivation.1, 2 The tumor occurs in adults with a wide age range (4th – 7th decades) and a mean age of 47 years. It is more common in females.1 The classic histologic findings are of a solid circumscribed epithelial neoplasm with or without a thin capsule composed of medium to large-sized polygonal to fusiform cells that are arranged in alveolar, trabecular and nested groups. The cells have finely granular, acidophilic, amphophilic or clear cytoplasm. Nuclei often have prominent grooves and small nucleoli. Calcospherites (psammoma bodies) may be present. Colloid is scant or absent. 1, 2, 3   Because of overlapping nuclear features, a follicular variant of papillary thyroid carcinoma is a differential diagnosis. Histologic features are usually sufficient to distinguish the entities as a nested-alveolar architecture is rarely a prominent feature of a papillary carcinoma.2 Immunohistochemistry may be of aid in this distinction especially in difficult cases with limited material. Cytokeratin 19 and HBME1 are negative in HTT and are usually positive in papillary thyroid carcinomas.4, 5, 6 Neuroendocrine markers are also negative in HTT and are positive in medullary thyroid carcinomas and paragangliomas.2   HTT is of uncertain malignant potential, and a 2008 review of 119 HTTs has shown only one case progressing to malignancy.3 The majority of cases have behaved in a benign fashion and thus may be treated conservatively.1

High prevalence of myopia in children and their parents in Hong Kong Chinese Population: the Hong Kong Children Eye Study

2020 ◽  
Vol 98 (5) ◽  
Author(s):  
Jason C. Yam ◽  
Shu Min Tang ◽  
Ka Wai Kam ◽  
Li Jia Chen ◽  
Marco Yu ◽  
...  
Keyword(s):  
Hong Kong ◽  
Chinese Population ◽  
Hong Kong Chinese ◽  
High Prevalence

High prevalence of metabolic syndrome in Hong Kong Chinese—comparison of three diagnostic criteria

2005 ◽  
Vol 69 (2) ◽  
pp. 160-168 ◽  
Author(s):  
Gary Tin-Choi Ko ◽  
Clive Stewart Cockram ◽  
Chun-Chung Chow ◽  
Vincent Yeung ◽  
Wing-Bun Chan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Hong Kong ◽  
Diagnostic Criteria ◽  
Hong Kong Chinese ◽  
High Prevalence
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