Levels of vitamin D in patients with various endocrine disorders

2014 ◽  
Author(s):  
Ekaterina Pigarova ◽  
Larisa Dzeranova ◽  
Liudmila Rozhinskaya ◽  
Alexander Il'in ◽  
Galina Melnichenko
Keyword(s):  
Vitamin D ◽  
Endocrine Disorders

ASSOCIATION OF OVARIAN VITAMIN D AND HORMONE RECEPTORS EXPRESSION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

2021 ◽  
Vol 10 (4) ◽  
pp. 36-42
Author(s):  
S. T. Aigul ◽  
G. A. Demyashkin ◽  
M. R. Orazov ◽  
S. Yu. Kalinchenko ◽  
G. M. Shaimardanova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hormone Receptors ◽  
Polycystic Ovary ◽  
Married Couples ◽  
Ovarian Cysts ◽  
Control Group ◽  
Endocrine Disorders ◽  
Social Burden ◽  
Metabolism Disorder ◽  
Group I

Infertility is one of the most common diseases of the reproductive system, which carries a significant medical and social burden, affecting from 10 to 15% of married couples, and one of the causes of which is polycystic ovarian syndrome (PCOS), associated with menstrual and endocrine disorders. Changes in the concentration of key enzymes of the metabolic pathway of vitamin D in PCOS may affect the regulation of local tissue homeostasis. Mechanisms of inhibition of cell proliferation under the action of vitamin D have not been fully explored. The aim of the study is to investigate the expression of VDR and hormone receptors in the ovaries of women with PCOS. Material and methods. Patients were divided into main (I) and control groups (II), that included women (n=60) aged 18 to 44 years (mean age - 29.1±3.3 years), who at diagnostic laparoscopy due to infertility of unknown cause. Immunohistochemical (IHC) study of ovarian cysts was performed according to a standard protocol using antibodies to VDR, AR, ERß, PR. The expression of VRD, 1α-OH, 24-OH in samples of ovarian cysts was determined by polymerase chain reaction in real time (PCR-RT). Results. The following IHC expression of the studied markers was observed in the samples of the 1st group cysts of women with PCOS: VDR - 67.7±2.1%; AR - 51.7±1.3%; ERß - 23.1±1.2%; PR - 89.3±2.1%. According to PCR-RT data, the relative VDR expression in group I was 4,31±0,18 arb. u., vs 2,17±0,11 arb. u. in the control group. Conclusions. The key role in PCOS pathogenesis is played by complex metabolism disorder of vitamin D and androgen-estrogen balance as well as decrease of ERß and increase of PR expression level.

Association of Vitamin D Pathway Gene CYP27B1 and CYP2R1 Polymorphisms with Autoimmune Endocrine Disorders: A Meta-Analysis

2020 ◽  
Vol 105 (11) ◽  
Author(s):  
Xiaoxi Ma ◽  
Zhiguo Xie ◽  
Jiabi Qin ◽  
Shuoming Luo ◽  
Zhiguang Zhou
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Hashimoto Thyroiditis ◽  
Minor Allele ◽  
Graves Disease ◽  
Endocrine Disorders ◽  
Organ Specific ◽  
Allele Model

Abstract Background Studies on organ-specific autoimmune endocrine disorders showed correlations between disease risks and vitamin D pathways gene variants, such as CYP27B1 rs10877012 and rs4646536, or CYP2R1 rs10741657 single nucleotide polymorphisms. However, previous works presented inconsistent conclusions. Our study aimed at assessing the association of CYP27B1 and CYP2R1 polymorphisms with autoimmune endocrine disorder susceptibility using the meta-analysis method. Methods Case-control studies of the subject of interest were identified from the databases Pubmed, Embase, Cochrane Library, and China National Knowledge Infrastructure. Studies that met inclusion and quality criteria were pooled. Observational outcomes were diagnosis of autoimmune Addison’s disease, Graves disease, Hashimoto thyroiditis, or type 1 diabetes mellitus. Statistical analysis was performed using software STATA 16.0. Results A total of 14 studies involving 12 929 patients (2243 autoimmune Addison disease, 1253 Graves disease, 612 Hashimoto thyroiditis, 8821 type 1 diabetes), and 12 907 healthy control subjects were pooled for meta-analysis. The rs10877012 minor allele A and its homozygote and heterozygote conferred low overall disease risk (OR [odds ratio] = 0.748, 95% CI [confidence interval] 0.620-0.902 in dominant model; OR = 0.709, 95% CI 0.571-0.879 in recessive model; OR = 0.777, 95% CI 0.674-0.895 in the allele model). The population carrying rs4646536 minor allele C and its homozygote and heterozygote showed decreased overall autoimmune endocrine disorders risk (OR = 0.849, 95% CI 0.748-0.963; OR = 0.868, 95% CI 0.790-0.955; OR = 0.915, 95% CI 0.875-0.957 in the dominant, recessive, and allele model, respectively). No significant genetic association was found for rs10741657. Conclusion Our study suggested CYP27B1 polymorphisms rs10877012 minor allele A and rs4646536 minor allele C were negatively related to susceptibilities of organ-specific autoimmune endocrine diseases.

scholarly journals CLINICAL-METABOLIC AND HORMONAL RELATIONSHIPS BETWEEN PARATHYROID DISEASE AND OTHER NON-CANCEROUS ENDOCRINE DISORDERS IN THE CHORNOBYL NPP ACCIDENT SURVIVORS

2021 ◽  
Vol 26 ◽  
pp. 410-425
Author(s):  
O. Kaminskyi ◽  
◽  
O. Kopylova ◽  
D. Afanasyev ◽  
I. Muraviova ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Ionizing Radiation ◽  
Metabolic Disorders ◽  
Strong Association ◽  
Parathyroid Hyperplasia ◽  
Control Group ◽  
Endocrine Disorders ◽  
Exclusion Zone

Objective: to investigate the clinical, hormonal-metabolic and structural features of parathyroid injuries in survivors exposed to ionizing radiation after the Chornobyl NPP accident in adulthood and childhood, both with their connections to other non-cancerous endocrine disorders, and to establish the respective interhormonal and dysmetabolic relationships. Materials and methods. Clinical effects of ionizing radiation on the endocrine system in persons affected by the Chornobyl NPP accident (n = 224) and their descendants (n = 146), compared with the general population sample (n = 70) were the study object. All patients underwent the ultrasound thyroid and parathyroid examination. The generally recognized clinical, anthropometric (body weight, height, thigh volume, body mass index), instrumental (ultrasound examination of thyroid and parathyroid glands), laboratory (biochemical, hormonal), and statistical methods were applied. Parametric and nonparametric statistical methods were used in data processing. The value of p < 0.05 was considered a statistically significant. Results. No significant difference was found in the incidence of carbohydrate metabolic disorders in the Chornobyl NPP (ChNPP) accident consequences clean-up workers (ACCUW), evacuees from the NPP 30-km exclusion zone, residents of radiologically contaminated areas and in the control group in whom the parathyroid hyperplasia was detected. There was a significant increase in the incidence of arterial hypertension among ACCUW who had parathyroid hyperplasia (76.9%) vs. the control group (51.2%). In cases of parathyoid hyperplasia the vitamin D levels were significantly lower than without it. Vitamin D insufficiency/deficiency was found in 94% of the surveyed subjects. The average level of parathyroid hormone in blood serum was significantly higher in the ACCUW of «iodine» period with diagnosed parathyroid hyperplasia than in the control group: (57.2 ± 2.87) pg / ml against (32.74 ± 3.58) pg / ml, p < 0.05. Results of multivariative analysis indicated a strong association of vitamin 25(OH)D insufficiency/deficiency with development of thyroid disease, carbohydrate metabolic disorders, cardiovascular disease, osteopenia/osteoporosis. parathyroid ultrasound scan was at that an effective diagnostic method for primary screening for parathyroid hyperplasia and regular monitoring of the treatment efficiency. When examining children born to parents irradiated after the ChNPPA the parathyroid hyperplasia (58%) and low serum content of vitamin D (11.6 ± 3.5) nmol / l were most often found in children living on radiologically contaminated territories (RCT). A strong correlation was established between the HOMA insulin resistance index and serum content of vitamin D (r = 0.65), parathyroid hormone (r = 0.60), and free thyroxine (r = 0.68) in the group of children born to parents irradiated after the ChNPPA, having got chronic autoimmune thyroiditis, which indicated a relationship between thyroid function, impaired carbohydrate and fat metabolism and the state of parathyroids. Conclusions. No difference in the incidence of carbohydrate metabolic disorders was found in the ChNPP ACCUW, evacuees from the 30-km exclusion zone, and residents of radiologically contaminated territories in whom parathyroid hyperplasia was detected vs. the control group. Patients with parathyroid hyperplasia were found to be defi cient in vitamin D in 94% of cases, and level of latter was significantly lower than under the normal parathyroid size. There was a significant increase in the incidence of diagnosed arterial hypertension among ACCUW who had parathyroid hyperplasia vs. the control group: (76.9 ± 3.5)% vs. (51.2 ± 3.7)%. According to multivariate analysis a strong association between the vitamin 25(OH)D insufficiency/deficiency and development of thyroid disease, carbohydrate metabolic disorders, cardiovascular disease, and osteopenia/osteoporosis was established. The average level of parathyroid hormone in the blood serum of the ChNPP ACCUW of the «iodine» period with diagnosed parathyroid hyperplasia was significantly higher (57.2 ± 2.87) pg / ml against (32.74 ± 3.58) pg / ml; p <0,05) in the control group. Key words: ChNPP accident, irradiation, accident survivors, accident consequences clean-up workers, ionizing radiation, parathyroids, hyperplasia, hyperparathyroidism, thyroid.

scholarly journals SAT-357 First Case in Saudi Arabia Revealing Fahr Syndrome Secondary to Hypoparathyroidism: A Case Report

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Soha Khan ◽  
Ali Saleh Alhamdan ◽  
Ahmed AlGhamdi ◽  
Abdulleh AlShehri ◽  
Najah Douba ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hand Movement ◽  
Neurological Symptoms ◽  
Calcium Deposition ◽  
Medical Illness ◽  
Endocrine Disorders ◽  
Speech Impairment ◽  
Normal Range ◽  
First Case ◽  
Fahr Syndrome

Abstract Introduction: Fahr Syndrome is a rare inherited or sporadic neurological disorder. It is characterized as in abnormal calcium deposition or in other words, calcification in the brain which almost always occurs bilaterally. Patients with Fahr syndrome usually presents with neurological symptoms such as seizures, tetany, speech impairment, dementia, deterioration of intelligence, involuntary movements. The etiology of Fahr syndrome is mostly associated with endocrine disorders especially hypoparathyroidism either primary or secondary or pseudo hyperparathyroidism; including adult onset neurodegenerative conditions, infectious disease like intrauterine and perinatal infections or inherited congenital causes are also considered. Clinical Case The authors report a 33-year-old Ethiopian female not known to any medical illness presented with abnormal involuntary left-hand movement, headache and dizziness. Further examination shows positive Chvostek’s and Trousseau’s signs. In addition, laboratory findings reveal decreased levels of serum calcium (1.227 mmol/L, normal range of 2.2-2.65 mmol/L), serum albumin (33.53 mg/dL, normal range of 35-52 g/L) and parathyroid hormone (0.3pmol/L, normal range of 1.1-8.43 pmol/L), decreased vitamin D serum level (14.52 ng/ml, normal range of 30-75 ng/ml). Interestingly, brain imaging shows bilateral symmetrical subcortical white matter, basal ganglia, cerebellar dentate nuclei calcifications. Thus, Fahr syndrome diagnosis was made. She was promptly treated with calcium and vitamin D replacement. Calcium gluconate was given intravenously with oral calcium carbonate and oral cholecalciferol. The patient recovered with this treatment leading to positive results without any recurring symptoms. INTERNAL Conclusion In conclusion, Fahr syndrome is a rare sequel of hypoparathyroidism, mostly presented with neurological symptoms due to hypocalcemia which after correction subdues the occurring manifestation such as in this case presented. Early diagnosis of Fahr syndrome due to hypoparathyroidism is crucial for prompt treatment and reversal of symptoms also to prevent complications. INTERNAL

scholarly journals MON-381 Endocrinological Evaluation of Adult Thalassemia Patients

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Seda Hanife Oguz ◽  
Mufide Okay ◽  
Sule Unal ◽  
Nilgun Sayinalp ◽  
Ugur Unluturk
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Short Stature ◽  
Vitamin D Deficiency ◽  
Thalassemia Major ◽  
Age At Diagnosis ◽  
Delayed Puberty ◽  
Endocrine Disorders ◽  
Thalassemia Intermedia

Abstract Background: Endocrine disorders are among the most common complications in thalassemia patients. Although cardiac complications are the main cause of mortality, endocrinological disturbances have a significant impact on morbidity and quality of life. Methods: Sixty-eight patients (35 F, 33 M; 60 thalassemia major, 8 thalassemia intermedia) admitted to our outpatient clinic between August 2015 - December 2017 were included in the study. Patients were evaluated for short stature, hypogonadism, glycemic abnormalities, hypoparathyroidism, hypothyroidism and osteoporosis. Results: The average height of thalassemia major patients was 165.67±8.8 cm in men and 155.6±6.6 cm in women. Nine patients had short stature (4 F, 5 E), but 91.5% (54/59) of the whole group had low IGF-1 levels. There were 23 thalassemia major patients (11 F, 12 M) who had a history of hormonal induction therapy for delayed puberty. Overall, 60% (n = 36) of the patients were currently receiving hormone replacement therapy for central hypogonadism (19 F, 17 M). The median age at diagnosis of central hypogonadism was 22.5 years in men (IQR: 16.5-27.5) and 18 years in women (IQR: 16-25). There were five diabetic thalassemia major patients in study group whose median age at diagnosis was 20 (16-36). Of the 47 patients who underwent OGTT, 13 thalassemia major patients had prediabetes (27.7%). None of the thalassemia intermedia patients had glycemic abnormalities. Subclinical hypothyroidism was present in 19.7% (13/66) of the whole group, hypoparathyroidism was found in 8.5% (9/59) of thalassemia major patients, and vitamin D deficiency (25OH D &lt; 20 ng/ml) was found in 70.8% (46/65) of all patients. Of 64 patients who underwent BMD, 25 had osteoporosis (39.1%) while 23 hadosteopenia (35.9%). The incidence of pathological fractures in thalassemia major patients was 20% (11/55). Conclusions: The incidence of endocrine disorders may increase in thalassemia patients due to prolonged duration of lifespan. Regular screening for newly emerging endocrinopathies during adulthood has great value. In our study, the most common endocrine disorders were vitamin D deficiency, hypogonadism, osteoporosis and glycemic abnormalities; respectively. Early diagnosis and treatment would prevent patients from having related morbidities and therefore increase quality of life.

scholarly journals Decreased serum level of gamma-amino butyric acid in Egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25(OH) vitamin D levels

2019 ◽  
Vol 38 (4) ◽  
pp. 512-518 ◽  
Author(s):  
Rasha A. Radwan ◽  
Nermeen Z. Abuelezz ◽  
Sahar M. Abdelraouf ◽  
Engy M. Bakeer ◽  
Abdullah A. Abd El Rahman
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Total Testosterone ◽  
Endocrine Disorders ◽  
Gamma Aminobutyric Acid ◽  
Gaba Level ◽  
Ovary Syndrome ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

SummaryBackgroundPolycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders around the world. Increasing evidence suggests that neurotransmitter Gamma-aminobutyric acid (GABA) is involved in the pathogenesis of PCOS through its central role in the hypothalamus. However, the peripheral role of GABA in PCOS has not been sufficiently investigated in spite of its existence in peripheral organs. First, the aim of this study is to, investigate serum GABA level in Egyptian PCOS patients. Second, to explore the correlation between serum GABA level with Body Mass Index (BMI), dyslipidemia, totaltestosterone and 25 (OH) vitamin D.MethodsEighty PCOS patients and eighty age-matched healthy females were included in this study. All parameters were assessed colourimetrically or with ELISA.ResultsPCOS patients exhibited significantly decreased serum GABA level compared to controls (p < 0.001). There was a significant positive correlation between serum GABA and 25(OH) vitamin D levels (r = 0.26, p = 0.018), and a significant negative correlation with total testosterone (r = - 0.3, p = 0.02), total cholesterol (TC) (r = - 0.31, p = 0.01) and LDL-Cholesterol (LDL-C) (r = - 0.23, p = 0.045), respectively.ConclusionsThe findings of this study suggest that disrupted GABA level in the peripheral circulation is an additional contributing factor to PCOS manifestations. GABA deficiency was correlated with 25 (OH) vitamin D deficiency, dyslipidemia, and total testosterone. Further investigations for GABA adjustment might provide a promising means for better management of PCOS symptoms.

scholarly journals Interrelation of auto-immune process, endocrine disorders and depression

2020 ◽  
pp. 8-19 ◽  
Author(s):  
M. A. Mayorova ◽  
N. N. Petrova ◽  
U. I. Stroev ◽  
L. P. Churilov ◽  
Y. Shoenfeld
Keyword(s):  
Vitamin D ◽  
Affective Disorders ◽  
T Regulatory Cells ◽  
Stress Hormones ◽  
Negative Influence ◽  
Kynurenine Pathway ◽  
Endocrine Disorders ◽  
Psychiatric Diseases ◽  
Endocrine Regulation ◽  
Regulatory Cells

Disturbances in immune and endocrine regulation are closely interrelated with development of psychiatric diseases, including affective disorders. Depression may be a characteristic of at least 23 autoimmune diseases. Negative influence on the depression development have: an increased level of proinflammatory cytokines, impairment of T-regulatory cells, kynurenine pathway shift towards production of its potentially neurotoxic metabolites, overproduction of stress hormones, hyperleptinemia, hyperprolactinemia, hypothyroidism, as well as vitamin D, calcidiol and calcitriol deficiency. In this review we analysed the development and accumulation of ideas and facts regarding the interrelation between autoimmune and affective pathology.

scholarly journals Dependent and independent causes of hypercalcemia

2022 ◽  
Author(s):  
Rahmathulla Safiyul Rahman ◽  
Hussain Fuad Al-Saffar ◽  
Omar Abdu Alasiri ◽  
Nada Jameel Alata ◽  
Abdulaziz Abdulmajeed Almalki ◽  
...  
Keyword(s):  
Vitamin D ◽  
Clinical Studies ◽  
Endocrine Disorders ◽  
Prevalence Rates ◽  
Common Etiology ◽  
Different Populations ◽  
Granulomatous Diseases

Previous clinical studies show that the condition is significantly associated with mortality and increased cardiovascular morbidities. Accordingly, it is essential to conduct adequate diagnosis and evaluation to assess these cases properly. Studies show that different etiologies have been associated with hypercalcemia development with variable prevalence rates among different populations. Reduced PTH levels among patients with hypercalcemia indicate the presence of a non-PTH-dependant etiology for hypercalcemia. We have discussed various causes of hypercalcemia, including dependant and non-dependant causes. We found that malignancy-induced hypercalcemia is the commonest non-PTH-dependant etiology of hypercalcemia. Many malignancies were reported in the literature to attribute to the development of hypercalcemia. Vitamin D-mediated hypercalcemia was also reported as another common etiology for the condition. It might occur secondary to overdosing, immobilization, endocrine disorders, and granulomatous diseases. Other familial and congenital causes were also reported in the literature and discussed.

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