Clinicopathologic features, treatments, and survival of patients with ectopic Cushing's syndrome from neuroendocrine tumours: data from an Italian multicentre study

Author(s):  
Maria Vittoria Davi ◽  
Elisa Cosaro ◽  
Serena Piacentini ◽  
Giuseppe Reimondo ◽  
Nora Albiger ◽  
...  
Author(s):  
Fernando Guerrero-Pérez ◽  
Inmaculada Peiró ◽  
Agustina Pia Marengo ◽  
Alex Teulé ◽  
José Carlos Ruffinelli ◽  
...  

2021 ◽  
pp. 919-926
Author(s):  
Scott Weerasuriya ◽  
Kieran Palmer ◽  
Stephen Gregory ◽  
Benjamin C. Whitelaw ◽  
Elisa Gonzalez ◽  
...  

Pancreatic neuroendocrine tumours can have varied and complex presentations. Whilst hormone hypersecretion often induces characteristic clinical syndromes, non-specific symptoms may arise due to localized tumour effects. Malignant invasion of local vasculature is an increasingly recognized complication of these neoplasms and can be associated with significant morbidity. Herein, we present the case of a 47-year-old male with a recurrence of a pancreatic neuroendocrine tumour who presented with unusual upper gastrointestinal bleeding. The tumour had recurred within the superior mesenteric vein, replacing the vessel and invading its branches. This resulted in porto-mesenteric hypertension and the formation of bleeding mesenteric varices. The patient subsequently developed progressive metabolic disturbances and was diagnosed with ectopic Cushing’s syndrome, despite his primary tumour having been non-functional. This case demonstrates not only a rare pattern of tumour recurrence but also the potential for pancreatic neuroendocrine tumours to de-differentiate and change from non-functional to hormone secreting, a phenomenon which may complicate diagnosis and management.


2010 ◽  
pp. P3-632-P3-632
Author(s):  
S Ejaz ◽  
SG Waguespack ◽  
RV Sellin ◽  
NL Busaidy ◽  
C Jimenez ◽  
...  

2018 ◽  
Vol 160 (5) ◽  
pp. 1023-1026 ◽  
Author(s):  
Kenny Yu ◽  
Federico Roncaroli ◽  
Tara Kearney ◽  
David Ewins ◽  
Deepa Beeharry ◽  
...  

2021 ◽  
Author(s):  
Sara Pinheiro ◽  
Juliana Filipe ◽  
Pedro Meireles ◽  
Branco Sara Castelo ◽  
Miguel Rito ◽  
...  

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