The effect of corticosteroids on development of femoral head osteonecrosis in patients after kidney transplantation

2017 ◽  
Author(s):  
Enis Gursel ◽  
Omer Faruk Bilgen ◽  
Sadik Bilgen ◽  
Basak Erdemli Gursel ◽  
Canan Ersoy ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Femoral Head ◽  
Femoral Head Osteonecrosis

Epidemiological Study of Femoral Head Osteonecrosis

2017 ◽  
Vol 68 (5) ◽  
pp. 974-976
Author(s):  
Alexandru Patrascu ◽  
Liliana Savin ◽  
Dan Mihailescu ◽  
Victor Grigorescu ◽  
carmen Grierosu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Femoral Head ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Young Patients ◽  
Head Group ◽  
Bipolar Hemiarthroplasty ◽  
Aseptic Necrosis ◽  
Total Hip ◽  
Femoral Head Osteonecrosis

In recent years, there has been an increase in the number of studies on the etiology of femoral head necrosis. We retrospectively reviewed all patients diagnosed with aseptic necrosis of the femoral in the period of 2010-2015. We recorded a total of 230 cases diagnosed with aseptic necrosis of the femoral head, group was composed of 65.7% men and 34.3% women, risk factors identified was 19.13% (post-traumatic), 13.91% (glucocorticoids), 26.52% (alcohol), 3.47% (another cause) and in 36 95% of the cases no risk factors were found. The results of the study based on the type of surgery performed on the basis of stages of disease progression, 8 patients (3.48%) benefited from osteotomy, 28 patients (12.17%) benefited of bipolar hemiarthroplasty prosthesis and 188 patients (81.74%) benefited of total hip arthroplasty. Osteonecrosis of the femoral head is characteristic to young patients between the age of 30-50 years old. Predisposing factors, alcohol and corticosteroid therapy remains an important cause of the disease. Total hip arthroplasty remains the best option for the patients with osteonecrosis of the femoral head.

scholarly journals Outcome after a new porous tantalum rod implantation for treatment of early-stage femoral head osteonecrosis

2019 ◽  
Vol 7 (18) ◽  
pp. 441-441 ◽  
Author(s):  
Wei Huang ◽  
Xuan Gong ◽  
Steve Sandiford ◽  
Xiaoqiang He ◽  
Feilong Li ◽  
...  
Keyword(s):  
Femoral Head ◽  
Early Stage ◽  
Porous Tantalum ◽  
Femoral Head Osteonecrosis

A poly(propylene fumarate) – Calcium phosphate based angiogenic injectable bone cement for femoral head osteonecrosis

Biomaterials ◽  
2010 ◽  
Vol 31 (14) ◽  
pp. 4048-4055 ◽  
Author(s):  
Chih-Hung Chang ◽  
Tai-Chieh Liao ◽  
Yuan-Ming Hsu ◽  
Hsu-Wei Fang ◽  
Chia-Chun Chen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Femoral Head ◽  
Bone Cement ◽  
Femoral Head Osteonecrosis ◽  
Poly Propylene

Septic arthritis of the hip in patients with femoral head osteonecrosis

2011 ◽  
Vol 131 (11) ◽  
pp. 1585-1590 ◽  
Author(s):  
Young-Kyun Lee ◽  
Yun Jong Lee ◽  
Yong-Chan Ha ◽  
Ki-Choul Kim ◽  
Kyung-Hoi Koo
Keyword(s):  
Femoral Head ◽  
Septic Arthritis ◽  
Femoral Head Osteonecrosis

Recent Methods of Neck Femur Fixation A Systematic review and meta-analysis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed Salem Eid ◽  
Ahmed Mohamed Mohasseb ◽  
Ramy Mohamed Mohamed El-Bahnasy
Keyword(s):  
Systematic Review ◽  
Femoral Head ◽  
Femoral Neck ◽  
High Energy ◽  
Femoral Neck Fractures ◽  
Final Outcome ◽  
Cannulated Screws ◽  
Fixed Angle ◽  
Femur Fractures ◽  
Femoral Head Osteonecrosis

Abstract Background Femoral neck fractures in adults younger than age 50 years are uncommon and often the result of high energy trauma. They account for only 2-3% of all femoral neck fractures. Femoral neck fractures are associated with aging and osteoporosis and can occur after relatively trivial trauma in elderly patients. femoral neck fractures are associated with higher incidences of femoral head osteonecrosis and nonunion. Fixation options include cannulated screws, non parallel cannulated screws, medial augmentation plate, and fixed angle femoral neck fixation implants. A systematic review of literature done to evaluate which technique is better. Methods After literature search thirteen articles were found and were reviewed to evaluate final outcome of fixation of neck femur fractures by cannulated screws, non parallel cannulated screws, medial augmentation plate, and fixed angle femoral neck fixation implants. Results After evaluation of all studies the incidence of nonunion, osteonecrosis of femoral head, implant failure & revesion surgery is lower in comparing Targon plate with multiple cannulated screws while we need further studies for application of non parallel screws and medial plate. Conclusion Targon plate recorded low incidence of complications in the final outcome in comparison with multiple cannulated screw while we need further studies for application of Non parallel screws and medial plate.

Iliac Graft Vascularization for Femoral Head Osteonecrosis

2006 ◽  
Vol 442 ◽  
pp. 171-179 ◽  
Author(s):  
Dewei Zhao ◽  
Dachuan Xu ◽  
Weiming Wang ◽  
Xu Cui
Keyword(s):  
Femoral Head ◽  
Femoral Head Osteonecrosis

scholarly journals Corticosteroid induced avascular necrosis and COVID-19: The drug dilemma

2021 ◽  
Vol 11 (3) ◽  
pp. 1049-1052
Author(s):  
Indrajit Banerjee ◽  
Jared Robinson ◽  
Brijesh Sathian
Keyword(s):  
Adverse Effect ◽  
Femoral Head ◽  
Avascular Necrosis ◽  
Steroid Therapy ◽  
Case Reports ◽  
Weight Bearing ◽  
Inflammatory Cells ◽  
High Dose ◽  
Intraosseous Pressure ◽  
Femoral Head Osteonecrosis

The severe and life-threatening nature of the COVID-19 infection, the ARDS (acute respiratory distress syndrome) as well as the cytokine storm induced by the infection, commands lifesaving high doses of steroid therapy. As in all pharmacological therapies adverse effects are present. One such adverse effect which is being reported is corticosteroid induced avascular necrosis of the femoral head/ osteonecrosis of the femoral head. It must be noted that AVN principally affects the femoral head and most commonly the anterolateral aspect thereof as it is the crux of weight bearing.  Corticosteroids induce fat mobilization and this thus innately enhances the likelihood of fat emboli developing from the liver to occlude minor blood vessels in the femur, this thereby compromises the microvascular environment. Superadded to this the steroid therapy disrupts calcium metabolism and homeostasis which induces hypertrophy in the intramedullary fat cells, Gaucher cells and inflammatory cells; whilst increasing the activity of osteoclasts, thus increasing bone resorption and decreasing calcium uptake and deposition; ultimately leading to an insufficiency in the trabecular and cortical bone. This insufficiency thus equates to an increased intraosseous pressure which impedes intramedullary circulation and results in avascular necrosis.  It is evident that avascular necrosis is directly caused by high dose steroid therapy, however the case reports have very clearly indicated that the rapid onset of AVN post recovery from the COVID-19 infection cannot be solely attributed to steroid therapy and that another benefactor induced by the COVID-19 infection is at play. It is thus vital for treating physicians to take cognisance of this adverse effect post recovery and therefore should ensure that prophylactic bisphosphonate therapy is initiated timeously and congruently.

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