Physiological versus synthetic oestrogen therapy and bone mineral density in premature ovarian insufficiency

2018 ◽  
Author(s):  
Eileen Chen ◽  
Ian Seetho ◽  
Jane MacDougall
2014 ◽  
Vol 31 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Hanadi Bakhsh ◽  
Metella Dei ◽  
Sandra Bucciantini ◽  
Daniela Balzi ◽  
Vincenzina Bruni

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 199-200
Author(s):  
Kate Maclaran ◽  
Marie Gerval ◽  
Laura Cucinella ◽  
Geetika Shah ◽  
Winston Banya ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0164638 ◽  
Author(s):  
Anne Bachelot ◽  
Carole Nicolas ◽  
Solenne Gricourt ◽  
Jérôme Dulon ◽  
Monique Leban ◽  
...  

Maturitas ◽  
2021 ◽  
Vol 152 ◽  
pp. 76
Author(s):  
Patricia Muro Blanc ◽  
Misericordia Guinot Gasull ◽  
Laura Balcells Eichenberger ◽  
Elisabet Robert Marchal ◽  
Beatriz Roca Comella ◽  
...  

2021 ◽  
Vol 7 (3) ◽  
pp. e001112
Author(s):  
Karoline Aalberg ◽  
Knut Stavem ◽  
Frode Norheim ◽  
Michael Bjørn Russell ◽  
Aleksander Chaibi

BackgroundFemale athletes might develop reduced bone mineral density (BMD) and amenorrhoea due to low energy intake.ObjectiveTo systematically review the literature of randomised controlled trials (RCTs) assessing the effect of oestrogen oral contraceptives (OCP), conjugated oestrogens (CE) and transdermal estradiol (TE) on BMD in premenopausal women with functional hypothalamic amenorrhoea (FHA) due to weight loss, vigorous exercise and/or stress.MethodsA comprehensive literature search in PubMed, MEDLINE, Cochrane Library, Ovid and CINAHL from inception to 1 October 2020.Data extraction and synthesisTwo authors independently extracted data. When possible, the data were pooled in a random-effects meta-analysis.Main outcomesDifference in BMD (g/cm2) at the lumbar spine.ResultsNine RCTs comprising 770 participants met the inclusion criteria; five studies applied OCP, two CE and two TE. Four RCTs (two OCP, two TE) found an increased BMD in premenopausal women with FHA, and five (three OCP, two CE) found a decreased BMD compared with controls. A meta-analysis showed no difference in BMD between the treatment and control groups, (standardised mean difference (SMD) 0.30, 95% CI −0.12 to 0.73). A secondary analysis for change scores from baseline to first assessment point, showed a similar overall result (SMD 0.17, 95% CI −0.16 to 0.51). No serious adverse events were reported.ConclusionThe literature suggests that TE might increase lumbar BMD in premenopausal women with FHA, but pooled results revealed no effect of the intervention. The findings do not support oestrogen therapy to improve BMD in these patient groups.


2001 ◽  
Vol 120 (5) ◽  
pp. A564-A564
Author(s):  
K ISLAM ◽  
S CREECH ◽  
R SOKHI ◽  
R KONDAVEETI ◽  
A NADIR ◽  
...  

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