Maternal Smoking During Pregnancy Affects Adult Onset of Asthma in Offspring: A Follow Up From Birth to Age 46 Years

PEDIATRICS ◽  
2021 ◽  
Vol 148 (Supplement 3) ◽  
pp. S41-S42
Author(s):  
Aileen E. O’Hayer ◽  
Kirsten M. Kloepfer
Keyword(s):  
Maternal Smoking ◽  
Adult Onset ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Maternal smoking during pregnancy and reproductive health of daughters: a follow-up study spanning two decades

2012 ◽  
Vol 27 (12) ◽  
pp. 3593-3600 ◽  
Author(s):  
A. Ernst ◽  
S.L. Kristensen ◽  
G. Toft ◽  
A.M. Thulstrup ◽  
L.B. Håkonsen ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Follow Up Study ◽  
Maternal Smoking During Pregnancy

scholarly journals Maternal smoking during pregnancy in relation to child overweight: follow-up to age 8 years

2005 ◽  
Vol 35 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Aimin Chen ◽  
Michael L Pennell ◽  
Mark A Klebanoff ◽  
Walter J Rogan ◽  
Matthew P Longnecker
Keyword(s):  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Child Overweight ◽  
Maternal Smoking During Pregnancy

scholarly journals Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

2020 ◽  
Vol 55 (6) ◽  
pp. 1901857 ◽  
Author(s):  
Sanna Toppila-Salmi ◽  
Annika T. Luukkainen ◽  
Baizhuang Xu ◽  
Jussi Lampi ◽  
Juha Auvinen ◽  
...  
Keyword(s):  
Cumulative Incidence ◽  
Maternal Smoking ◽  
Forced Expiratory Volume ◽  
Smoke Exposure ◽  
P Value ◽  
Adult Onset ◽  
Long Term Effects ◽  
Smoking During Pregnancy ◽  
Respiratory Problems ◽  
Maternal Smoking During Pregnancy

RationaleEnvironmental tobacco smoke (ETS) exposure increases asthma risk in children. There is limited knowledge of prenatal ETS for adult-onset asthma.ObjectivesTo determine the association between prenatal ETS and adult onset asthma.Measurements and main resultsThe questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by 31 years of age, who were included in the Northern Finland Birth Cohort 1966 Study was used. The association of maternal smoking during the last 3 months of pregnancy with onset of physician-diagnosed asthma and with lung function in adult offspring was studied using adjusted multivariate regression analyses. The cumulative incidence of physician-diagnosed asthma between the ages of 31 and 46 years was 5.1% among men and 8.8% among women. Gestational smoke exposure was associated with adult-onset asthma among offspring (adjusted OR 1.54, 95% CI 1.04–2.29), namely among offspring who reported either past non-diagnosed asthma (OR 9.63, 95% CI 2.28–40.67) or past cough with wheeze (3.21, 95% CI 1.71–6.05). A significant association was detected between gestational smoke exposure and the offspring's forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio at 31 years of age. In offspring with the haplotype rs11702779-AA of RUNX1, gestational smoke exposure was associated with adult-onset asthma (5.53, 95% CI 2.11–14.52, adjusted p-value for interaction 0.10).ConclusionMaternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects.

scholarly journals Maternal smoking during pregnancy and fractures in offspring: national register based sibling comparison study

BMJ ◽  
2020 ◽  
pp. l7057 ◽  
Author(s):  
Judith S Brand ◽  
Ayako Hiyoshi ◽  
Yang Cao ◽  
Deborah A Lawlor ◽  
Sven Cnattingius ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Maternal Smoking ◽  
National Register ◽  
Smoking During Pregnancy ◽  
Risk Of Fracture ◽  
Sibling Comparison ◽  
Maternal Smoking During Pregnancy ◽  
The Impact ◽  
Dose Dependent

Abstract Objective To study the impact of maternal smoking during pregnancy on fractures in offspring during different developmental stages of life. Design National register based birth cohort study with a sibling comparison design. Setting Sweden. Participants 1 680 307 people born in Sweden between 1983 and 2000 to women who smoked (n=377 367, 22.5%) and did not smoke (n=1 302 940) in early pregnancy. Follow-up was until 31 December 2014. Main outcome measure Fractures by attained age up to 32 years. Results During a median follow-up of 21.1 years, 377 970 fractures were observed (the overall incidence rate for fracture standardised by calendar year of birth was 11.8 per 1000 person years). The association between maternal smoking during pregnancy and risk of fracture in offspring differed by attained age. Maternal smoking was associated with a higher rate of fractures in offspring before 1 year of age in the entire cohort (birth year standardised fracture rates in those exposed and unexposed to maternal smoking were 1.59 and 1.28 per 1000 person years, respectively). After adjustment for potential confounders the hazard ratio for maternal smoking compared with no smoking was 1.27 (95% confidence interval 1.12 to 1.45). This association followed a dose dependent pattern (compared with no smoking, hazard ratios for 1-9 cigarettes/day and ≥10 cigarettes/day were 1.20 (95% confidence interval 1.03 to 1.39) and 1.41 (1.18 to 1.69), respectively) and persisted in within-sibship comparisons although with wider confidence intervals (compared with no smoking, 1.58 (1.01 to 2.46)). Maternal smoking during pregnancy was also associated with an increased fracture incidence in offspring from age 5 to 32 years in whole cohort analyses, but these associations did not follow a dose dependent gradient. In within-sibship analyses, which controls for confounding by measured and unmeasured shared familial factors, corresponding point estimates were all close to null. Maternal smoking was not associated with risk of fracture in offspring between the ages of 1 and 5 years in any of the models. Conclusion Prenatal exposure to maternal smoking is associated with an increased rate of fracture during the first year of life but does not seem to have a long lasting biological influence on fractures later in childhood and up to early adulthood.

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