SPLIT PRODUCTS OF FIBRIN IN THE SERUM OF NEWBORNS

PEDIATRICS ◽  
1969 ◽  
Vol 43 (5) ◽  
pp. 770-780
Author(s):  
E. Richard Stiehm ◽  
Dallas V. Clatanoff
Keyword(s):  
Birth Weight ◽  
Cesarean Section ◽  
Respiratory Distress ◽  
Newborn Infants ◽  
Coagulation Factors ◽  
Low Birth Weight Infants ◽  
Pathologic Condition ◽  
Cord Serum ◽  
Internal Bleeding ◽  
Term Newborns

Levels of split products of fibrin (SPF), as measured by an immunologic tube precipitin method, were studied in cord and maternal sera obtained shortly after delivery. One hundred thirty-seven of 208 (65%) of vaginally delivered, term newborns, 28 of 48 (58%) of cesarean section delivered newborns, and 9 of 13 (69%) of low birth weight infants had SPF in their cord serum. Serial studies in 14 infants indicate that SPF disappeared from the serum within 24 hours with a half-life of 3 to 6 hours. The presence of SPF in the serum of newborn infants after 24 hours (found in 7 of 11 sick infants in this study) suggests a pathologic condition associated with fibrin breakdown such as sepsis, respiratory distress, or internal bleeding. Cord serum SPF levels were not correlated with levels of other coagulation factors, nor with clinical features such as length of labor. Since SPF in cord serum are not increased in traumatic delivery, we conclude that their origin is the continuous lysis of clots within the placenta. SPF were also present in 23 of 77 (30%) maternal sera obtained immediately after delivery. There was no correlation between maternal and cord serum SPF levels and their pattern differed on immunoelectrophoresis. Maternal SPF levels appear during labor and disapppear shortly after delivery.

Early versus late treatment of neonatal acidosis in low-birth-weight infants: Relation to respiratory distress syndrome

1972 ◽  
Vol 81 (6) ◽  
pp. 1178-1187 ◽  
Author(s):  
Calvin J. Hobel ◽  
William Oh ◽  
Marcia A. Hyvarinen ◽  
George C. Emmanouilides ◽  
Allen Erenberg
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Low Birth Weight Infants ◽  
Late Treatment

Passage of the First Stool in Very Low Birth Weight Infants

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 1005-1007
Author(s):  
Meenakshi K. Jhaveri ◽  
Savitri P. Kumar
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Very Low Birth Weight ◽  
Gut Hormones ◽  
Low Birth Weight Infants ◽  
Severe Respiratory Distress ◽  
Severe Respiratory Distress Syndrome

Times of first stool passage were studied in 171 infants who weighed less than 1,500 g at birth. Delayed passage (greater than 48 hours) was noted in 20.4% of this group. Significant differences were noted between the delayed and nondelayed groups for gestational age, presence of severe respiratory distress syndrome, and the time of the first enteral feeding. In very low birth weight infants, delay in the passage of the first stool is a common occurrence. This delay is probably due to physiologic immaturity of the motor mechanisms of the gut, lack of triggering effect of enteral feeds on gut hormones, and the presence of severe respiratory distress syndrome, which may singly or in concert adversely affect gastrointestinal motility.

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