Diarrhea in Breast-Fed and Non-Breast-Fed Infants

PEDIATRICS ◽  
1982 ◽  
Vol 70 (6) ◽  
pp. 921-925
Author(s):  
Alice H. Cushing ◽  
Linda Anderson
Keyword(s):  
Breast Milk ◽  
First Year ◽  
Milk Samples ◽  
Colonization Factor ◽  
Fecal Carriage ◽  
Heat Labile ◽  
Insignificant Difference ◽  
First Year Of Life ◽  
Breast Fed

During the first year of life a group of babies was prospectively observed for diarrhea and for fecal carriage of heat-labile toxigenic bacteria, with or without colonization factor, and rotavirus. Approximately half of the babies were breast-fed for the first six months of life. There was no difference between groups (breast-fed vs non-breast-fed) in number of babies who had diarrhea during any two-month period. Nor was there any difference between groups in the number of babies who had diarrhea while carrying toxigenic bacteria, with or without colonization factor. Secretory antibody to toxin was found in 37% of colostrum and milk samples. There was a small but insignificant difference in the number of babies who had diarrhea when they carried toxigenic bacteria depending on the presence of antibody in the breast milk they received.

scholarly journals Immunological programming by breast milk creates an anti-inflammatory cytokine milieu in breast-fed infants compared to formula-fed infants

2012 ◽  
Vol 109 (11) ◽  
pp. 1962-1970 ◽  
Author(s):  
Essi Kainonen ◽  
Samuli Rautava ◽  
Erika Isolauri
Keyword(s):  
Breast Milk ◽  
Breast Feeding ◽  
Allergic Disease ◽  
Inflammatory Cytokine ◽  
First Year ◽  
Tnf Α ◽  
Cytokine Milieu ◽  
First Year Of Life ◽  
Anti Inflammatory Cytokine ◽  
Breast Fed

Breast milk provides important maturational stimuli to an infant's developing immune system. However, data concerning the role of breast-feeding in reducing the risk of allergic disease remain contradictory. Previous studies have centred on comparative analyses of breast milk and formula compositions. We chose a slightly different angle, whereby we focused on the effects of the chosen diet on the infant himself, comparing the immune development of formula-fed and breast-fed children. The objective of the present study was to determine how the mode of feeding affects infant immunology. Altogether, eighteen formula-fed infants with limited breast-feeding for < 3 months and twenty-nine infants who were exclusively breast-fed for >3 months were included in the study. Concentrations of interferon γ, TNF-α IL-10, IL-5, IL-4 and IL-2 were measured simultaneously from the same serum sample through use of a multiplexed flow cytometric assay at the ages of 1, 3, 6 and 12 months. Transforming growth factor β2 (TGF-β2) was measured using ELISA at the same time points. Serum TNF-α and IL-2 concentrations were significantly higher in formula-fed than in breast-fed infants during the first year of life (ANOVA, P= 0·002). The serum concentrations of TGF-β were significantly lower in formula-fed than in breast-fed infants throughout the first year of life (ANOVA, P≤ 0·0001). Exclusive breast-feeding promotes an anti-inflammatory cytokine milieu, which is maintained throughout infancy. Such an immunological environment limits hyper-responsiveness and promotes tolerisation, possibly prohibiting the onset of allergic disease.

scholarly journals Infant Feeding Alters the Longitudinal Impact of Birth Mode on the Development of the Gut Microbiota in the First Year of Life

2021 ◽  
Vol 12 ◽  
Author(s):  
Modupe O. Coker ◽  
Hannah E. Laue ◽  
Anne G. Hoen ◽  
Margaret Hilliard ◽  
Erika Dade ◽  
...  
Keyword(s):  
Breast Milk ◽  
Infant Feeding ◽  
Taxonomic Composition ◽  
First Year ◽  
Delivery Mode ◽  
Longitudinal Impact ◽  
Health Promoting ◽  
Duration Of Breastfeeding ◽  
First Year Of Life ◽  
Breast Fed

Cesarean-delivered (CD) infants harbor a distinct gut microbiome from vaginally delivered (VD) infants, however, during infancy, the most important driver of infant gut microbial colonization is infant feeding. Earlier studies have shown that breastfeeding is associated with higher levels of health-promoting bacteria such and Bifidobacterium and Bacteroides via modulation of the immune system, and production of metabolites. As the infant gut matures and solid foods are introduced, it is unclear whether longer duration of breast feeding restore loss of beneficial taxa within the intestinal microbiota of operatively delivered infants. Within the New Hampshire Birth Cohort Study, we evaluated the longitudinal effect of delivery mode and infant feeding on the taxonomic composition and functional capacity of developing gut microbiota in the First year of life. Microbiota of 500 stool samples collected between 6 weeks and 12 months of age (from 229 infants) were characterized by 16S ribosomal RNA sequencing. Shotgun metagenomic sequencing was also performed on 350 samples collected at either 6 weeks or 12 months of age. Among infant participants, 28% were cesarean-delivered (CD) infants and most (95%) initiated breastfeeding within the first six months of life, with 26% exclusively breastfed and 69% mixed-fed (breast milk and formula), in addition to complementary foods by age 1. Alpha (within-sample) diversity was significantly lower in CD infants compared to vaginally delivered (VD) infants (P &lt; 0.05) throughout the study period. Bacterial community composition clustering by both delivery mode and feeding duration at 1 year of age revealed that CD infants who were breast fed for &lt; 6 months were more dissimilar to VD infants than CD infants who breast fed for ≥ 6 months. We observed that breastfeeding modified the longitudinal impact of delivery mode on the taxonomic composition of the microbiota by 1 year of age, with an observed increase in abundance of Bacteroides fragilis and Lactobacillus with longer duration of breastfeeding among CD infants while there was an increase in Faecalibacterium for VD infants. Our findings confirm that duration of breastfeeding plays a critical role in restoring a health-promoting microbiome, call for further investigations regarding the association between breast milk exposure and health outcomes in early life.

scholarly journals Long-chain polyunsaturated fatty acids in breast milk and early weight gain in breast-fed infants

2008 ◽  
Vol 101 (1) ◽  
pp. 116-121 ◽  
Author(s):  
Salome Scholtens ◽  
Alet H. Wijga ◽  
Henriette A. Smit ◽  
Bert Brunekreef ◽  
Johan C. de Jongste ◽  
...  
Keyword(s):  
Weight Gain ◽  
Breast Milk ◽  
Birth Cohort Study ◽  
First Year ◽  
Mite Allergy ◽  
Early Weight Gain ◽  
First Year Of Life ◽  
Lcpufa Content ◽  
Breast Fed ◽  
Long Chain

The long-chain PUFA (LCPUFA) content of an infant's diet might affect early weight gain. In early trials on supplementation of formula feedingn-3 LCPUFA affected weight gain adversely.n-6 LCPUFA are thought to promote adipose tissue development and might be associated with higher weight gain. We studied the association between the naturaln-3 andn-6 LCPUFA content of breast milk of Dutch women and weight and BMI gain of their breast-fed infants in the first year of life. The children in this study were enrolled in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study and were born in 1996–1997 in the Netherlands. Parents reported their child's weight and length in a questionnaire. Of a subgroup of the total population breast-milk samples were collected (n244). The fatty acid composition of breast milk was determined by GLC and expressed as weight percentages. Linear regression was used for data analysis. Mean gain in weight, length and BMI per week from birth to 1 year of age was 119·5 (sd16·1) g, 0·48 (sd0·05) cm and 0·06 (sd0·03) kg/m2, respectively. The associations betweenn-6 andn-3 LCPUFA in breast milk, and infant weight, length and BMI gain were weak and inconsistent. Then-3 andn-6 LCPUFA content in breast milk did not affect weight or BMI gain in the first year of life in breast-fed term infants.

Gastric electrical activity in normal neonates during the first year of life. Effect of lactation with breast milk and formula

2001 ◽  
Vol 120 (5) ◽  
pp. A209-A209
Author(s):  
G RIEZZO ◽  
R CASTELLANA ◽  
T DEBELLIS ◽  
F LAFORGIA ◽  
F INDRIO ◽  
...  
Keyword(s):  
Breast Milk ◽  
Electrical Activity ◽  
First Year ◽  
Gastric Electrical Activity ◽  
First Year Of Life ◽  
Normal Neonates

scholarly journals Effect of breast milk of diabetic mothers on bodyweight of the offspring in the first year of life

2004 ◽  
Vol 58 (10) ◽  
pp. 1429-1431 ◽  
Author(s):  
A Kerssen ◽  
I M Evers ◽  
H W de Valk ◽  
G H A Visser
Keyword(s):  
Breast Milk ◽  
First Year ◽  
First Year Of Life ◽  
Diabetic Mothers

Hospital Maternal Care Is Disruptive

PEDIATRICS ◽  
1976 ◽  
Vol 57 (2) ◽  
pp. 294-295
Author(s):  
Justin D. Call
Keyword(s):  
Breast Milk ◽  
Breast Feeding ◽  
Maternal Care ◽  
Respiratory Infections ◽  
Mammalian Species ◽  
Smooth Transition ◽  
First Year ◽  
First Year Of Life

"Breast-Feeding: Second Thoughts" by Gerrard,1 sets forth epidemiologic and immunological data on human and other mammalian species showing that colostrum and breast milk actively protect the infant from enterocolitis and respiratory infections when breast-feeding is begun immediately after birth and continued through at least most of the first year of life. Gerrard hypothesizes that breast-feeding provides a smooth transition for the baby from being entirely dependent on the mother for nutritional and immunological requirements to being completely independent from her.

scholarly journals Nutritional Status as an Important Factor in the Health Status of the Adult

2017 ◽  
Vol 15 (1-2) ◽  
pp. 19
Author(s):  
J.H.P. Jonxis
Keyword(s):  
Developing Countries ◽  
Health Status ◽  
Fat Metabolism ◽  
Western World ◽  
First Year ◽  
Economic Factors ◽  
Permanent Damage ◽  
The Individual ◽  
First Year Of Life ◽  
Breast Fed

Malnutrition in the first year of life may cause permanent damage to the individual. There may be a permanent retardation in growth if the malnutrition is a serious one and the food intake is severely insufficient over a longer, period. Specially when malnutrition occurs in the first months after birth, it may cause damage to the central nervous system.As long as the breast-fed child gets enough breastmilk, it is unlikely that serious problems  arise. The declinein feeding in many developing countries is a serious problem, especially because the alternatives for human milk are not always available, owing to economic factors. In the, countries of the Western world there exists just, the opposite problem owing to partial over-nutrition abnormalities in fat metabolism may occur, which may influence the health of the individual later on in life.

scholarly journals Safety of potential breast milk exposure to IFN-β or glatiramer acetate

2020 ◽  
Vol 7 (4) ◽  
pp. e757
Author(s):  
Andrea Ines Ciplea ◽  
Annette Langer-Gould ◽  
Anna Stahl ◽  
Sandra Thiel ◽  
Annette Queisser-Wahrendorf ◽  
...  
Keyword(s):  
Breast Milk ◽  
Glatiramer Acetate ◽  
Growth Curves ◽  
Antibiotic Use ◽  
Physical Growth ◽  
First Year ◽  
Motor Delay ◽  
Infant Outcomes ◽  
First Year Of Life

ObjectiveTo determine whether potential breast milk exposure to interferon-beta (IFN-β) or glatiramer acetate (GA) is safe for the infant.MethodsWe identified 74 infants born to 69 women with MS who breastfed under IFN-β (n = 39), GA (n = 34), or both (n = 1). Women had been enrolled into the German Multiple Sclerosis and Pregnancy Registry during pregnancy. Data were obtained from standardized, telephone-administered questionnaires completed by the mother during pregnancy and at 1, 3, 6, and 12 months postpartum and the infant's take-home medical record.ResultsThe median duration of exposed breastfeeding was 8.5 months (wide interquartile range: 4.9–12.7 months). Physical growth curves during the first year of life were consistent with national, sex-specific growth curves. Median body measurements were consistent with national medians. Most children (n = 71, 96%) had normal motor and language development. Gross motor delay was reported in 3 children, of whom 1 remained delayed at last follow-up (3.9 years old) and 2 were normal by 0.9 and 4.1 years old. The proportion of children hospitalized at least once (girls n = 2, 7%, and boys n = 6, 14%) and the proportion of children with at least one episode of systemic antibiotic use during the first year of life (girls n = 7, 23%, and boys n = 8, 18%) are consistent with national averages.ConclusionPotential breast milk exposure to IFN-β or GA did not increase the risk of common adverse infant outcomes in the first year of life. Taken together with the benefits of breastfeeding and low biological plausibility of risk, women with MS who wish to resume IFN-β or GA postpartum can be encouraged to breastfeed.

Hospitalization, Breast-Milk Feeding, and Growth in Infants with Cleft Palate and Cleft Lip and Palate Born in Denmark

2008 ◽  
Vol 45 (6) ◽  
pp. 628-632 ◽  
Author(s):  
Lisa H. V. Smedegaard ◽  
Dorthe R. N. Marxen ◽  
Jette H. V. Moes ◽  
Eva N. Glassou ◽  
Cand Scientsan
Keyword(s):  
Breast Milk ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
First Year ◽  
Health Visitors ◽  
Facial Clefts ◽  
Growth References ◽  
First Year Of Life ◽  
Milk Feeding

Objective: To evaluate if the duration of postpartum hospitalization, duration of breast-milk feeding, and growth during the first year of life in infants with cleft lip and palate (CLP) and cleft palate (CP) are comparable to infants without facial clefts. Design: Prospective data collection using a registration chart developed by the authors. Setting: Special health care of infants with CLP/CP born in Denmark. Participants: All mature infants with CLP/CP born in 2003 and 2004 were included. Of 165 infants, 115 participated in the study. Intervention: In Denmark, parents of children with CLP/CP receive counseling. This counseling is managed by specially trained health visitors/nurses and is initiated at birth. The counseling seeks to support parents’ confidence in having an infant with CLP/CP and to initiate a relationship between the infant and the parents. Main Outcome Measures: Duration of postpartum hospitalization, duration of breast-milk feeding, and weight and length at birth, 5 months of age, and 12 months of age. Results: Hospitalization was 4 days and comparable to that of infants without CLP/CP. The infants with CLP/CP received breast milk but for a shorter period compared with infants without CLP/CP. Weights at birth, 5 months of age, and 12 months of age were identical with Danish growth references. Conclusion: The authors find the results satisfactory and believe that the counseling provided by the health visitors/nurses plays a part in the results.

scholarly journals Variation in the Protein Composition of Human Milk during Extended Lactation: A Narrative Review

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1124 ◽  
Author(s):  
Sergio Verd ◽  
Gemma Ginovart ◽  
Javier Calvo ◽  
Jaume Ponce-Taylor ◽  
Antoni Gaya
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Protein Content ◽  
Milk Protein ◽  
Mammalian Species ◽  
Protein Composition ◽  
Developed Countries ◽  
First Year ◽  
Second Year ◽  
First Year Of Life

The aim of this review is to evaluate changes in protein parameters in the second year postpartum. There is considerable agreement among authors about the declining trend of human milk protein concentrations, but most research on protein content in breast milk focuses on the first year of life and comes from developed countries. Whereas this is the case for exclusive breastfeeding or for breastfeeding into the first year of life, the opposite applies to weaning or extended breastfeeding. This review is predominantly based on observational epidemiological evidence and on comparative research linking breast milk composition with cutting down on breastfeeding. Studies dating back several decades have shown an increase in the proportion of immunoglobulins, lactoferrin, and serum albumin during weaning. According to the limited data available, it seems likely that the regulation of milk protein composition during involution can be ascribed to alterations in tight junctions. In studies on humans and other mammalian species, offspring suckle more from mothers that produce more dilute milk and the increase in milk protein concentration is positively correlated to a decrease in suckling frequency during weaning. High milk protein contents were first reported in nonindustrial communities where breastfeeding is sustained the longest, but recent papers from urbanized communities have taken credit for rediscovering the increase in protein content of human milk that becomes evident with prolonged breastfeeding. This review presents an overview of the changes in breast milk protein parameters in the second year postpartum to enable milk banks’ practitioners to make informed nutritional decisions on preterm infants.

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