scholarly journals Modern opportunities for optimising the treatment of patients with coronary heart disease and arterial hypertension: role of zofenopril

2012 ◽  
Vol 11 (4) ◽  
pp. 85-92
Author(s):  
A. G. Evdokimova ◽  
V. V. Evdokimov ◽  
N. V. Leonenko ◽  
A. V. Smetanin

The wide prevalence (82%) of coronary heart disease (CHD) in combination with arterial hypertension (AH), as well as its initiating role in the development of fatal complications, such as myocardial infarction (MI) or heart failure, emphasise the need for the choice of optimal ACE inhibitors with organ-protective characteristics. This paper presents a literature review on the effectiveness of a SH-containing ACE inhibitor zofenopril in patients with CHD and AH, in terms of its anti-anginal and antihypertensive activity. The authors summarise the results of the international SMILE studies which included patients after acute MI. It was demonstrated that zofenopril therapy is associated with reduced combined incidence of cardiovascular death or cardiovascular hospitalisation, and is also safe in the acute post-MI period. In patients with preserved left ventricular function, zofenopril reduced the incidence of angina attacks and arrhythmias of coronary genesis, as well as improved exercise capacity. A clinical case of zofenopril therapy, as a part of a complex treatment regimen, is also presented.

2012 ◽  
Vol 11 (6) ◽  
pp. 78-80
Author(s):  
E. O. Taratukhin

The paper considers arterial hypertension and coronary heart disease as pathologies which share multiple pathogenetic mechanisms. The role of angiotensin II receptor antagonists (ARA) in the effective treatment of these diseases and in prevention of their complications is discussed. The modern views on ARA and their indications are presented.


2019 ◽  
Vol 37 ◽  
pp. e217-e218
Author(s):  
T. Yaneva-Sirakova ◽  
R. Kaneva ◽  
R. Bozhilova ◽  
I. Popov ◽  
R. Tzveova ◽  
...  

2014 ◽  
Vol 11 (1) ◽  
pp. 73-77
Author(s):  
D I Trukhan ◽  
L V Tarasova

Important problem for the cardiologist and the first contact a doctor (therapist and general practitioner) is to optimize the therapeutic and preventive aspects of drug therapy in patients with coronary heart disease and arterial hypertension. The article considers the question of choice of ACE inhibitor from the standpoint of rational pharmacotherapy and evidence-based medicine.


Author(s):  
M. L. Rudenko ◽  
N. O. Ioffe ◽  
V. V. Vayda ◽  
A. A. Pavlykova-Chertovska

The current problem of modern medicine is the lack of public awareness about personal health, late diagnosis of diseases, untimely prehospital care and treatment of existing complications. This applies to all branches of medicine, especially cardiology and cardiac surgery. Coronary heart disease occupies one of the leading places in the structure of mortality due to cardiovascular diseases. This is mainly due to the fact that patients seek medical care with complicated forms of coronary heart disease like sudden cardiac death, cardiac arrhythmia (ventricular fibrillation, AV blockade, sinus bradycardia and tachycardia), formation of left ventricular (LV) aneurysm, LV free wall rupture and LV false aneurysm, mitral regurgitation. In such cases, all actions must be early, staged, well established, and concordant with clear algorithm. The aim. To demonstrate our clinical case as an example of proper logistics, rapid response and timely surgical treatment of complicated forms of coronary heart disease. Clinical case. Patient F., born in 1964, was admitted to the clinic on March 24, 2021 with a diagnosis of coronary heart disease: acute non-Q-wave myocardial infarction of the posterolateral LV since March 22, 2021. Clinical death with successful resuscitation at the prehospital stage (03/22/2021). Ventricular fibrillation (03/22/2021). Multivessel coronary artery disease. Mitral valve regurgitation grade II-III. Tricuspid valve regurgitation grade I-II. Pulmonary hypertension grade I. Hypertensive disease grade III, degree 3, risk 4 (very high). Heart failure II A with a moderately reduced LV ejection fraction (47%). NYHA3. Closed chest injury (03/22/2021): fracture of the ribs without displacement: ribs 4-8 on the left, ribs 4-8 on the right. He considers himself ill since March 22, 2021, when he suddenly felt severe pain in his chest and fell unconscious. According to witnesses, the man got out of the subway and fell unconscious, without breathing and pulse. Due to the presence of defibrillators at the subway station, successful resuscitation was conducted by police officers before the ambulance crew arrival. Clinical and instrumental studies were performed after hospitalization. The patient was taken to the operating room on 03/24/2021 at 5:30 PM, 50 minutes after admission to the National Amosov Institute, Kyiv. Urgent off-pump coronary artery bypass grafting of 3 coronary arteries was performed. A cardioverter-defibrillator was implanted due to the history of clinical death and the conclusion of daily ECG monitoring. The intra- and postoperative period was uneventful, the patient was discharged in satisfactory condition for rehabilitation. Conclusions. Our clinical experience shows that timely prehospital care, proper logistics and surgical correction of coronary heart disease not only saves but also significantly improves the quality of life of the patient in the future.


2003 ◽  
Vol 9 (4) ◽  
pp. 124-127 ◽  
Author(s):  
A. A. Kozina ◽  
Yu. A. Vasyuk ◽  
Yc. N. Yushchuk ◽  
Ye. A. Nesterova ◽  
LA. .. Sadulayeva

Sixty five patients (mean age 55.7 ± 8,7 years), including 51 patients with arterial hypertension (AH) (mean age 54,9 ± 8,6 years) and 14 patients with a combination of AG and coronary heart disease (CHD) with postinfarction cardiosclerosis (mean age 54,9 ± 8,6 years) were examined. According to the values of average daily blood pressure variability (HPV), the patients were divided into subgroups with normal (11 patients with AH and 3 patients with AH and CHD) and increased (39 patients with AH and 12 patients with AH and CUD) BPV. Patients with isolated AH were found to have developed concentric hypertrophy of the left ventricle (LV), and moderate LV diastolic dysfunction mainly with impaired relaxation and the patients with a combination of AH and CHD with postinfarction cardiosclerosis had more significant LV structural and geometric derangements with a tendency for the development of eccentric hypertrophy of the LV, as well as more marked diastolic dysfunction with a larger proportion of the pseudo-normal and restrictive types of LV diastolic function. Patients with increased average daily BPV were found to have more significant LV structural, geometrical, and diastolic impairments.


2004 ◽  
Vol 10 (3) ◽  
pp. 155-158
Author(s):  
N. F. Plavunov ◽  
V. V. Stepanova ◽  
Yu. L. Karaulova ◽  
Yn. V. Kotovskaya ◽  
Zh. .. Kobalava ◽  
...  

The role of arterial hypertension (AH) in the pattern and outcomes of hospitalizations at a multidisciplinary emergency care hospital was analyzed, by using annual statistical reports and 0199 statistical cards on patients with AH, admitted to the therapeutic, cardiological, and neurological units of City Clinical Hospital No. 64 in 2000-2001. The bulk of patients with AH comprised above 60-year-old individuals having complications and concomitant diseases (most commonly coronary heart disease, diabetes mellitus, obesity, chronic bronchi!is). AH was the background disease in most patients admitted to the hospital for myocardial infarction and acute cerebral circulatory disorders, There arc great differences in the incidence of AH, as evidenced by annual final statistical reports (3.6 %) and individual Statistical forms (23.4 %), which leads to the underestimation of the actual prevalence of AG in inpatient practice.


Sign in / Sign up

Export Citation Format

Share Document