scholarly journals Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats

2016 ◽  
Vol 49 (9) ◽  
Author(s):  
P.R. Lopes ◽  
M.C.S. Moreira ◽  
S.M. Marques ◽  
I.S.J. Pinto ◽  
L.M. Macedo ◽  
...  
Keyword(s):  
Exercise Training ◽  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Baroreflex Sensitivity ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Angiotensin Converting Enzyme 2

scholarly journals Gene transfer of angiotensin-converting enzyme 2 in the nucleus tractus solitarius improves baroreceptor heart rate reflex in spontaneously hypertensive rats

2011 ◽  
Vol 12 (4) ◽  
pp. 456-461 ◽  
Author(s):  
Masanobu Yamazato ◽  
Anderson J Ferreira ◽  
Yoriko Yamazato ◽  
Carlos Diez-Freire ◽  
Lihui Yuan ◽  
...  
Keyword(s):  
Heart Rate ◽  
Gene Transfer ◽  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Nucleus Tractus Solitarius ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Angiotensin Converting Enzyme 2 ◽  
Ace2 Gene

The renin–angiotensin system (RAS) in the nucleus tractus solitarius (NTS) is an important modulator of the baroreceptor heart rate reflex. This study tested the hypothesis that angiotensin-converting enzyme 2 (ACE2) expression is decreased in the NTS of spontaneously hypertensive rats (SHRs) and that its gene transfer in this nucleus would lead to beneficial effects on baroreflex function since this enzyme is key in the regulation of the vasoprotective axis of the RAS. ACE2 protein levels and its activity were significantly decreased in the NTS of SHRs compared to normotensive Wistar-Kyoto (WKY) control rats. Rats instrumented with radio-telemetry transducers received NTS microinjection of either Lenti-ACE2 (Lentiviral vector-mediated gene transfer of ACE2) or lenti-GFP (green fluorescent protein). The ACE2 gene transfer into the NTS resulted in long-term overexpression of ACE2. This was associated with a 60% increase in heart rate baroreflex sensitivity in the lenti-ACE2 injected SHRs compared with the lenti-GFP injected control SHRs (0.27 ± 0.02 ms/mmHg in lenti-GFP rats vs. 0.44 ± 0.07 ms/mmHg in lenti-ACE2 rats). These observations demonstrate that ACE2 gene transfer overcomes its intrinsic decrease in the NTS of SHRs and improves baroreceptor heart rate reflex.

Cardiomyocyte Apoptosis and Cardiac Angiotensin-Converting Enzyme in Spontaneously Hypertensive Rats

Hypertension ◽  
1997 ◽  
Vol 30 (5) ◽  
pp. 1029-1034 ◽  
Author(s):  
Javier Díez ◽  
Angel Panizo ◽  
Marta Hernández ◽  
Francisco Vega ◽  
Iosu Sola ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Cardiomyocyte Apoptosis ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
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