EFFECTS OF AEROBIC TRAINING ON THE CARDIOMYOCYTES OF THE RIGHT ATRIUM OF MICE

ABSTRACT Introduction: Polypeptide hormones (natriuretic peptides, NPs) are secreted by the cardiac atria and play an important role in the regulation of blood pressure. Objective: To evaluate the effects of aerobic training on the secretory apparatus of NPs in cardiomyocytes of the right atrium. Methods: Nine-month-old mice were divided in two groups (n=10): control group (CG) and trained group (TG). The training protocol was performed on a motor treadmill for 8 weeks. Systolic blood pressure was measured at the beginning of the experiment (9 months of age) and at moment of the sacrifice (11 months of age). Electron micrographs were used to quantify the following variables: the quantitative density and area of NP granules, the relative volumes of the mitochondria, endoplasmic reticulum, and Golgi complex and the relative volume of euchromatin in the nucleus and the number of pores per 10 µm of the nuclear membrane. The results were compared by Student's t test (p< 0.05). Results: The cardiomyocytes obtained from TG mice showed increased density and sectional area of secretory granules of NP, higher relative volume of endoplasmic reticulum, mitochondria, and Golgi complex compared with the CG mice. Furthermore, the quantitative density of nuclear pores and the relative volume of euchromatin in the nucleus were significantly higher compared with the CG mice. Conclusion: Aerobic training caused hypertrophy of the secretory apparatus in the cardiomyocytes of right atrium, which could explain the intense synthesis of natriuretic peptides in trained mice with respect to the untrained mice.

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Changes of electrophysiological parameters in patients with atrial flutter

Medicina ◽

10.3390/medicina43080078 ◽

2007 ◽

Vol 43 (8) ◽

pp. 614 ◽

Cited By ~ 1

Author(s):

Diana Žaliaduonytė-Pekšienė ◽

Tomas Kazakevičius ◽

Vytautas Zabiela ◽

Vytautas Šileikis ◽

Remigijus Vaičiulis ◽

...

Keyword(s):

Response Time ◽

Atrial Flutter ◽

Right Atrium ◽

Propagation Speed ◽

Control Group ◽

Type I ◽

Stimulus Response ◽

Refractory Periods ◽

Impulse Propagation ◽

The Right

Objectives. The aim of the study was to study some anatomic and electrophysiological features of the right atrium, related to the presence of atrial flutter. Materials and methods. A total 23 patients with type I atrial flutter and 22 patients without atrial flutter were studied. Right atrium size was assessed using echocardiography before intracardiac examination and radiofrequency ablation. Results. Effective refractory periods of coronary sinus, high right atrium, low right atrium were different comparing with the control group (P<0.05). A stimulus–response time between high right atrium and low right atrium positions in anterograde and retrograde ways, an impulse propagation speed along the lateral wall of the right atrium were statistically different comparing both groups (P<0.05). There was a significant correlation among effective refractory periods measured in different sites of the right atrium (r²=0.64, 0.44, 0.44, respectively). All measured effective refractory periods also correlated with stimulus–response time in anterograde way (P<0.05) and impulse propagation speed (P<0.05). Right atrium dimensions were significantly larger in atrial flutter group. There was no correlation between the right atrium dimensions and measured electrophysiological parameters in both groups.Conclusions. The presence of atrial flutter associates with diffuse alterations of the right atrium, but not the focal or single changes of refractoriness.

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Spectral Analysis of Heart Rate Variability during Trigger Point Acupuncture

Acupuncture in Medicine ◽

10.1136/acupmed-2013-010440 ◽

2014 ◽

Vol 32 (3) ◽

pp. 273-278 ◽

Cited By ~ 10

Author(s):

Yoji Kitagawa ◽

Kenichi Kimura ◽

Sohei Yoshida

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Heart Rate Variability ◽

Spectral Analysis ◽

Tibialis Anterior ◽

Trigger Point ◽

Tibialis Anterior Muscle ◽

Trigger Points ◽

Control Group ◽

The Right

Objectives To clarify changes in the cardiovascular autonomic nervous system function due to trigger point acupuncture, we evaluated differences in responses between acupuncture at trigger points and those at other sites using spectral analysis of heart rate variability. Methods Subjects were 35 healthy men. Before measurements began the subjects were assigned to a trigger point acupuncture or control group based on the presence/absence of referred pain on applying pressure to a taut band within the right tibialis anterior muscle. The measurements were conducted in a room with a temperature of 25°C, with subjects in a long sitting position after 10 min rest. Acupuncture needles were retained for 10 min at two sites on the right tibialis anterior muscle. ECG was performed simultaneously with measurements of blood pressure and the respiratory cycle. Based on the R–R interval on the ECG, frequency analysis was performed, low-frequency (LF) and high-frequency (HF) components were extracted and the ratio of LF to HF components (LF/HF) was evaluated. Results The trigger point acupuncture group showed a transient decrease in heart rate and an increase in the HF component but no significant changes in LF/HF. In the control group, no significant changes were observed in heart rate, the HF component or LF/HF. There were no consistent changes in systolic or diastolic blood pressure in either group. Conclusions These data suggest that acupuncture stimulation of trigger points of the tibialis anterior muscle transiently increases parasympathetic nerve activity.

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Atrial function after treatment of atrial septal defects in children under 5 years

10.21203/rs.3.rs-16328/v1 ◽

2020 ◽

Author(s):

Eun-Young Choi ◽

Eun Sun Kim ◽

Jung-Yoon Kim ◽

Su-Jin Park ◽

Ja-kyoung Yoon ◽

...

Keyword(s):

Right Atrium ◽

Global Longitudinal Strain ◽

Atrial Function ◽

Right Atrial ◽

Control Group ◽

Closure Device ◽

Right Atrial Function ◽

One Year ◽

Asd Closure ◽

The Right

Abstract BackgroundRecently, the patient’s age of atrial septal defect (ASD) treatment has been gradually decreasing. However, the most appropriate age and treatment method remain controversial. We hypothesized that treatment of ASDs in patients under 5 years would be able to adequately normalize bi-atrial function over one year after treatment. The purpose of this study is to confirm the normalization of hypothesized atrial function.MethodsData of fifteen patients who underwent surgical ASD closure under 5 years of age (Operation group), 15 patients who underwent percutaneous ASD closure (Device group), and 15 age- and gender-matched normal control patients (Control group) were extracted from our echocardiographic data. Conventional 2D images and 2D speckle tracking method were used to evaluate bi-atrial function.ResultsLeft atrial function, εS, εE, and εA showed no significant differences in the three groups. Indicators representing the right atrial function varied with the three groups. However, there were no significant differences in the global longitudinal strain of the right atrium between the Operation and Device groups.ConclusionsAfter ASD treatment, right atrial function recovery is less than that of the left atrium. The function of the right atrium is not normalized after more than one year of treatment for ASD in patients under 5 years. After ASD treatment, further follow-up of the bi-atrial function is necessary.

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Effects of Aerobic Training Progression on Blood Pressure in Individuals With Hypertension: A Systematic Review With Meta-Analysis and Meta-Regression

10.21203/rs.3.rs-156120/v1 ◽

2021 ◽

Author(s):

Guilherme Tadeu de Barcelos¹ ◽

Isabel Heberle¹ ◽

Juliana Cavestré Coneglian¹ ◽

Bruno Allan Vieira¹ ◽

Rodrigo Sudatti Delevatti¹ ◽

...

Keyword(s):

Systematic Review ◽

Blood Pressure ◽

Clinical Trials ◽

Systolic Blood Pressure ◽

Aerobic Training ◽

Data Extraction ◽

Meta Analysis ◽

Control Group ◽

Meta Regression ◽

Selection Of

Abstract Objective: To analyze, through a systematic review with meta-analysis, the effects of aerobic training with and without progression on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in hypertensive adults.Method: The search for the studies was carried out in the PubMed, Cochrane Central, SPORTDiscus and LILACS databases. Clinical trials that analyzed the effect of aerobic training, lasting at least six weeks, on blood pressure in hypertensive individuals comparing with a control group without intervention were selected. The selection of studies and data extraction were carried out independently by two pairs of researchers. Results: Of the 13028 studies found, 24 were selected and included in this review. There was a reduction in SBP after aerobic training with progression (-10.67 mmHg; 95% CI -15.421, -5.926; p <0.001) and without progression (-10.17 mmHg; CI -12.213, -8.120; p <0.001). DBP also decreased after aerobic training with progression (-5.49 mmHg; 95% CI -8.663, -2.310; p <0.001) and without progression (-6.51 mmHg; 95% CI -9.147, -3.868; p < 0.001). Conclusion: Aerobic training promotes a reduction in the SBP and DBP levels of adults with hypertension, regardless of whether or not the training variables progression.

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A Novel Wire Is Effective for Echo-Guiding Percutaneous Atrial Septal Defect Closure: A Preclinical Study

Journal of Healthcare Engineering ◽

10.1155/2018/5784567 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Yao Liu ◽

Gai-Li Guo ◽

Feng-Wen Zhang ◽

Bin Wen ◽

Wen-Bin Ou-Yang ◽

...

Keyword(s):

Atrial Septal Defect ◽

Right Atrium ◽

Septal Defect ◽

Guide Wire ◽

Control Group ◽

Study Group ◽

Atrial Septal Defect Closure ◽

Sheep Model ◽

Asd Closure ◽

The Right

Objective. To assess the effectiveness of a novel ultrasound wire for echo-guiding percutaneous atrial septal defect (ASD) closure in a sheep model. Methods. After right lateral thoracotomy, ASDs were created in 20 sheep by transseptal needle puncture followed by balloon dilatation. Animals were evenly randomized into 2 groups to undergo ASD closure using echography as the only imaging tool with either COOK wire (control group) or new ultrasound wire (study group). The total procedural time, passing time (time needed for the guide wire to enter the left atrium), frequency of delivery sheath dropping into the right atrium, frequency of arrhythmias, and 1-week rate of complications were compared between the two groups. Results. All animals survived defect creation procedures uneventfully. ASD devices were successfully implanted in all sheep. Compared with the control group, the study group had significantly (P<0.05) lower mean procedure time (15.36 ± 4.86 versus 25.82 ± 7.85 min), lower mean passing time (2.69 ± 0.82 versus 5.58 ± 3.34 min), lower frequency of the guide wire dropping into the right atrium (0% versus 40%), and lower frequency of atrial (4.41 ± 2.61 versus 9.60 ± 3.68) or ventricular premature contractions (0.75 ± 0.36 versus 1.34 ± 0.68), respectively, without serious complications up to one week. Conclusion. The novel ultrasound specialized guide wire was effective in echo-guiding percutaneous ASD closure.

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“The Way to a Man’s Heart” - Adrenocortical Carcinoma With Vascular Invasion Into the Right Atrium and Ventricle

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.2012 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A983-A984

Author(s):

Hassaan B Aftab ◽

Kaye-Anne L Newton ◽

Vitaly Kantorovich

Keyword(s):

Blood Pressure ◽

Adrenal Gland ◽

Inferior Vena Cava ◽

Right Atrium ◽

Adrenal Mass ◽

Inferior Vena ◽

Vena Cava ◽

History Of ◽

The Right ◽

Right Hepatic Vein

Abstract Background: Adrenocortical carcinoma (ACC) is a rare aggressive malignant neoplasm which may present with intravascular extension into the inferior vena cava (IVC) and rarely into the right atrium (RA). Clinical Case: 62-year-old male with no prior known significant medical history presented to ED with 2-day history of mild hematuria with 3-week history of headache. Vital signs were normal other than blood pressure of 198/88 while physical exam was unremarkable. Headache subsided and blood pressure improved to 130/60 range after IV labetalol administration. CT abdomen and pelvis with contrast revealed a large right suprarenal mass extending into the right hepatic vein, IVC, and RA. The right adrenal gland was not visualized while the left adrenal gland and bilateral kidneys were normal. MRI chest, heart and abdomen with contrast showed heterogeneously enhancing lobulated right adrenal mass measuring 11.4 x 11 x 14 cm (AP, transverse, CC, respectively) with extensive tumor thrombus invading the right hepatic vein, IVC, RA and notably protruding into the right ventricle (RV) through the tricuspid valve during diastole. Technitium-99m MDP whole body scan did not show any uptake suspicious for metastases. Pre-op lab assessment showed mildly abnormal 1 mg dexamethasone suppression test but no evidence of ACTH suppression, elevated catecholamines or excess adrenal steroidogenesis. He underwent combined cardiothoracic and abdominal surgery on cardiopulmonary bypass with resection of adrenal mass, removal of thrombus from IVC, RA, RV and patch angioplasty of IVC with bovine pericardium. Pathology report was consistent with ACC (AJCC stage III). On 1 month postoperative follow-up, patient is clinically doing well with plans to start mitotane with addition of etoposide/doxorubicin/cisplatin (EDP) chemotherapy. Conclusion: ACC is a rare, highly aggressive malignancy which may produce extensive intravascular invasion. It may rarely extend to the RA and even rarer into the RV; with 42 and 1 reported cases, respectively. No study has conclusively found that vascular extension of ACC is a poor prognostic factor, hence surgical management is the primary strategy including cases with RA/RV involvement. There is lack of data and consensus regarding adjuvant or palliative medical therapy. However, in phase II trials combination of EDP chemotherapy and mitotane have shown response rates ranging from 11% to 54%. Reference: Alghulayqah, Abdulaziz, et al. “Long-term recurrence-free survival of adrenocortical cancer extending into the inferior vena cava and right atrium: Case report and literature review.” Medicine 96.18 (2017).

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Comparison of Intraocular Pressure among Individuals with Systemic Hypertension and those with Normal Blood Pressure

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v13i2.33917 ◽

2021 ◽

Vol 13 (2) ◽

pp. 137-144

Author(s):

Sanket Parajuli ◽

Pooja Shrestha ◽

Jeevan K Shrestha ◽

Sadhana Sharma

Keyword(s):

Blood Pressure ◽

Intraocular Pressure ◽

Normal Blood ◽

Systemic Hypertension ◽

Control Group ◽

Case Group ◽

Normal Blood Pressure ◽

Hypertensive Group ◽

Significant Difference ◽

The Right

Introduction: Systemic blood pressure, by far, is one of the most important factors that can have an effect on intraocular pressure. We have compared the intraocular pressure (IOP) among patients with systemic hypertension and those with normal blood pressure. Materials and methods: A hospital based case control study was conducted from March 2017 to March 2018 in the Ophthalmology outpatient department at Dhulikhel Hospital. A total of 100 patients with hypertension were included in the case group (hypertensive group) and 100 cases with no systemic or ocular disease were included in the control group (normotensive group). Mean intraocular pressures were calculated and compared between the two groups. Results: Mean age of patients was 49.03 years in hypertensive group and 47.53 years in normotensive group. Mean IOP of the right eye in those with hypertension was 16.10 mmHg and in the left eye was 15.8 mmHg. Similarly mean IOP of the right eye in the normotensive group was 15.8 mmHg and the left eye was 16.2 mmHg. The difference between mean IOP of hypertensive and normotensive individuals was not statistically significant (p > 0.05). The prevalence of ocular hypertension was found to be 7.5%. Conclusion: There was no statistically significant difference in IOP between hypertensive and normotensive individuals. However, a statistically significant difference in IOP was noted between ‘hypertensive with controlled blood pressure’ and ‘hypertensive with uncontrolled BP’ indicating that high blood pressure may be associated with high IOP.

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NON-MEDICAMENTAL METHODS OF REHABILITATION POWER ATHLETES WITH ARTERIAL HYPERTENSION: RANDOMIZED CONTROLLED INVESTIGATION

Aerospace and Environmental Medicine ◽

10.21687/0233-528x-2021-55-2-77-83 ◽

2021 ◽

Vol 55 (2) ◽

pp. 77-83

Author(s):

A.B. Miroshnikov ◽

◽

V.I. Shmyrev ◽

I.E. Kalenova ◽

◽

...

Keyword(s):

Blood Pressure ◽

High Intensity ◽

Aerobic Training ◽

Blood Pressure Measurement ◽

Interval Training ◽

Bicycle Ergometer ◽

Quadriceps Femoris ◽

Physical Rehabilitation ◽

Control Group ◽

High Intensity Interval

The paper discusses the effects of high intensity interval aerobic training on blood pressure, body composition, oxidative ability and muscle strength in strength-power athletes of different weight classes. Subjects of examination and physical rehabilitation were 55 hypertensive heavy-weight athletes of comparable age and clinical findings who were randomized into the main (n = 35) and control (n = 20) groups. The main group trained 120 days (3 sessions per a week) on a bicycle ergometer following a high intensity interval; the control group trained in parallel but following the traditional strength developing protocol. Before and on completion of the physical rehabilitation, the sportsmen were interviewed and underwent medical examination including a triple blood pressure measurement, bioimpedometry, ergospirometry, body index calculation, and the test for maximal voluntary strength of m. quadriceps femoris. The rehabilitation improved bioimpedometry parameters, reduced blood pressure noticeably (systolic BP by 4.7 % and diastolic BP by 5.6 %), increased oxygen consumption and quadriceps femoris strength. Investigations showed that the high intensity interval training has a medioprophylactic effect on the cardiovascular system. The authors developed an aerobic training protocol for safe and successful hypertension prophylaxis and therapy in athletes.

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The cardiovascular system in patients with functional and inflammatory bowel diseases

Terapevticheskii arkhiv ◽

10.26442/terarkh201890259-64 ◽

2018 ◽

Vol 90 (2) ◽

pp. 59-64

Author(s):

I V Maev ◽

A N Kazulin ◽

D N Andreev

Keyword(s):

Right Ventricle ◽

Cardiovascular System ◽

Inflammatory Bowel Diseases ◽

Right Atrium ◽

Systolic Pressure ◽

Clinical Manifestations ◽

Control Group ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

The Right

Aim. Identification of subclinical and metamanifests state changes of cardiovascular system in patients with functional and inflammatory bowel diseases (IBD) without a background of cardiac pathology. Materials and methods. Was examined 79 patients with colon diseases, 20 patients were diagnosed with irritable bowel syndrome (IBS) with diarrhea, 37 - with undifferentiated colitis (UdC) and 22 patients with ulcerative colitis (UC). As a control group were examined in 50 healthy subjects. All patients received treatment in accordance with international and national guidelines. Prescribed medications had effect on the function of the cardiovascular system. Patients with contacting the hospital and against the onset of remission was performed ultrasound of the heart. Determines the size of the left atrium, heart rate, end-diastolic volume, end-systolic volume, ejection fraction (EF), cardiac index (CI), total peripheral vascular resistance, the presence of right heart failure, blood flow, the area of the right atrium and right ventricle in systole and diastole, and calculated the proportion of contractility of the right atrium and right ventricle. Determined systolic pressure in PA (SPPA), the average pressure in PA (APPA). Results. Clinical manifestations of cardiac syndrome was identified in 75,0% of patients with IBS, 54,1% of patients NK and 68,2% patients with UC. When performing correlation analysis in the patients with UdC and UC was noted the relationship of hemodynamic parameters and disease severity was more pronounced in UC. So, when comparing the duration of the disease and levels of the MLC - r=0,52 and r=0,73 (p

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The Effects of 8-Week Aerobic Training Program on Respiratory and Circulatory Parameters of Female Swimmers Between 12-14 Years Old

Journal of Education and Training Studies ◽

10.11114/jets.v6i12.3745 ◽

2018 ◽

Vol 6 (12) ◽

pp. 202 ◽

Cited By ~ 1

Author(s):

Meltem Kilicaslan Kalkan ◽

Onder Daglioglu

Keyword(s):

Blood Pressure ◽

Training Program ◽

Vital Capacity ◽

Aerobic Training ◽

T Test ◽

Control Group ◽

Respiratory Parameters ◽

Significant Difference ◽

Experimental Group ◽

Group Comparisons

The purpose of this study is to investigate the effect of 8-week aerobic training program on respiratory and circulatory parameters in female swimmers between 12-14 years old. A total of 22 female swimmers, who were between 12-14 years old and joined to the national competitions in the province of Gaziantep, participated as volunteers. The subjects were randomly divided into two groups as experimental group (n=11, age:13.12±0.69) and control group (n=11, age:12.56±0.53). Aerobic training program was applied to the experimental group 3 days a week for 8 weeks. Both groups continued their regular swimming trainings. Resting heart rate (RHR), systolic blood pressure (SBP), diastolic blood pressure (DBP) measurements of the subjects were performed as circulatory parameters before and after training. These values were measured by Omron M6 Comfort device. Measurements of vital capacity (VC), forced vital capacity (FVC), forced expiratory volume (FEV1) and forced expiratory rate (FEV1/FVC) were performed as respiratory parameters. These values were measured by M.E.C. Pocket Spiro USB-100 instruments. For statistical analysis of data, Paired Sample t test was used for intra-group comparisons, and the Independent Sample t test was used for inter-group comparisons. The level of significance was determined as p<0.05. In the study we performed, the values of RHR, SBP, DBP, VC, FVC, FEV1 and FEV1/FVC were found to be significant after the aerobic training program applied to the experimental group (p<0.05). The circulatory parameters of the control group showed significance at p<0.05 level in RHR value. There was no significant difference between SBP and DBP values (p>0.05). The respiratory parameters of the control group were significant in FVC and FEV1 values (p<0.05). There was no significant difference between VC and FEV1/FVC values (p>0.05). As a result, it is thought that aerobic trainings have positive effects on respiratory and circulatory parameters in swimmers. It can be said that regular aerobic training improves respiratory and circulatory parameters.

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