scholarly journals Refractory pemphigus vulgaris associated with herpes infection: case report and review

2011 ◽  
Vol 53 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Maria Luiza Figueiredo Braga Brandão ◽  
Nurimar C. Fernandes ◽  
Danielle Pereira De Oliveira Batista ◽  
Norma Santos
Keyword(s):  
Sequence Analysis ◽  
Pemphigus Vulgaris ◽  
Chain Reaction ◽  
Upper Eyelid ◽  
Triggering Factor ◽  
Polymerase Chain ◽  
Genetic And Environmental Factors ◽  
The Right ◽  
Hsv 1

BACKGROUND: Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering of the skin and mucosa, which develops due to the interaction between predisposing genetic and environmental factors. Infections caused by members of the Herpesviridae family have been suggested as a possible triggering factor for PV. OBJECTIVE AND METHODS: In this report, we investigate the presence of herpesviruses in refractory lesions on the right upper eyelid. The lesion has persisted despite the treatment with corticosteroids. Polymerase chain reaction (PCR) and DNA sequence analysis have been used to detect the DNA of HSV 1/2, VZV, EBV, CMV, HHV-6, HHV-7, and HHV-8. RESULTS: The sample collected from the right upper eyelid has tested positive for HSV 1/2. Sequence analysis has confirmed the PCR results and allowed the identification of the HSV strain as belonging to type 1. After treatment with acyclovir, the lesion of the right upper eyelid has cleared and not relapsed. CONCLUSION: When patients present PV lesions which are refractory to corticosteroid therapy, herpetic infection should be considered.

scholarly journals Disseminated Herpes Simplex Virus Type 1 Primary Infection in a Healthy Individual

2009 ◽  
Vol 20 (4) ◽  
pp. 122-125 ◽  
Author(s):  
Guy Boivin ◽  
Brigitte Malette ◽  
Nathalie Goyette
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Primary Infection ◽  
Polymerase Chain Reaction Detection ◽  
Chain Reaction ◽  
Detection Techniques ◽  
Polymerase Chain ◽  
Simplex Virus ◽  
Hsv 1

BACKGROUND: Primary herpes simplex virus (HSV) infection usually involves one mucosal region.OBJECTIVE: To describe an unusual disseminated HSV-1 infection involving two mucosal sites in a healthy man.RESULTS: Primary HSV infection involved oral and genital mucosa and was associated with viremia, hepatitis and rash. Phylogenetic analysis of genital and oral viruses revealed that the patient was infected by a single HSV-1 strain.CONCLUSION: Use of polymerase chain reaction detection techniques for HSV may identify viremic patients in the absence of obvious immunosuppression.

A polymerase chain reaction-based approach in search of potential T cell epitopes in pemphigus vulgaris

1998 ◽  
Vol 16 ◽  
pp. S42
Author(s):  
Animesh A. Sinha ◽  
Mark Shlyankevich ◽  
Mong-Shang Lin ◽  
Luis A. Diaz ◽  
Robert E. Tigelaar ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
T Cell ◽  
Pemphigus Vulgaris ◽  
T Cell Epitopes ◽  
Chain Reaction ◽  
Polymerase Chain

scholarly journals Adult gonococcal keratoconjunctivitis: early detection is key

2020 ◽  
Vol 17 (1) ◽  
pp. 30-34
Author(s):  
Daniel Lai ◽  
Keith Ong
Keyword(s):  
Polymerase Chain Reaction ◽  
Early Detection ◽  
Neisseria Gonorrhoeae ◽  
Ophthalmic Solution ◽  
Careful Monitoring ◽  
Corneal Ulceration ◽  
Chain Reaction ◽  
Bacterial Conjunctivitis ◽  
Polymerase Chain ◽  
The Right

We describe a case of a 52-year-old male presenting with severe mucopurulent conjunctivitis of the right eye. Corneal ulceration and associated anterior chamber activity was noted later in the course of the disease. Neisseria gonorrhoeae was positive on polymerase chain reaction (PCR) testing earlier than traditional microscopy and culture. He was successfully treated with ceftriaxone 500 mg intravenously and azithromycin 1 g orally as single doses in addition to ofloxacin ophthalmic solution 0.3% hourly to the right eye. This case highlights the need to consider the possibility of gonococcus in cases of suspected bacterial conjunctivitis, careful monitoring for corneal involvement and the importance of early detection with PCR.

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