scholarly journals Oxidative DNA Damage in the Prostate May Predispose Men to a Higher Risk of Prostate Cancer

2009 ◽  
Vol 2 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Jennifer D. Wu ◽  
Daniel W. Lin ◽  
Stephanie T. Page ◽  
Ashley D. Lundgren ◽  
Lawrence D. True ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Oxidative Dna Damage

scholarly journals Oxidative DNA Damage in Prostate Cancer Patients Consuming Tomato Sauce-Based Entrees as a Whole-Food Intervention

2001 ◽  
Vol 93 (24) ◽  
pp. 1872-1879 ◽  
Author(s):  
L. Chen ◽  
M. Stacewicz-Sapuntzakis ◽  
C. Duncan ◽  
R. Sharifi ◽  
L. Ghosh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Cancer Patients ◽  
Oxidative Dna Damage ◽  
Tomato Sauce

OXIDATIVE DNA DAMAGE IN PATIENTS WITH PROSTATE CANCER AND ITS RESPONSE TO TREATMENT

2004 ◽  
Vol 171 (4) ◽  
pp. 1533-1536 ◽  
Author(s):  
HIDEAKI MIYAKE ◽  
ISAO HARA ◽  
SADAO KAMIDONO ◽  
HIROSHI ETO
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Response To Treatment

Oxidative DNA Damage-Mediated Genomic Heterogeneity Is Regulated by NKX3.1 in Prostate Cancer

2019 ◽  
Vol 37 (2) ◽  
pp. 113-126 ◽  
Author(s):  
Bilge Debelec-Butuner ◽  
Aykut Bostancı ◽  
Filiz Ozcan ◽  
Oznur Singin ◽  
Selda Karamil ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Oxidative Dna Damage

scholarly journals Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells

2012 ◽  
Vol 46 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Viviana de Rosa ◽  
Pinar Erkekoğlu ◽  
Anne Forestier ◽  
Alain Favier ◽  
Filiz Hincal ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Oxidative Dna Damage ◽  
Low Doses ◽  
Prostate Cancer Cells

scholarly journals The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor

Tumor Biology ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 159-176
Author(s):  
Richard J. Epstein
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Inflammatory Responses ◽  
Inducible Promoter ◽  
Loss Of Function ◽  
Coding Region ◽  
Antiinflammatory Drugs ◽  
Reading Frame ◽  
Secret Identities

The human TMPRSS2 gene is pathogenetically implicated in both coronaviral lung infection and prostate cancer, suggesting its potential as a drug target in both contexts. SARS-COV-2 spike polypeptides are primed by the host transmembrane TMPRSS2 protease, triggering virus fusion with epithelial cell membranes followed by an endocytotic internalisation process that bypasses normal endosomal activation of cathepsin-mediated innate immunity; viral co-opting of TMPRSS2 thus favors microbial survivability by attenuating host inflammatory responses. In contrast, most early hormone-dependent prostate cancers express TMPRSS2:ERG fusion genes arising from deletions that eliminate the TMPRSS2 coding region while juxtaposing its androgen-inducible promoter and the open reading frame of ERG, upregulating pro-inflammatory ERG while functionally disabling TMPRSS2. Moreover, inflammatory oxidative DNA damage selects for TMPRSS2:ERG-fused cancers, whereas patients treated with antiinflammatory drugs develop fewer of these fusion-dependent tumors. These findings imply that TMPRSS2 protects the prostate by enabling endosomal bypass of pathogens which could otherwise trigger inflammation-induced DNA damage that predisposes to TMPRSS2:ERG fusions. Hence, the high oncogenic selectability of TMPRSS2:ERG fusions may reflect a unique pro-inflammatory synergy between androgenic ERG gain-of-function and fusogenic TMPRSS2 loss-of-function, cautioning against the use of TMPRSS2-inhibitory drugs to prevent or treat early prostate cancer.

Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults

2020 ◽  
Author(s):  
Bin Wang ◽  
Weihong Qiu ◽  
Shijie Yang ◽  
Limin Cao ◽  
Chunmei Zhu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Oxidative Dna Damage ◽  
Adult Population ◽  
Prostaglandin F2α ◽  
Mediation Analyses ◽  
Mediating Role ◽  
Fasting Plasma

<a><b>OBJECTIVE: </b></a>Acrylamide exposure from daily-consumed food has raised global concern.<b> </b>We aimed to assess the exposure-response relationships of internal acrylamide exposure with oxidative DNA damage, lipid peroxidation and fasting plasma glucose (FPG) alteration, and investigate the mediating role of oxidative DNA damage and lipid peroxidation in the association of internal acrylamide exposure with FPG. <p><b>RESEARCH DESIGN AND METHODS:</b> FPG and urinary biomarkers of oxidative DNA damage (8-hydroxy-deoxy-guanosine, 8-OHdG), lipid peroxidation (8-iso-prostaglandin-F2α, 8-iso-PGF2α) and acrylamide exposure (N-acetyl-S-(2-carbamoylethyl)-L-cysteine, AAMA; N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine, GAMA) were measured for 3,270 general adults from the Wuhan-Zhuhai cohort. The associations of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG were assessed by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2α were evaluated by mediation analysis.</p> <p><b>RESULTS:</b> We found significant linear positive dose-response relationships of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG (except GAMA with FPG), and 8-iso-PGF2α with FPG. Each 1-unit increase in log-transformed level of AAMA, ΣUAAM (AAMA+GAMA) or 8-iso-PGF2α was associated with a 0.17-, 0.15- or 0.23-mmol/L increase in FPG, respectively (<i>P </i>or/and<i> P trend</i><0.05). Each 1% increase in AAMA, GAMA or ΣUAAM was associated with a 0.19%, 0.27% or 0.22% increase in 8-OHdG, respectively, and a 0.40%, 0.48% or 0.44% increase in 8-iso-PGF2α, respectively (<i>P </i>and<i> P trend</i><0.05). Increased 8-iso-PGF2α rather than 8-OHdG significantly mediated 64.29% and 76.92% of the AAMA and ΣUAAM associated-FPG increases, respectively.</p> <p><b>CONCLUSIONS:</b> Exposure of general adult population to acrylamide was associated with FPG elevation, oxidative DNA damage and lipid peroxidation, which in turn partly mediated acrylamide-associated FPG elevation.<b></b></p>

Serum of 8-OHdG as a potential biomarker of oxidative DNA damage in workers exposed to harmful working environments

2020 ◽  
pp. 783-783
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Blood Serum ◽  
Oxidative Dna Damage ◽  
Working Environment ◽  
Working Environments ◽  
Potential Biomarker ◽  
High Level ◽  
Damage Marker

In the blood serum of 70% individuals exposed to harmful factors of the working environment, a high level of oxidative stress and the DNA damage marker 8-Hydroxy-2’-Deoxyguanosine (8-OHdG) were detected.

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