PART III. AutoimmunityAn Altered Peptide Ligand of Type II Collagen Suppresses Autoimmune Arthritis

2007 ◽  
Vol 27 (4) ◽  
pp. 345-356 ◽  
Author(s):  
Linda K. Myers ◽  
Bo Tang ◽  
Edward F. Rosioniec ◽  
John M. Stuart ◽  
Andrew H. Kang
Keyword(s):  
Type Ii Collagen ◽  
Peptide Ligand ◽  
Autoimmune Arthritis ◽  
Altered Peptide Ligand ◽  
Type Ii

scholarly journals Molecular Basis for T Cell Response Induced by Altered Peptide Ligand of Type II Collagen

2012 ◽  
Vol 287 (23) ◽  
pp. 19765-19774 ◽  
Author(s):  
Jeoung-Eun Park ◽  
David Cullins ◽  
Lillian Zalduondo ◽  
Stacey L. Barnett ◽  
Ae-Kyung Yi ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Molecular Basis ◽  
Type Ii Collagen ◽  
T Cell Response ◽  
Peptide Ligand ◽  
Altered Peptide Ligand ◽  
Type Ii

Structures on the I-A molecule predisposing for susceptibility to type II collagen-induced autoimmune arthritis

1990 ◽  
Vol 20 (9) ◽  
pp. 2127-2131 ◽  
Author(s):  
Kenth Gustafsson ◽  
Mikael Karlsson ◽  
Leif Andersson ◽  
Rikard Holmdahl
Keyword(s):  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii

Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis

2004 ◽  
Vol 50 (9) ◽  
pp. 3004-3011 ◽  
Author(s):  
L. K. Myers ◽  
B. Tang ◽  
D. D. Brand ◽  
E. F. Rosloniec ◽  
J. M. Stuart ◽  
...  
Keyword(s):  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii ◽  
Recombinant Type

Immunopathogenic Mechanisms in Type II Collagen Autoimmune Arthritis

1986 ◽  
Vol 5 (3-5) ◽  
pp. 297-304
Author(s):  
William C. Watson ◽  
Alexander S. Townes ◽  
Andrew H. Kang
Keyword(s):  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii

scholarly journals 20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis

2021 ◽  
Vol 12 ◽  
Author(s):  
Arnold E. Postlethwaite ◽  
Robert C. Tuckey ◽  
Tae-Kang Kim ◽  
Wei Li ◽  
Syamal K. Bhattacharya ◽  
...  
Keyword(s):  
T Cells ◽  
Inflammatory Cytokines ◽  
Lymphocyte Subsets ◽  
Clinical Signs ◽  
Joint Damage ◽  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii ◽  
Cytochrome P450scc ◽  
Pro Inflammatory Cytokines

The ability to use large doses of vitamin D3 (D3) to chronically treat autoimmune diseases such as rheumatoid arthritis (RA) is prohibitive due to its calcemic effect which can damage vital organs. Cytochrome P450scc (CYP11A1) is able to convert D3 into the noncalcemic analog 20S-hydroxyvitamin D3 [20S(OH)D3]. We demonstrate that 20S(OH)D3 markedly suppresses clinical signs of arthritis and joint damage in a mouse model of RA. Furthermore, treatment with 20S(OH)D3 reduces lymphocyte subsets such as CD4+ T cells and CD19+ B cells leading to a significant reduction in inflammatory cytokines. The ratio of T reg cells (CD4+CD25+Foxp3+ T cells) to CD3+CD4+ T cells is increased while there is a decrease in critical complement-fixing anti-CII antibodies. Since pro-inflammatory cytokines and antibodies against type II collagen ordinarily lead to destruction of cartilage and bone, their decline explains why arthritis is attenuated by 20(OH) D3. These results provide a basis for further consideration of 20S(OH)D3 as a potential treatment for RA and other autoimmune disorders.

Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen

1993 ◽  
Vol 23 (3) ◽  
pp. 591-599 ◽  
Author(s):  
Grace Ku ◽  
Mitchell Kronenberg ◽  
Derek J. Peacock ◽  
Paul Tempst ◽  
Mona Lisa Banquerigo ◽  
...  
Keyword(s):  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii ◽  
Peptide Fragment ◽  
Experimental Autoimmune

scholarly journals Breaking T cell tolerance against self-type II collagen in HLA-DR4 transgenic mice and development of autoimmune arthritis

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Tsvetelina Batsalova ◽  
Balik Dzhambazov ◽  
Patrick Merky ◽  
Alexandra Bäcklund ◽  
Johan Bäcklund
Keyword(s):  
T Cell ◽  
Transgenic Mice ◽  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii ◽  
T Cell Tolerance ◽  
Cell Tolerance

scholarly journals INDUCTION OF CHRONIC AUTOIMMUNE ARTHRITIS IN DBA/1 MICE BY ORAL ADMINISTRATION OF TYPE II COLLAGEN AND ESCHERICHIA COLl LIPOPOLYSACCHARIDE

Rheumatology ◽  
1996 ◽  
Vol 35 (9) ◽  
pp. 828-838 ◽  
Author(s):  
K. TERATO ◽  
X. J. YE ◽  
H. MIYAHARA ◽  
M. A. CREMER ◽  
M. M. GRIFFITHS
Keyword(s):  
Oral Administration ◽  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii

MODULATION OF AUTOIMMUNE ARTHRITIS BY A GLYCOSYLATED ANALOG PEPTIDE OF TYPE II COLLAGEN.

2007 ◽  
Vol 55 (1) ◽  
pp. S278
Author(s):  
L. K. Myers ◽  
B. Tang ◽  
J. M. Stuart ◽  
A. H. Kang
Keyword(s):  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii ◽  
Analog Peptide

scholarly journals Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis

2012 ◽  
Vol 14 (3) ◽  
pp. R107 ◽  
Author(s):  
Masaru Kimata ◽  
David L Cullins ◽  
Monica L Brown ◽  
David D Brand ◽  
Edward F Rosloniec ◽  
...  
Keyword(s):  
T Cells ◽  
Mouse Model ◽  
Type Ii Collagen ◽  
Autoimmune Arthritis ◽  
Type Ii ◽  
Humanized Mouse ◽  
Humanized Mouse Model
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