Anti-Inflammatory and Anti-Cancer Activity of Boswellic Acids from Frankincense (Boswellia serrata Roxb. et Colebr, B. carterii Birdw.)

2011 ◽  
Vol 2 (4) ◽  
pp. 303-313 ◽  
Author(s):  
Thomas Efferth ◽  
Henry Johannes Greten
Keyword(s):  
Boswellia Serrata ◽  
Boswellic Acids ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Cancer Activity

C5-curcuminoid-dithiocarbamate based molecular hybrids: synthesis and anti-inflammatory and anti-cancer activity evaluation

RSC Advances ◽  
2014 ◽  
Vol 4 (54) ◽  
pp. 28756-28764 ◽  
Author(s):  
Amit Anthwal ◽  
Kundan Singh ◽  
M. S. M. Rawat ◽  
Amit K. Tyagi ◽  
Bharat B. Aggarwal ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Activity Evaluation ◽  
Anti Cancer ◽  
Molecular Hybrids ◽  
Anti Inflammatory ◽  
New Compounds ◽  
Cancer Activity ◽  
Proliferation Potential

The C5-curcumin-dithiocarbamate analogues were synthesized in search of new molecules with anti-proliferation potential against cancer cells. These new compounds demonstrated higher anti-proliferation and anti-inflammatory activity against cancer cell lines in comparison to curcumin.

scholarly journals Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4957
Author(s):  
Wanda Baer-Dubowska ◽  
Maria Narożna ◽  
Violetta Krajka-Kuźniak
Keyword(s):  
Signaling Pathways ◽  
Oleanolic Acid ◽  
Short Review ◽  
Therapeutic Effects ◽  
Pentacyclic Triterpenoid ◽  
Anti Cancer ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Derivatives ◽  
Cancer Activity

Naturally occurring pentacyclic triterpenoid oleanolic acid (OA) serves as a good scaffold for additional modifications to achieve synthetic derivatives. Therefore, a large number of triterpenoids have been synthetically modified in order to increase their bioactivity and their protective or therapeutic effects. Moreover, attempts were performed to conjugate synthetic triterpenoids with non-steroidal anti-inflammatory drugs (NSAIDs) or other functional groups. Among hundreds of synthesized triterpenoids, still the most promising is 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), which reached clinical trials level of investigations. The new group of synthetic triterpenoids are OA oximes. The most active among them is 3-hydroxyiminoolean-12-en-28-oic acid morpholide, which additionally improves the anti-cancer activity of standard NSAIDs. While targeting the Nrf2 and NF-κB signaling pathways is the main mechanism of synthetic OA derivatives′ anti-inflammatory and anti-cancer activity, most of these compounds exhibit multifunctional activity, and affect cross-talk within the cellular signaling network. This short review updates the earlier data and describes the new OA derivatives and their conjugates in the context of modification of signaling pathways involved in inflammation and cell survival and subsequently in cancer development.

Isolation and Identification of Boswellic Acids by Modern Analytical Techniques

2021 ◽  
pp. 98-112
Author(s):  
Arshiya Zulfeen Mohd Fahim ◽  
Mohammed Shakir Ghouse ◽  
Syed Qumarul Islam ◽  
Mohammed Abdul Mughni Danish ◽  
Shaikh Mehmood ◽  
...  
Keyword(s):  
Experimental Work ◽  
Mineral Acid ◽  
Acid Fraction ◽  
Boswellic Acid ◽  
Isolation And Identification ◽  
Boswellia Serrata ◽  
Boswellic Acids ◽  
Complete Extraction ◽  
Anti Inflammatory ◽  
Work Done

Quality by Design (QbD) is a modern, scientific approach that formalizes product design, automates manual test¬ing, and streamlines troubleshooting. It uses a system¬atic approach to ensure quality by developing a thorough understanding of the compatibility of a finished product to all of the components and processes involved in manufac¬turing that product. Olibanum also known as “Dhup”, Indian Frankincense is an oleo gum resin of Boswellia species. In India it is obtained from Boswellia serrata. Boswellia serrata (Burseraceae) The major use of Boswellia serrata in contemporary medicine is as an anti-arthritic and anti-inflammatory pharmacological agent. The anti-inflammatory properties of the gum resin are attributed to the presence of “boswellic acids” The four major pentacyclic triterpenic acids present in the acidic extract of Boswellia serrata gum resin. β-Boswellic Acid, Acetyl-β-Boswellic Acid, 11-keto-β-Boswellic Acid, Acetyl-11-keto-β-Boswellic Acid. Oleo gum resin was subjected for solubility studies in different solvents. In this 10 commonly available solvents were used for extraction including water. All of them showed same TLC pattern except water. In case of maceration no heat is employed, but the material has to be extracted multiple times with fresh solvent each time. In this method solvent requirement increases. Each time the extract was checked for presence of boswellic acids by TLC to ensure complete extraction. It took 4-5 times repeated extraction for complete extraction of Boswellic acids by maceration. Literature survey reveals that anti-inflammatory activities associated with this resin are completely restricted to presence of Boswellic acids. So focus in experimental work done is placed on isolation of acid fraction of oleo gum resin. As mentioned in the procedures above acid fraction was obtained as white precipitate. This white precipitate was separated, dried and weighed. Amount of acid fraction obtained was determined on weight basis. In the experimental work done isolation of acid fraction was carried out by procedures mentioned in section above. This is common procedure which uses treatment of resin with alkali to convert acid into its salt and then precipitating salt of acid by using mineral acid. Studies were carried out to check variations in amount of acid portion obtained when parameters were altered. Use of 2% KOH followed by dilute hydrochloric acid as mineral acid will be most suitable.

scholarly journals Discovery of Compound A - a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity

Oncotarget ◽  
2015 ◽  
Vol 6 (31) ◽  
pp. 30730-30744 ◽  
Author(s):  
Ekaterina Lesovaya ◽  
Alexander Yemelyanov ◽  
Amanda C. Swart ◽  
Pieter Swart ◽  
Guy Haegeman ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Compound A ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Cancer Activity

scholarly journals Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Hyun Ji Eo ◽  
Jae Ho Park ◽  
Gwang Hun Park ◽  
Man Hyo Lee ◽  
Jeong Rak Lee ◽  
...  
Keyword(s):  
Morus Alba ◽  
Root Bark ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Cancer Activity
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