THE CONCENTRATIONS OF ANDROGENS, OESTROGENS, PROGESTERONE AND LUTEINIZING HORMONE IN THE SERUM OF FOETAL CALVES THROUGHOUT THE COURSE OF GESTATION

1974 ◽  
Vol 60 (1) ◽  
pp. 107-115 ◽  
Author(s):  
J. R. G. CHALLIS ◽  
C. K. KIM ◽  
F. NAFTOLIN ◽  
H. L. JUDD ◽  
S. S. C. YEN ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Maternal Plasma ◽  
Male And Female ◽  
Hormone Levels

SUMMARY The concentrations of luteinizing hormone (LH), progesterone, testosterone, androstenedione, oestrone and oestradiol in mixed umbilical cord blood taken from foetal calves during months 3 to 9 of gestation have been measured by radioimmunoassay. The levels of progesterone were low (compared with those in maternal plasma) and constant during pregnancy. There were large variations in the concentrations of androstenedione, oestrone, oestradiol and LH, with lower values found during months 7 to 8 of gestation. Significant differences (P < 0·05–< 0·001) in hormone levels between male and female foetuses were found for testosterone, LH, and the oestrogens during months 3 to 7, 3 and 4, and 7 and 8, respectively. No significant differences (P > 0·05) between sexes were found at any time between the concentrations of progesterone and androstenedione.

N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation

2004 ◽  
Vol 106 (5) ◽  
pp. 535-540 ◽  
Author(s):  
Timothy C. R. PRICKETT ◽  
Risto J. KAAJA ◽  
M. Gary NICHOLLS ◽  
Eric A. ESPINER ◽  
A. Mark RICHARDS ◽  
...  
Keyword(s):  
Cord Blood ◽  
Natriuretic Peptide ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Plasma Concentrations ◽  
Maternal Plasma ◽  
Fetal Tissues ◽  
Cord Plasma ◽  
Significant Difference ◽  
Gestational Group

We have identified recently a new peptide, NT-proCNP(1–50) (N-terminal pro-C-type natriuretic peptide), in the circulation of humans and sheep. A previous report of an elevated fetal–maternal gradient in immunoreactive CNP raised the possibility that processing and metabolism of proCNP may differ in maternal and fetal tissues. We therefore collected matching peripheral maternal and umbilical cord plasma samples at delivery from women with normotensive and pre-eclamptic pregnancies to investigate the presence and concentrations of CNP and NT-proCNP using HPLC and RIA. Plasma concentrations of NT-proCNP in normotensive umbilical cord plasma were 10-fold higher than maternal venous levels (246±17 compared with 24.3±1.8 pmol/l; P<0.001) and much higher than corresponding levels of CNP (3.6±0.4 compared with 1.8±0.3 pmol/l in the fetal and maternal plasma respectively; P<0.001). Although there was no significant difference between normotensive and pre-eclamptic plasma CNP concentrations in either maternal or umbilical cord blood, NT-proCNP showed a significant statistical interaction (F=5.8, P=0.025) between the source (maternal or fetal) and gestational group (normotensive or pre-eclamptic). Maternal NT-proCNP levels were raised in the pre-eclampsia group, whereas the converse was observed in umbilical cord blood. In conclusion, the greatly elevated ratio of NT-proCNP/CNP in fetal compared with maternal plasma suggests that synthesis, as well as clearance, of CNP (but not NT-proCNP clearance) are markedly increased in fetal tissues.

694: Maternal plasma and umbilical cord blood pharmacokinetics of cefazolin in obese gravidae at time of cesarean delivery

2015 ◽  
Vol 212 (1) ◽  
pp. S339-S340
Author(s):  
Omar Young ◽  
Imam Shaik ◽  
Roxanna Twedt ◽  
Anna Binstock ◽  
Andrew Althouse ◽  
...  
Keyword(s):  
Cord Blood ◽  
Cesarean Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Maternal Plasma

scholarly journals ASSESSMENT OF CORRELATION BETWEEN MIRNAS-21-3P AND -210-3P EXPRESSION IN MATERNAL AND UMBILICAL CORD PLASMA AND FETAL WEIGHT AT BIRTH

2021 ◽  
Vol 74 (2) ◽  
pp. 236-240
Author(s):  
Oksana D. Shchurevska ◽  
Svitlana I. Zhuk
Keyword(s):  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Maternal Blood ◽  
Maternal Plasma ◽  
High Positive Correlation ◽  
Positive Correlation ◽  
Fetal Plasma

The aim: To determine the degree of correlation of mass of the fetus and the level of mir-21, mir210 in maternal blood and umbilical cord blood of the fetus in uncomplicated gestation. Materials and methods: 60 pregnant women with a single baby pregnancy in the third trimester (37-40 weeks) were examined. They all were given a general clinical, obstetric and the level of miRNA21-3р and miRNA210-3р were determined in the whole blood of pregnant women (before labor) and in fetal blood obtained from the umbilical artery at birth. The level of miRNAs was determined by the TaqMan method. Results: After examining maternal and fetal plasma samples, we were able to determine 49 samples of hsa-miR210-3p and hsa-miR21-3p from maternal plasma, 44 samples of hsa-miR210-3p and 37 samples of hsa-miR21-3p from the cord blood, which is a satisfactory result of more than 50%. Subsequently, between the results obtained and the birth weight of the fetus Pearson’s correlation coefficient was studied. According to the results obtained, we found no correlation between fetal mass and hsa-miR210-3p level in maternal plasma (r-0,068674), low positive correlation of fetal mass with hsa-miR21-3p level in maternal plasma (r-0,212181 ), an average positive correlation with the level of hsa-miR21-3p in umbilical cord blood (r- 0.363374) and a high positive correlation with hsa-miR210-3p in umbilical cord blood (r-0.528616). Conclusions: Determination of the level of hypoxic miRNAs, in particular hsa-miR210-3p in the umbilical cord blood of the newborn may be a marker of the functional status of the placenta, which programs the normal development of the fetus.

Maternal Acrylamide Intake during Pregnancy and Sex Hormone Levels in Maternal and Umbilical Cord Blood and Birth Size of Offspring

2018 ◽  
Vol 71 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Chisato Nagata ◽  
Kie Konishi ◽  
Keiko Wada ◽  
Takashi Tamura ◽  
Yuko Goto ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Sex Hormone ◽  
Birth Size ◽  
Hormone Levels
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