Today, people are going to senior managers in almost all industries pitching about their “I have a new product” thing. Disruptive technology transforms a differentiated product that was so expensive and sometimes complicated or sophisticated into a simplified implementation with the applicability of APIs. APIs provide a platform where startup companies can be nitrated to a giant and established companies. Secondly, it changes the business ecosystem to suit all kinds of players small or big. In previous years, only major companies with a lot of resources had access to such technologies. This selfish access to new technologies would make such giants flourish like Amazon, eBay, Google. Blockchain is a form of distributed ledger technology gaining significant research devotion in numerous areas cutting across e-commerce, cryptocurrency, cryptography, logistics, security, finance, and now it is gaining grounds in e-commerce, big data, and internet of things. This chapter introduces the concept of blockchain, applications, and benefits it possesses in various fields related to e-commerce.