scholarly journals Time and Frequency Dependent Protective Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) On Neuronal Cell Survival after a Profound Neurometabolic Insult (Oxygen and Glucose Deprivation)

2021 ◽  
Vol 18 (2) ◽  
Author(s):  
Şeyda Çankaya ◽  
Muzaffer Beyza Ozansoy
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Protective Effect ◽  
Cell Survival ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Neuronal Cell ◽  
Glucose Deprivation ◽  
Frequency Dependent ◽  
Oxygen And Glucose Deprivation

Frequency-dependent effects of repetitive transcranial magnetic stimulation on the human brain

Neuroreport ◽  
2012 ◽  
Vol 23 (18) ◽  
pp. 1065-1070 ◽  
Author(s):  
Tetsuya Torii ◽  
Aya Sato ◽  
Yukiko Nakahara ◽  
Masakuni Iwahashi ◽  
Yuji Itoh ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Human Brain ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Frequency Dependent

scholarly journals Repetitive transcranial magnetic stimulation improves neurological function after cerebral ischemia in rats by increasing CREB-regulated TrkB via activation of cAMP/PKA and Ca2+/CaMKIV signaling pathways

2019 ◽  
Author(s):  
Lisha Chang ◽  
Zhaowang An ◽  
Jiang Zhang ◽  
Fuling Zhou ◽  
Dali Wang ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Cerebral Ischemia ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Glucose Deprivation ◽  
Artery Occlusion ◽  
Neurological Function ◽  
Nerve Recovery ◽  
Underlying Mechanisms

Abstract Background: Cerebral ischemia is the most prevalent form of clinical stroke. Repetitive transcranial magnetic stimulation (rTMS) can modulate excitability of the cerebral cortex, and this effect is maintained after the stimulation is terminated. However, the underlying mechanisms of rTMS in cerebral ischemia remain unclear. Methods: Herein, we identified the effect of rTMS on cerebral ischemia and further explored the underlying mechanisms. An in vitro model was established using primary cultured neurons under conditions of oxygen-glucose deprivation (OGD), followed by 1 Hz or 10 Hz rTMS treatment. The levels of CREB, PKA and CaMKIV were depleted in neurons to explore the underlying regulatory mechanisms of TrkB by rTMS via CREB. A rat model of cerebral ischemia was established by middle cerebral artery occlusion (MCAO) and the rats were treated with 1 Hz or 10 Hz rTMS to investigate the effect of rTMS on neurobehavior, CREB expression, and cAMP/PKA and Ca 2+ /CaMKIV pathways. Results: rTMS was observed to promote nerve recovery ability in rats with cerebral ischemia, which was accompanied by high expression of TrkB. In OGD-treated neurons, rTMS activated CREB by upregulating cAMP/PKA and Ca 2+ /CaMKIV pathways. Moreover, rTMS induced the activation of CREB to upregulate TrkB. In MCAO rats, rTMS increased the CREB expression, enhanced cAMP, PKA and CaMKIV phosphorylation, and promoted the binding of CREB to TrkB. Conclusions: Taken together, rTMS upregulated CREB and TrkB to improve neurological function in rats with cerebral ischemia by activating cAMP/PKA and Ca 2+ /CaMKIV pathways, which could be of great significance for cerebral ischemia therapy.

Frequency-dependent effects of contralateral repetitive transcranial magnetic stimulation on penicillin-induced seizures

2014 ◽  
Vol 1581 ◽  
pp. 103-116 ◽  
Author(s):  
Ching-Yi Lin ◽  
Kevin Li ◽  
Linda Franic ◽  
Jorge Gonzalez-Martinez ◽  
Vernon W. Lin ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Frequency Dependent
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