About early diagnosis of vitamin deficiency

1937 ◽  
Vol 33 (2) ◽  
pp. 121-126
Author(s):  
E. M. Lepsky

In the expressed form of avitaminosis, we are now observed less and less. Nevertheless, the problem of vitamin deficiencies remains relevant for the practitioner. As the physiological role of vitamins and their importance in pathology becomes more and more clear, the presence of light, "erased" forms, which are more correctly called hypovitaminosis, becomes more and more obvious. Experience shows that the generally accepted ideas about the conditions for the occurrence of avitaminosis should be revised. Not only in the absence or in the absence of one or another vitamin in food, vitamin deficiency can develop. More and more observations are accumulating showing that a weak or even strongly pronounced vitamin deficiency can appear in a person who receives a completely complete diet. This phenomenon, paradoxical at first glance, can take place under the following circumstances: with digestive disorders associated with impaired absorption; with liver diseases (the latter is especially important for vitamin A deficiency, since the conversion of carotene into vitamin A suffers); when the need for vitamins is increased against the norm, for example, in rapidly growing children or in lactating women who excrete significant amounts of vitamin C with milk; with increased destruction of vitamin stores in the body, which is observed with all kinds of infections and other febrile and debilitating diseases. To what has been said, it must also be added that very often our food turns out to be poor in vitamins, due to irrational preparation, improper storage of food, peculiar deviations of appetite, etc. In the earliest stages, when even mild clinical symptoms do not yet exist, modern methods of studying vitamins can the presence of latent hypovitaminosis. This is especially evident in the example of the scourge.

2019 ◽  
Vol 5 (2) ◽  
pp. 106-109
Author(s):  
Prasetyaningsih Prasetyaningsih

Background: Vitamin A is one of the important nutrients that are fat-soluble and stored in the liver, cannot be made by the body, so it must be fulfilled from the outside (essential). 40 million children suffer from vitamin A deficiency and 13 million children show clinical symptoms of eye disorders. Pariaman Health Center is the region with the lowest coverage of vitamin A, which is 74% of 1546 toddlers. The purpose of this study was to determine the correlation between the level of knowledge and attitudes of mothers with giving vitamin A for toddler in Pariaman Health Center, pariaman city, 2017. Methods: This type of analytic descriptive research using the approach is cross sectional. The study was conducted in Pariaman Health Center in September 2017. The study population was mothers who had toddler who were in the work area of Pariaman Health Center totaling 1,546 people, 93 samples were obtained using accidental sampling method Data processing was Univariate and Bivariate using Chi Square analysis computerized. Results: Univariate results showed that 51.6% had low knowledge, 64.5% had a negative attitude, 64.5% gave vitamin A capsules for toddlers. There is a significant relationship between the knowledge of mothers with giving vitamin A for toddlers, p value 0.001 <0.05. There was a significant correlation between the attitudes of mothers with giving vitamin A, p value 0.001 <0.05. Conclusion: The low coverage of vitamin A in Pariaman Health Center was apparently influenced by a lack of knowledge and also a negative mother's attitude. It is expected that the health center will further improve health services to the community, should counseling about vitamin A be held every month so that mothers' understanding of vitamin A increases


2014 ◽  
Vol 84 (Supplement 1) ◽  
pp. 52-59 ◽  
Author(s):  
Sherry A. Tanumihardjo ◽  
Anura V. Kurpad ◽  
Janet R. Hunt

The current use of serum retinol concentrations as a measurement of subclinical vitamin A deficiency is unsatisfactory for many reasons. The best technique available for vitamin A status assessment in humans is the measurement of total body pool size. Pool size is measured by the administration of retinol labelled with stable isotopes of carbon or hydrogen that are safe for human subjects, with subsequent measurement of the dilution of the labelled retinol within the body pool. However, the isotope techniques are time-consuming, technically challenging, and relatively expensive. There is also a need to assess different types of tracers and doses, and to establish clear guidelines for the use and interpretation of this method in different populations. Field-friendly improvements are desirable to encourage the application of this technique in developing countries where the need is greatest for monitoring the risk of vitamin A deficiency, the effectiveness of public health interventions, and the potential of hypervitaminosis due to combined supplement and fortification programs. These techniques should be applied to validate other less technical methods of assessing vitamin A deficiency. Another area of public health relevance for this technique is to understand the bioconversion of β-carotene to vitamin A, and its relation to existing vitamin A status, for future dietary diversification programs.


2021 ◽  
pp. 037957212110602
Author(s):  
Mark Pretzel P. Zumaraga ◽  
Jose Maria Reynaldo Apollo Arquiza ◽  
Mae Anne Concepcion ◽  
Leah Perlas ◽  
Ma. Neda Alcudia-Catalma ◽  
...  

Background: The study aimed to identify two beta-carotene 15,15′-monooxygenase (BCMO1) mutations, namely R267S and A379V, and determine their association with vitamin A status among Filipinos 6 to 19 years old respondents of the 2013 Philippine National Nutrition Survey living in the National Capital Region. Materials and Methods: This study followed cross-sectional design. Whole blood specimen was collected in the morning and was used as source of genomic DNA and serum for retinol concentration determination. Fisher exact test was performed to determine whether genotype frequencies were associated to retinol concentrations/vitamin A deficiency status. A level of P < .05 was identified as significant. Results: A total of 693 Filipino children and adolescents were included. Of the 693, there were at least 7.6% who bears the combined mutations for R267S + A379V. Association analysis showed that an inverse relationship exists between the A379V TT variant and vitamin A status. Although the exact role of these identified polymorphisms on retinol/carotenoid metabolism need to be confirmed in dedicated functional studies. Conclusion: This study has identified for the first time the presence of 2 nonsynonymous genetic variants/mutations in the coding region of BCMO1 gene. Interestingly, one of these two variants, the A379V T, was found to be associated with vitamin A status. It is, therefore, warranted to investigate the role of BCMO1 variants for the success of supplementation programs and fortification efforts among vulnerable populations in this region. Genetic variability should be considered for future provitamin A supplementation recommendations among children and adolescents in the Philippines.


2021 ◽  
Vol 16 (4) ◽  
pp. 77-83
Author(s):  
Anna Yatsenko ◽  
Lidiya Trankovskaya ◽  
Olga Artyulova

Subject. The scientific works of recent years show an increase in the degree of negative impact of vitamin deficiency and vitamin-like substances on the state of health of the population. With the deficiency of most vitamins, synthetic processes and regeneration of oral tissues are reduced, so often the initial signs of hypovitaminosis are stomatitis, gingivitis, glossitis, and therefore, it is dentists who are the first to diagnose deviations in the body associated with vitamin deficiency. This justifies the relevance and practical value of studying and describing clinical cases of manifestations of deficient vitamin conditions in the oral cavity. The object – is to study the effect of B vitamins on the oral mucosa in order to increase the effectiveness of diagnosis of vitamin-deficient conditions of the human body. Methodology. These clinical examples illustrate the management experience of patients with manifestations of deficient vitamin conditions on the oral mucosa. Clinical and laboratory methods of diagnosing the analysed conditions of the organism were applied. Statistical processing of materials was carried out using the STATISTICA 10 software (StatSoft, Inc., USA). Results. The deficient condition of the organism in relation to vitamins B2, B6, B12 in patients 18-75 years old has been studied. Characteristic clinical changes on the oral mucosa of the examined patients were established. So, in most patients with vitamin B2 deficiency, the classic Sebrel triad was found: dermatitis, glossitis, cheilitis. In those examined with a lack of vitamin B6, language desquamations (smoothed, polished language) were determined in the 83.6%, often combined with glossodinia. Patients with vitamin B12 deficiency were characterized by a lesion in the form of Meller-Gunter glossitis in 74.9% of cases, moreover, 67.6% of patients showed paresthesia in the area of tongue and oral mucosa. Conclusions. The study found that the first clinical symptoms of deficient conditions of the presented vitamins of group B were found from the oral cavity. Thus, it is the dentist who is the first to diagnose the pathological states of lack of group B vitamins in the human body, which emphasizes the importance and relevance of continuing to study these states of the body.


2020 ◽  
Vol 14 ◽  
Author(s):  
Isis Zhang ◽  
Huijuan Hu

Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), an important pathway for calcium signaling throughout the body. While the activity of SOCs has been well studied in non-excitable cells, attention has turned to their role in neurons and glia in recent years. In particular, the role of SOCs in the nervous system has been extensively investigated, with links to their dysregulation found in a wide variety of neurological diseases from Alzheimer’s disease (AD) to pain. In this review, we provide an overview of their molecular components, expression, and physiological role in the nervous system and describe how the dysregulation of those roles could potentially lead to various neurological disorders. Although further studies are still needed to understand how SOCs are activated under physiological conditions and how they are linked to pathological states, growing evidence indicates that SOCs are important players in neurological disorders and could be potential new targets for therapies. While the role of SOCE in the nervous system continues to be multifaceted and controversial, the study of SOCs provides a potentially fruitful avenue into better understanding the nervous system and its pathologies.


2007 ◽  
Vol 282 (46) ◽  
pp. 33553-33561 ◽  
Author(s):  
Susanne Hessel ◽  
Anne Eichinger ◽  
Andrea Isken ◽  
Jaume Amengual ◽  
Silke Hunzelmann ◽  
...  

Carotenoids are currently investigated regarding their potential to lower the risk of chronic disease and to combat vitamin A deficiency in humans. These plant-derived compounds must be cleaved and metabolically converted by intrinsic carotenoid oxygenases to support the panoply of vitamin A-dependent physiological processes. Two different carotenoid-cleaving enzymes were identified in mammals, the classical carotenoid-15,15′-oxygenase (CMO1) and a putative carotenoid-9′,10′-oxygenase (CMO2). To analyze the role of CMO1 in mammalian physiology, here we disrupted the corresponding gene by targeted homologous recombination in mice. On a diet providing β-carotene as major vitamin A precursor, vitamin A levels fell dramatically in several tissues examined. Instead, this mouse mutant accumulated the provitamin in large quantities (e.g. as seen by an orange coloring of adipose tissues). Besides impairments in β-carotene metabolism, CMO1 deficiency more generally interfered with lipid homeostasis. Even on a vitamin A-sufficient chow, CMO1-/- mice developed a fatty liver and displayed altered serum lipid levels with elevated serum unesterified fatty acids. Additionally, this mouse mutant was more susceptible to high fat diet-induced impairments in fatty acid metabolism. Quantitative reverse transcription-PCR analysis revealed that the expression of peroxisome proliferator-activated receptor γ-regulated marker genes related to adipogenesis was elevated in visceral adipose tissues. Thus, our study identifies CMO1 as the key enzyme for vitamin A production and provides evidence for a role of carotenoids as more general regulators of lipid metabolism.


1987 ◽  
Vol 15 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Leena Tenkanen ◽  
Lyly Teppo

To study the importance of migration to urban area, marital status and smoking as risk factors in cancer, a cohort of 4475 Finnish men was followed up for the occurrence of cancer during the period 1964–1980. Of particular interest was the interaction of migration or marital status with smoking. For cancers at all sites, not married urbanized smoking men had the greatest risk, followed by not married native urban smokers. This pattern was mainly due to high risk of cancers of the lung and larynx among the urbanized men, with a risk peak among urbanized not married smokers. The pattern persisted even when the amount smoked was allowed for. The importance in lung cancer epidemiology of vitamin A deficiency, occupation and psychosocial stress was discussed, and some support was found for the role of psychosocial stress in both the migration and the marital status factors.


1995 ◽  
Vol 142 (8) ◽  
pp. 843-855 ◽  
Author(s):  
Martin W. Bloem ◽  
Abdul Hye ◽  
Marijke Wijnroks ◽  
Ann Ralte ◽  
Keith P. West ◽  
...  

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