Use of pentagastrin for correction of the functional state of liver after stomach resection

1999 ◽  
Vol 80 (5) ◽  
pp. 378-381
Author(s):  
L. A. Ivanov
Keyword(s):  
Functional State ◽  
Clinical Symptoms ◽  
Synthetic Analog ◽  
Excretory Function ◽  
Liver Functions ◽  
Operated Stomach ◽  
Stomach Resection

The disorder of the functional state of liver is found in 67,7% of patients after stomach resection. Significance of the disorder of the absorption excretory function of liver in developing postgastroresectional disturbances is shown. For correction of the disorders of liver functions the synthetic analog of the gastrin, gastrointestinal hormonepentagastrin is used which caused recovery of liver functions and improvement of the functional state of operated stomach along with positive dynamics of clinical symptoms.

scholarly journals Quantitative liver functions in Turner syndrome with and without hormone replacement therapy

2007 ◽  
Vol 156 (6) ◽  
pp. 679-686 ◽  
Author(s):  
Claus Højbjerg Gravholt ◽  
Henrik Enghusen Poulsen ◽  
Peter Ott ◽  
Jens Sandahl Christiansen ◽  
Hendrik Vilstrup
Keyword(s):  
Hormone Replacement Therapy ◽  
Indocyanine Green ◽  
Replacement Therapy ◽  
Turner Syndrome ◽  
Liver Enzymes ◽  
Hormone Replacement ◽  
Amino Nitrogen ◽  
Excretory Function ◽  
Liver Functions ◽  
Galactose Elimination Capacity

Background: Studies have documented elevated levels of liver enzymes in many females with Turner syndrome (TS). Histology has shown a range of changes. Treatment with female hormone replacement therapy (HRT) reduces liver enzymes. Aim: To study quantitative liver functions in TS in detail with and without HRT. Design: Randomized crossover study with active treatment (HRT in TS and P-pill in controls) or no treatment. Subjects: Women with TS (n = 8, age 29.7 ± 5.6 (mean ± s.d.) years), verified by karyotype, and age-matched controls (C; n = 8, age 27.3 ± 4.9 years). Methods: We determined liver enzymes in blood, used the galactose elimination capacity to assess hepatocyte cytosol activity, plasma clearance of indocyanine green to assess excretory function, antipyrine clearance to estimate microsomal activity, and the functional hepatic nitrogen clearance (FHNC) to assess mitochondrial-cytosolic metabolic capacity for conversion of amino-nitrogen. Results: Liver enzymes were elevated in untreated TS and reduced by HRT. The hepatic capacities for conversion of galactose, indocyanine green, and antipyrine were normal and did not change by HRT. The FHNC was marginally reduced (untreated TS vs C: 19.4 ± 5.4 vs 25.2 ± 7.3 L/h, P = 0.1). FHNC changed slightly with HRT in TS (19.4 ± 5.4 vs 24.4 ± 10.2 L/h, P = 0.2). Conclusions: The elevations of liver enzymes in untreated TS are readily suppressed by HRT. Quantitative liver functions in TS are comparable to controls and are not affected by HRT.

scholarly journals BARDET — BIEDL SYNDROME WITH CONGENITAL KIDNEY MALFORMATION IN A 14-YEAR-OLD GIRL

2019 ◽  
Vol 26 (3) ◽  
pp. 129-134
Author(s):  
Anna V. Burlutskaya ◽  
Natalia V. Savelyeva
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Development ◽  
Clinical Symptoms ◽  
Left Kidney ◽  
Hereditary Disease ◽  
Symptomatic Therapy ◽  
Excretory Function ◽  
Kidney Malformation ◽  
The Right

Aim. To show the variety and severity of the clinical symptoms of a rare hereditary disease — Вardet — Biedle syndrome — in a14-year-old girl. Materials and methods. We carried out a retrospective analysis of anamnestic data, the course of the disease, laboratory and instrumental data, as well as the therapy of a 14-year-old patient with Вardet-Вiedlе syndrome. Results. A 14-year-old patient with hereditary Вardet — Вiedlе syndrome (polydactyly, mental retardation, progressive obesity, pigment retinopathy) was found to have a congenital abnormality of kidney development — hypoplasia and dysplasia of the only right kidney complicated by chronic secondary pyelonephritis with the development of chronic kidney disease. Urine tests revealed leukocyturia, bacteriuria and proteinuria. The echo-signs of diffuse changes in the parenchyma of the right kidney were found during the ultrasound kidney examination. The left kidney was not determined. The conclusion of dynamic renal scintigraphy: the image of the left kidney is not reliably visualized (a sharp decrease in the function or absence of the kidney), the preserved filtration function and a moderate decrease in the excretory function of the right kidney. Intoxication syndrome, leukocyturia, bacteriuria and proteinuria were relieved against the background of antibacterial (Ceftriaxone) and symptomatic therapy. Conclusion. We have described a clinical case of the Вardet — Вiedlе syndrome with congenital kidney malformation (impaired function), but with the normal structure of the internal reproductive organs and sexual development. In the future, due to the development of chronic kidney disease, the patient should receive specialized nephrological care, as well as be observed by endocrinologist due to a high risk of developing type 2 diabetes mellitus.

scholarly journals Patterns of neurodegeneration in dementia reflect a global functional state space

2020 ◽  
Author(s):  
D. Jones ◽  
V. Lowe ◽  
J. Graff-Radford ◽  
H. Botha ◽  
D. Wiepert ◽  
...  
Keyword(s):  
Information Processing ◽  
State Space ◽  
Functional State ◽  
Large Scale ◽  
Clinical Symptoms ◽  
Brain Regions ◽  
Clinical Neurology ◽  
Brain Anatomy ◽  
Mental Functions ◽  
Mental Abilities

AbstractDisruption of mental functions in Alzheimer’s disease (AD) and related disorders is accompanied by selective degeneration of brain regions for unknown reasons. These regions comprise large-scale ensembles of cells organized into networks required for mental functioning. A mechanistic framework does not exist to explain the relationship between clinical symptoms of dementia, patterns of neurodegeneration, and the functional connectome. The association between dementia symptoms and degenerative brain anatomy encodes a mapping between mental functions and neuroanatomy. We isolated this mapping through unsupervised decoding of neurodegeneration in humans. This reflected a simple information processing-based functional description of macroscale brain anatomy, the global functional state space (GFSS). We then linked the GFSS to AD physiology, functional networks, and mental abilities. We extended the GFSS framework to normal aging and seven degenerative diseases of mental functions.One Sentence SummaryA global information processing framework for mental functions links neuroanatomy, cognitive neuroscience and clinical neurology.

scholarly journals Renal function in chronic lung diseases of non-tuberculous etiology

2021 ◽  
Vol 43 (3) ◽  
pp. 70-70
Author(s):  
A. M. Dadashyan ◽  
G. N. Sorokina
Keyword(s):  
Renal Function ◽  
Bronchial Asthma ◽  
Functional State ◽  
Lung Diseases ◽  
Excretory Function ◽  
Residual Nitrogen ◽  
Chronic Lung Diseases

We investigated the functional state of the kidneys in 20 patients with bronchiectasis, 13 with bronchial asthma and 7 with lung abscesses. Zimnitsky's test was normal in 12 patients, isogppostenuria and nocturia were found in 9, and nocturia in 19. Fonno's test was carried out in 31 patients. In 18 it turned out to be normal, in 13 patients a violation of the excretory function was revealed. Albuminuria was observed in 8, microhematuria - in 4, urobilinuria - in 17. The level of residual nitrogen was normal in 39 and increased in one patient.

scholarly journals Comparative assessment of premorbid period parameters and functional diagnostics indicators in military personnel with neurotic disorders

2021 ◽  
pp. 50-55
Author(s):  
A. A. Krasnov ◽  
E. Yu. Abritalin ◽  
V. V. Makeenko
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Functional State ◽  
Functional Assessment ◽  
Military Personnel ◽  
Clinical Symptoms ◽  
Maladaptive Behavior ◽  
Behavioral Characteristics ◽  
Global Functioning ◽  
Neurotic Disorders

Relevance. Combat missions imply high requirements for assessing mental health in military personnel. Among these requirements is the need to include functional assessment taking into account ontogenetic factors, compensatory and sanogenetic processes, personal and adaptive behavioral characteristics. At the same time, a number of authors note that the premorbid period of mental disorders can determine differences in the mental state during the period of manifestation of clinical symptoms.Intention. To investigate the relationship between the parameters of the functional state and the characteristics of the premorbid period of neurotic disorders in military personnel.Methodology. The study involved 78 male servicemen (average age 21.6 ± 2.6 years) with neurotic mental disorders. We studied information about the premorbid period, parameters of mental health functional assessment (bioelectric activity of the brain, cognitive functioning, behavioral characteristics, the global assessment of functioning).Results and Discussion. There were found statistically significant (p < 0.05) weak correlations between the number of adverse factors in the premorbid period and such indicators of the functional state as the severity of electroencephalographic disorders (r = 0.365); maladaptive behavior (r = 0.287), and statistically significant moderate correlation (r = –0.531) with the level of global functioning during the period of the greatest severity of neurotic symptoms.Conclusion. The data obtained in the study will make it possible to improve the forecast of the restoration of the working capacity of servicemen who have suffered from neurotic disorders, as well as the system of professional selection of applicants entering higher military educational institutions.

scholarly journals Estimation of the mucous membrane state of operated stomach in various methods of restoration of gastroenteric passage

2001 ◽  
Vol 82 (4) ◽  
pp. 256-260
Author(s):  
V. F. Naumov ◽  
N. P. Popov ◽  
S. R. Gabclraupova
Keyword(s):  
Mucous Membrane ◽  
Functional State ◽  
Surgical Intervention ◽  
Natural Food ◽  
Operated Stomach ◽  
Secretory Apparatus

The most rational option of surgical intervention making it possible to provide the optimal functional state of the secretory apparatus of the operated stomach is established. It is shown that the loss of the stomach part is accompanied by the atrophy of the mucous membrane of the preserved stomach part. In the cases when pylorus mechanism is preserved and the conditions close to the natural food chyme passage are reproduced, the mucous membrane atrophy with rough changes of its structures does not occur.

scholarly journals Breathing exercises with PEEP: efficiency and duration for correcting the cardiovascular system functional state in older patients with COPD

2021 ◽  
Vol 23 (6) ◽  
pp. 806-812
Author(s):  
E. O. Asanov ◽  
Yu. I. Holubova ◽  
I. A. Dyba ◽  
S. O. Asanova
Keyword(s):  
Cardiovascular System ◽  
Functional State ◽  
Older Patients ◽  
Clinical Symptoms ◽  
Control Group ◽  
System State ◽  
Initial State ◽  
Training Course ◽  
Breathing Exercises ◽  
Copd Patients

The aim of the work is to find out the effectiveness and duration of the breathing exercises with PEEP action on the cardiovascular system state in older patients with COPD. Materials and methods. A total of 35 patients with COPD aged 60–74 years were examined. All the patients were divided into two groups: the main group (18 people) who received breathing exercises with PEEP, and the control group (17 people) who received simulated exercises. The cardiovascular system state was assessed. The examinations were performed in the initial state (before training), immediately after, one month later, and three months after the training course. Results. The cardiovascular system state improved as a result of breathing exercises with PEEP in older patients with COPD. At the same time, the duration of the breathing exercises with PEEP action was short; the effect of their use was not preserved in a month. Relationships between shifts in SpO2 and cardiac output, as well as between shifts in SpO2 and peripheral vascular resistance immediately after the use of breathing exercises with PEEP in older patients with COPD have been established. A more significant and prolonged effect of breathing exercises with PEEP on the cardiovascular system functional state was observed in older COPD patients with more severe symptoms of the disease. Conclusions. The increase in cardiovascular performance was influenced by breathing exercises with PEEP in older COPD patients due to the improved lung oxygenation capacity. The effect of breathing exercises with PEEP remained within a month after the training course and was more stable and longer in patients with severe clinical symptoms. Older COPD patients are advised to repeat the courses of breathing exercises with PEEP every month.

scholarly journals Study of the functional state of liver in HIV-infected persons with the first diagnosed pulmonary tuberculosis

2018 ◽  
Vol 22 (1) ◽  
pp. 140-145
Author(s):  
O.P. Nezgoda ◽  
M.A. Thorovsky ◽  
V.V. Stryzhalkovska ◽  
S.O. Suchоk ◽  
A.A. Kushnir ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Functional State ◽  
Liver Damage ◽  
Total Bilirubin ◽  
Clinical Symptoms ◽  
Control Group ◽  
Intensive Phase ◽  
Ultrasound Evaluation ◽  
Ultrasound Study ◽  
Before And After

Simultaneous administration of anti-TB and antiretroviral therapy to patients with HIV contributes to the development of hepatotoxicity, which may be accompanied by a change in the laboratory and functional parameters of the liver. The purpose of the work is to investigate the functional state of the liver in HIV-infected persons with the first diagnosed pulmonary tuberculosis without combining with chronic hepatitis C. 49 patients were examined. The control group consisted of 25 patients with the first diagnosed pulmonary tuberculosis, the main – 24 patients with VDTB/HIV co-infection. The data of clinical, laboratory (ALT, AST, total bilirubin and its fractions, total protein of blood) and ultrasound examination before treatment and after the completion of the intensive phase of anti-TB therapy were evaluated. Clinically manifestations of intoxication were regressed more quickly in the control group. There was a statistically significant increase ALT in the main group compared to the control group after the intensive phase of treatment (p<0.05). Levels of total bilirubin and protein in both groups were not statistically different (p>0.05). The level of total bilirubin in both groups remained within the limits of physiological norm both before and after therapy. There was no significant increase those indicators, which could show the development of cholestasis syndrome. In the routine ultrasound study, conducted before and after the intensive phase, increased echogenicity of the liver, heterogeneity of the structure of the organ parenchyma, expansion of the intrahepatic ducts, hepatosplenomegaly. The presence of liver damage in patients with HIV/TB-co-infection was established at the pre-treatment stage, which wasn’t accompanied by severe clinical symptoms, consequently, in patients with HIV/TB co-infection it is expedient to conduct active monitoring of marker enzymes for cytolysis and ultrasound evaluation of liver status. The prevention of the development of medical liver damage in patients with HIV/TB co-infection contributes to the adequate implementation of an intensive phase of TB treatment.

Effects of Hypophysectomy on the Fine Structure of Rat Liver Cells

1967 ◽  
Vol 25 ◽  
pp. 156-157
Author(s):  
Robert R. Cardell
Keyword(s):  
Electron Microscopy ◽  
Fine Structure ◽  
Rat Liver ◽  
Liver Cell ◽  
Anterior Pituitary ◽  
Liver Cells ◽  
Biochemical Studies ◽  
Liver Functions ◽  
Rat Liver Cells ◽  
And Control

Hypophysectomy of the rat renders this animal deficient in the hormones of the anterior pituitary gland, thus causing many primary and secondary hormonal effects on basic liver functions. Biochemical studies of these alterations in the rat liver cell are quite extensive; however, relatively few morphological observations on such cells have been recorded. Because the available biochemical information was derived mostly from disrupted and fractionated liver cells, it seemed desirable to examine the problem with the techniques of electron microscopy in order to see what changes are apparent in the intact liver cell after hypophysectomy. Accordingly, liver cells from rats which had been hypophysectomized 5-120 days before sacrifice were studied. Sham-operated rats served as controls and both hypophysectomized and control rats were fasted 15 hours before sacrifice.

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