scholarly journals The dynamics of adrenal cortex and renal renin-angiotensin system hormone level of the patients with simple solitary cysts, complicated by symptomatic arterial hypertension

2012 ◽  
Vol 20 (2) ◽  
pp. 208
Author(s):  
A A Cherenkov ◽  
V G Aristarkhov
Keyword(s):  
Arterial Hypertension ◽  
Adrenal Cortex ◽  
Hormone Level ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Intrarenal renin-angiotensin system in hypertensive patients with localized kidney cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e17069-e17069
Author(s):  
Roman Osokin ◽  
Ekaterina Komarova ◽  
Igor Aboyan ◽  
Aleksey Yu. Maksimov ◽  
Roman Ischenko ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Kidney Cancer ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Hypertensive Patients ◽  
Renin Angiotensin ◽  
Peritumoral Tissue ◽  
The Relationship ◽  
Angiotensin Converting Enzymes

e17069 Background: In the last decade, the relationship between arterial hypertension and the risk of developing kidney cancer has been pointed out. Some studies have shown that the metabolic imbalance of the components of the renal renin-angiotensin system (RAS) is associated with the development and progression of kidney cancer. Aim: To study the state of RAS in tumor and peritumoral tissues in hypertensive patients with kidney cancer. Methods: In patients with localized kidney cancer T1N0M0 and grade I-II arterial hypertension without special treatment (n = 40; KC + AH) in the samples of tumor (TT), peritumoral (PTT) and histologically unchanged tissue (HUT), the levels of angiotensin 1 and 2, 1-7 (AT1 and AT2, AT (1-7)) of angiotensin-converting enzymes (ACE and ACE2) were determined by ELISA. The comparison group consisted of patients with RC without impaired blood pressure (n = 55, KC). Results: In patients with KC, the level of AT1 is 1.5 times higher (p < 0.05), and AT2 is 1.6 times higher (p < 0.05) in TT against the background of unchanged content in PTT compared with HUT. The level of ACE is higher than HUT by 2.7 times, ACE2 - by 1.6 times (in all cases p < 0.05), and in PTT it is identical in HUT. In patients with KC + AH, the level of AT1 and AT2 in the TT is 1.8 times higher (p < 0.05) and 2.1 times (p < 0.01), respectively, the content of AT(1-7) is 1.6 times (p < 0.01). In PTT, AT1 is 1.6 times higher (p < 0.01) and AT2 is 1.9 times higher (p < 0.05), significantly lower than only AT2 in the TT (1.2 times at p < 0, 05). The level of AT(1-7) in the PTT is identical to the values in the GNT. The content of ACE and ACE2 in TT is 3.6 and 2.9 times higher, respectively, and in PTT is identical to that in TT. Correlation analysis revealed a reliable direct relationship in the studied groups for all parameters, while in the PTT of hypertensive patients, the relationship between the average blood pressure and the RAS peptide content had a higher tightness. Conclusions: An increase in the levels of angiotensin 1 and 2, angiotensin-converting enzymes ACE and ACE2 in the tumor tissues and peritumoral tissue in patients with localized kidney cancer, regardless of the presence of arterial hypertension at initially higher values in hypertensive patients, was shown. The presence of arterial hypertension in patients with KC changes the metabolism of local RAS in peritumoral tissue and is associated with an increase in the correlation between changes in the components of RAS and arterial hypertension.

The serum level of the components of the renin-angiotensin system correlates with its tumor tissue expression in kidney cancer patients.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e17068-e17068
Author(s):  
Roman Osokin ◽  
Ekaterina Komarova ◽  
Igor Aboyan ◽  
Aleksey Yu. Maksimov ◽  
Natalya D. Ushakova ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Kidney Cancer ◽  
Peripheral Blood ◽  
Tumor Tissue ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Healthy Donors ◽  
Peritumoral Tissue ◽  
Angiotensin Converting Enzymes

e17068 Background: To date, it has not been decided whether the locally-generated components of the renin-angiotensin system (RAS) involved in the pathogenesis of kidney cancer and arterial hypertension, and are local and systemic RAS related? The aim was to assess the relationship of the level of RAS in the tumor tissue and peripheral blood in patients with localized kidney cancer with arterial hypertension. Methods: In patients with localized kidney cancer T1N0M0 (KС) and arterial hypertension of the I-II stage (AH), tissue and serum levels of angiotensin I, angiotensin II, angiotensin (1-7), as well as angiotensin converting enzymes (ACE and ACE2) were determined in the following groups: patients with KC without AH (n = 35, KC) and with concomitant AH (n = 30; KC+ AH). The normative values of peripheral blood indices were revealed in healthy donors (n = 30). Results: The level of all studied RAS peptides in the serum of patients with KC was increased in comparison with healthy donors regardless of concomitant hypertension, and the activity of both circulating angiotensin-converting enzymes, on the contrary, was increased only in patients with hypertension. The level of AT1 exceeds the control indicators by 1.7 times (KC) and 2.8 times (KC + AH). The formation of AT2 is higher in the KC + AH compared to KC (2.2 times versus 1.7 times, at p < 0.05). The content of AT (1-7) significantly exceeds the control (1.3 times on average, p < 0.05) and higher in the KC + AH. Increased enzyme activity was detected in KC + AG: increased by 1.5 times (p < 0.05) and 1.7 (p < 0.05) compared with the control for ACE and ACE2, respectively. The pair correlation coefficients between the serum RAS and the studied tissues in the KC were: for AT1 -0.78/0.65; АТ2-0.64/0.59 and АТ (1-7) - 0.56/0.51; ACE2 0.55/0.65 (for tumor/peritumoral tissue: in all cases at p < 0.05). In the KC+AH, these ratios were: for AT1 -0.85/0.81; АТ2-0.72/0.74 and АТ (1-7) - 0.65/0.59; ACE2 0.61/0.52 (for tumor / peritumoral tissue: in all cases at p < 0.05). Conclusions: The serum content of RAS peptides had positive statistical relationships with the corresponding parameters in tumor and peritumoral tissues of kidney cancer pts. However, in hypertensive patients with kidney cancer the correlations found had a tightness of higher strength. Positive correlations of the level of locally generated tumor parameters of RAS with their circulating analogues indicate the possibility of their use as diagnostic markers of the development of kidney cancer.

ACUTE ENZYME HISTOCHEMICAL CHANGES IN THE ZONA GLOMERULOSA OF THE RAT ADRENAL CORTEX

1971 ◽  
Vol 67 (1) ◽  
pp. 117-126
Author(s):  
J. D. Elema ◽  
M. J. Hardonk ◽  
A. Arends
Keyword(s):  
Peritoneal Dialysis ◽  
Adrenal Cortex ◽  
Renin Angiotensin System ◽  
Zona Glomerulosa ◽  
Experimental Conditions ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Histochemical Changes ◽  
Increased Activity ◽  
Total Nephrectomy

ABSTRACT In order to determine whether the increased enzyme histochemical activity of the zona glomerulosa of the rat adrenal cortex, as seen after peritoneal dialysis with 5 % glucose, is mediated by the renin-angiotensin system, and whether the increased activity as seen after total nephrectomy is a direct effect of changes in potassium balance, the effect of suppression of the renin-angiotensin system and of depletion of body potassium on these findings was investigated. Suppression of renin-angiotensin system activity and depletion of body potassium was accomplished by treatment of the rats with 2.5 mg deoxycorticosterone acetate given subcutaneously daily for 4 weeks. This treatment resulted in a delayed activation of the zona glomerulosa after peritoneal dialysis and a complete lack of reaction after total nephrectomy; the findings support the above mentioned assumptions about the manner in which the zona glomerulosa is activated in these experimental conditions.

Role of the Renin—Angiotensin System in Arterial Hypertension Secondary to Acute Unilateral Urinary Obstruction

Renal Failure ◽  
1994 ◽  
Vol 16 (6) ◽  
pp. 673-679 ◽  
Author(s):  
G. Hernández-Llamas ◽  
G. Palafox-Cervantes ◽  
Alma L. Borboa-Osuna ◽  
J. Urrecha-Manzano ◽  
C. Cruz ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Renin Angiotensin System ◽  
Urinary Obstruction ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Genetics and pathophysiology of low-renin arterial hypertension

2019 ◽  
Vol 22 (8) ◽  
pp. 1000-1008 ◽  
Author(s):  
A. L. Markel
Keyword(s):  
Arterial Hypertension ◽  
Molecular Genetic ◽  
Renin Angiotensin System ◽  
Hypertensive Disease ◽  
Genetic Determination ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Family Analysis ◽  
Low Renin Hypertension ◽  
Key Enzyme

The review is devoted to the consideration of genetic determination and pathophysiology of one of the forms of hypertensive disease known as low-renin hypertension. At frst glance, the development of low-renin hypertension is “unnatural”, as renin, as a key enzyme of the renin-angiotensin system, which plays an important role in the development of hypertensive disease, is suppressed in low-renin hypertension. At the same time, the most important drugs actual in the treatment of hypertensive disease belong to the renin-angiotensin system blockers. This contradiction was resolved by a study of genetic and pathophysiological mechanisms of hypertension in some groups of patients with characteristic symptoms bringing these people together. Genetic studies of some recent decades using both family analysis and modern molecular genetic technologies have revealed the main mechanisms underlying low-renin hypertension, which can be classifed as certain syndromes with well-defned genetic and clinical features. These syndromes include cases of sporadically occurring somatic mutations in the cells of the adrenal cortex, which begin to produce aldosterone in increased amounts. Also, several oligogenic forms of low-renin hypertension were studied, some of which are associated with the hyperproduction of aldosterone, but in the others the development of low-renin hypertension was associated with mutations of genes involved in regulation of the functioning of the kidney ion channels. The discovery of some types of arterial hypertension with known mechanisms of their development is of paramount importance for medicine, as it allows for targeted efective therapy and in some cases for achieving a complete cure. However, the main contingent of patients with low-renin hypertension belongs to cases with unexplained etiology, as their development is associated with polygenic systems and with a signifcant influence of numerous environmental factors. The study of genetic and physiological mechanisms of various forms of low-renin arterial hypertension provides a good example of how penetration into the intimate mechanisms of the blood pressure regulation in each personal case makes it possible to identify some specifc syndromes and establish its fnal causes. It seems that progress in understanding the causes and mechanisms of essential hypertension lies along this way.

scholarly journals Tissue synthesis of some components of the renin-angiotensin system in hypertensive patients with localized kidney cancer

2020 ◽  
Vol 16 (1) ◽  
pp. 27-34
Author(s):  
R. A. Osokin ◽  
I. A. Aboyan ◽  
E. F. Komarova ◽  
A. Yu. Maksimov ◽  
E. Yu. Komarova
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Kidney Cancer ◽  
Tumor Tissue ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Hypertensive Patients ◽  
Renin Angiotensin ◽  
Peritumoral Tissue ◽  
The Relationship

Background. In the last decade, the relationship between arterial hypertension and the risk of developing kidney cancer (KC) has been pointed out. Some studies have shown that the metabolic imbalance of the components of the renal renin-angiotensin system (RAS) is associated with the development and progression of KC.Objective: to study the state of RAS in tumor and peritumoral tissues in patients with KC on the background of arterial hypertension. Materials and methods. In patients with localized KC T1N0M0 and grade I–II arterial hypertension without special treatment (n = 40) in the samples of tumor, peritumoral and histologically unchanged tissue, the levels of angiotensins 1, 2, 1–7 (AT1, AT2, AT(1–7)) of angiotensin-converting enzymes (ACE, ACE2) were determined by ELISA. The comparison group consisted of patients with RC without impaired blood pressure (n = 55).Results. In patients with KC, the level of AT1 is 1.5 times higher (p <0.05), and AT2 is 1.6 times higher (p <0.05) in tumor tissue against the background of unchanged content in peritumoral tissue compared with histologically unchanged tissue. The level of ACE is higher than histologically unchanged tissue by 2.7 times, ACE2 – by 1.6 times (in all cases p <0.05), and in peritumoral tissue it is identical in histologically unchanged tissue.In patients with KC and arterial hypertension, the level of AT1 and AT2 in the tumor tissue is 1.8 times higher (p <0.05) and 2.1 times (p <0.01), respectively, the content of AT(1–7) is 1.6 times (p <0.01). In peritumoral tissue, AT1 is 1.6 times higher (p <0.01) and AT2 is 1.9 times higher (p <0.05). The level of AT(1–7) in the peritumoral tissue is identical to the values in the histologically unchanged tissue. The content of ACE and ACE2 in tumor tissue is 3.6 and 2.9 times higher, respectively, and in peritumoral tissue is identical to that in tumor tissue. Correlation analysis revealed a reliable direct relationship in the studied groups for all parameters, while in the peritumoral tissue of hypertensive patients, the relationship between the average blood pressure and the RAS peptide and enzymes content had a higher tightness.Conclusion. An increase in the levels of AT1 and AT2, ACE and ACE2 in the tumor tissues and peritumoral tissue in patients with localized KC, regardless of the presence of arterial hypertension at initially higher values in hypertensive patients, was shown. The presence of arterial hypertension in patients with KC changes the metabolism of local RAS in peritumoral tissue and is associated with an increase in the correlation between changes in the components of RAS and arterial hypertension.

ACUTE ENZYME HISTOCHEMICAL CHANGES IN THE ZONA GLOMERULOSA OF THE RAT ADRENAL CORTEX

1968 ◽  
Vol 59 (3) ◽  
pp. 519-528 ◽  
Author(s):  
J. D. Elema ◽  
M. J. Hardonk ◽  
Joh. Koudstaal ◽  
A. Arends
Keyword(s):  
Adrenal Cortex ◽  
Direct Effect ◽  
Renin Angiotensin System ◽  
Zona Glomerulosa ◽  
Bilateral Nephrectomy ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Histochemical Changes ◽  
Total Nephrectomy

ABSTRACT In order to evaluate a possible role of the renin-angiotensin system in enzyme histochemical changes of the rat adrenal cortex seen after acute hyponatraemia, the effect of a preceding total nephrectomy was investigated. By this procedure it was found that the alterations were largely inhibited. The results therefore favour a role of the renin-angiotensin system in these changes. Moreover it was found that bilateral nephrectomy alone also induced an enhanced zona glomerulosa activity which may be due to a direct effect of changes in potassium homoeostasis.

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